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Elevated Cerebrospinal Fluid α‐Synuclein Seeding Activity Predicts Central Lewy Body Diseases
David S. Goldstein, Parvez Alam, Patti Sullivan, Courtney S. Holmes, Janna Gelsomino, Andrew G. Hughson, Byron Caughey. Movement Disorders Clinical Practice, 2025-01-16
Topic: Brain proteins, microglia and lab models
Of 11 subjects with average AUCs above 500,000 units, 7 (64%) developed a central LBD compared to 1 of 20 (5%), with AUCs below the cutoff value (P = 0.0011 by log-rank test). Conversely, 7 of 8 (88%) LBD+ participants had elevated initial AUCs. Increased CSF SSA predicts central LBDs. Individuals who develop a central LBD have elevated initial SSA AUCs.
Key findings
- Of 11 subjects with average AUCs above 500,000 units, 7 (64%) developed a central LBD compared to 1 of 20 (5%), with AUCs below the cutoff value (P = 0.0011 by log-rank test).
- Conversely, 7 of 8 (88%) LBD+ participants had elevated initial AUCs.
- Individuals who develop a central LBD have elevated initial SSA AUCs.
Why it matters
This longitudinal study found that elevated cerebrospinal fluid alpha-synuclein seeding activity predicts central Lewy body diseases, with 64% of those above a cutoff developing LBD compared to 5% below. It supports a predictive biomarker but does not provide a treatment or cure.
Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 50/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 48 of the 96 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Movement Disorders Clinical Practice) |
| Journal's citation record | 0 / 4 | Movement Disorders Clinical Practice: journal h-index 59 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 9 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Byron Caughey holds only 9 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 3 / 3 | National Institutes of Health: institution h-index 2,723 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39817492) |
| Free to read | 2 / 2 | Free to read |
| Points | 48 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 48 of the 96 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Goldstein, D. S., Alam, P., Sullivan, P., Holmes, C. S., Gelsomino, J., Hughson, A. G., et al. (2025). Elevated Cerebrospinal Fluid α‐Synuclein Seeding Activity Predicts Central Lewy Body Diseases. Movement Disorders Clinical Practice. https://doi.org/10.1002/mdc3.14333
Vancouver
Goldstein DS, Alam P, Sullivan P, Holmes CS, Gelsomino J, Hughson AG, et al. Elevated Cerebrospinal Fluid α‐Synuclein Seeding Activity Predicts Central Lewy Body Diseases. Movement Disorders Clinical Practice. 2025. doi:10.1002/mdc3.14333. PMID: 39817492.
BibTeX
@article{goldstein2025-39817492,
author = {Goldstein, David S. and Alam, Parvez and Sullivan, Patti and Holmes, Courtney S. and Gelsomino, Janna and Hughson, Andrew G. and Caughey, Byron},
title = {{Elevated Cerebrospinal Fluid α‐Synuclein Seeding Activity Predicts Central Lewy Body Diseases}},
journal = {Movement Disorders Clinical Practice},
year = {2025},
doi = {10.1002/mdc3.14333},
pmid = {39817492},
url = {https://doi.org/10.1002/mdc3.14333}
}
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