Newest studies

Cardiovascular Risk Reduction in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis

42/100 ✓ Peer-reviewed Prevention and risk Current Cardiology Reports

Key finding: Patients with MASLD are at increased risk for the occurrence of cardiovascular events.

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Association between herpes simplex virus infection and Alzheimer's disease biomarkers: analysis within the MAPT trial

52/100 ✓ Peer-reviewed Tau biomarkers Scientific reports

Key finding: Here, we studied the association between HSV-1 and Alzheimer's disease biomarkers in humans. +3 more findings

• Biomarkers
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Performance and validation of a digital memory test across the Alzheimer's disease continuum

55/100 ✓ Peer-reviewed Cognitive tests and assessment Brain communications

Key finding: Performance of these metrics compared to traditional neuropsychological pen-and-paper screening tests of cognition was also analysed. +2 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Proteins Involved in Endothelial Function and Inflammation Are Implicated in Cerebral Small Vessel Disease

57/100 ✓ Peer-reviewed Vascular contributions Stroke

Key finding: Moreover, 12 proteins related to endothelial function and inflammation were associated with neuroimaging features of SVD. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Neural deterioration and compensation in visual short‐term memory among individuals with amnestic mild cognitive impairment

41/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: Among the atrophic brain regions in aMCI, VSTM performance correlated with the volume of the right prefrontal cortex (PFC) but not the medial temporal lobe (MTL), and this correlation was mainly present in patients with greater MTL atrophy. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Neuropsychiatric symptoms and neuroimaging‐based brain age in mild cognitive impairment and early dementia: A multicenter study

49/100 ✓ Peer-reviewed Digital health tools Psychiatry and Clinical Neurosciences

Key finding: All groups showed significantly increased brain-PAD, and the median (IQR) brain-PAD was 4.3 (5.4) years in MCI, 6.3 (6.2) years in AD, and 5.0 (6.5) years in DLB. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Machine Learning-Based Alzheimer’s Disease Stage Diagnosis Utilizing Blood Gene Expression and Clinical Data: A Comparative Investigation

36/100 ✓ Peer-reviewed Digital health tools Diagnostics

Key finding: Utilizing clinical data, the highest ROC AUC scores attained were 0.989, 0.927, and 0.907 for the identification of the CN, MCI, and dementia stages, respectively. +4 more findings

• Digital Tools
• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

Biomarker Investigation Using Multiple Brain Measures from MRI Through Explainable Artificial Intelligence in Alzheimer’s Disease Classification

43/100 ✓ Peer-reviewed Digital health tools Bioengineering

Key finding: As the leading cause of dementia worldwide, Alzheimer’s Disease (AD) has prompted significant interest in developing Deep Learning (DL) approaches for its classification. +3 more findings

• Digital Tools
• Brain Scans
• Biomarkers

Full summary, score breakdown and related studies → Original source

Estimated pulse wave velocity associated with cognitive phenotypes in a rural older population in China: A cohort study

60/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Per 1-m/s increase in ePWV was associated with an adjusted hazard ratio (HR) (95% confidence interval [CI]) of 1.51(1.30-1.75) for dementia and 1.58(1.33-1.89) for Alzheimer's disease (AD), and with an MMSE score decline (adjusted β-coefficient = -0.36; 95% CI = -0.52 to -0.21). +4 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

Multi‐Targeting Makrozyklische Peptide als Nanomolare Inhibitoren der Selbst‐ und Kreuznukleation der Amyloiden Selbstassemblierung von α‐Synuclein

36/100 ✓ Peer-reviewed Treatments Angewandte Chemie

Key finding: Die amyloide Selbstassemblierung von α‐Synuclein (αSyn) wird mit der Pathogenese der Parkinson‐Krankheit (PD) in Verbindung gebracht. +4 more findings

Full summary, score breakdown and related studies → Original source

Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials

45/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Four hundred eighty-six participants developed dementia during 37,782 person-years of follow-up. +4 more findings

• Genetics
• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Influence of APOE ε4 on performance of CSF biomarkers in differentiating clinical Alzheimer's disease

43/100 ✓ Peer-reviewed Tau biomarkers The journal of prevention of Alzheimer's disease

Key finding: Apolipoprotein E ε4 (APOE ε4) bring the higher risk of Alzheimer' Disease (AD). +3 more findings

• Biomarkers
• Genetics
• Early Stage

Full summary, score breakdown and related studies → Original source

Quantitative Assessment of the Effect of Chronic Kidney Disease on Plasma P-Tau217 Concentrations

69/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: CKD was associated with increased p-tau217 concentrations when measuring p-tau217 by ALZpath and C 2 N methodologies, but the effect was mitigated by the use of %p-tau217. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions

59/100 ✓ Peer-reviewed Genetics Nature communications

Key finding: The integrated Human Microglia Atlas (HuMicA) included 90,716 nuclei/cells and revealed nine populations distributed across all conditions.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Relationships Between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women

55/100 ✓ Peer-reviewed Genetics The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Among all participants (mean age 66.7 ± 6.5 years, 100% non-Hispanic White), 451 (6.6%) were using statins at baseline. +4 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Incidental covert cerebral small vessel disease: Detection and management

39/100 ✓ Peer-reviewed Vascular contributions Advanced Neurology

Key finding: Key debated issues are: (i) the advantages of screening asymptomatic individuals concerning reduced adverse health events or cost-effectiveness, (ii) effective community screening strategies, including the development of non-imaging biomarkers, and (iii) the clinical and therapeutic implications of covert CSVD. +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Elevated Cerebrospinal Fluid α‐Synuclein Seeding Activity Predicts Central Lewy Body Diseases

50/100 ✓ Peer-reviewed Lewy body dementia Movement Disorders Clinical Practice

Key finding: Of 11 subjects with average AUCs above 500,000 units, 7 (64%) developed a central LBD compared to 1 of 20 (5%), with AUCs below the cutoff value (P = 0.0011 by log-rank test). +2 more findings

• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source

Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case–control study

59/100 ✓ Peer-reviewed Risk factors Alzheimer s Research & Therapy

Key finding: We identified a total of 1,686,759 patients with incident dementia (mean (SD) age, 82.15 (6.90) years; 61.70% female) and 3,373,518 matched controls (mean (SD) age, 82.15 (6.90) years; 61.70% female). +4 more findings

• Risk Factors
• Early Stage

Full summary, score breakdown and related studies → Original source

Using consumer wearables to estimate physical activity of nursing home residents with dementia

39/100 ✓ Peer-reviewed Digital health tools Exploration of Digital Health Technologies

Key finding: We showed that consumer wearables are a valid tool for long-term data collection in this vulnerable patient population. +2 more findings

• Digital Tools
• Lifestyle

Full summary, score breakdown and related studies → Original source

Artificial intelligence models using F-wave responses predict amyotrophic lateral sclerosis

50/100 ✓ Peer-reviewed Digital health tools Brain

Key finding: Model scores two standard deviations below the mean had 4 months increased survival (two standard deviations below had 3 months decreased survival). +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Through Their Eyes: Defining ‘good life’ in dementia for health economics and outcomes research

43/100 ✓ Peer-reviewed Disparities Social Science & Medicine

Key finding: Despite progress in involving people living with dementia in health research, disparities remain, particularly in the field of health economics and outcomes research, where excessive reliance on proxy reports from care partners or healthcare professionals persists even when people are capable of self-reporting, leading to inequitable inclusion. +1 more finding

• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT

62/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Of 9,361 randomized participants, 7,221 (77%) were eligible to be re-contacted. +4 more findings

• Risk Factors
• Early Stage
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Inflammatory Potential of the Diet and Risk of Crohn's Disease and Ulcerative Colitis

58/100 ✓ Peer-reviewed Prevention and risk Alimentary Pharmacology & Therapeutics

Key finding: We included 394,255 individuals including 184 incident cases of CD and 459 of UC after median follow-up of 13.6 years (4,889,910 person-years). +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health

51/100 ✓ Peer-reviewed Prevention and risk Clinical Epigenetics

Key finding: Paternal diet and obesity are associated with greater risks of metabolic dysfunction in offspring via epigenetic alterations in the sperm.

• Lifestyle

Full summary, score breakdown and related studies → Original source

Relationship Between Sedentary Lifestyle, Physical Activity and Stress in University Students and Their Life Habits: A Scoping Review with PRISMA Checklist (PRISMA-ScR)

52/100 ✓ Peer-reviewed Prevention and risk Brain Sciences

Key finding: The review analyzed 61 articles and identified a consistent positive correlation between physical activity and stress reduction. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source