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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 26–50 of 27,380 studies, newest first · page 2 of 1096.

October 2026 25

  1. 2026-10-29

    Joint localization and testing reveals spatial context of differential expression

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Together, these results show that the spatial context of differential expression can be inferred jointly with gene-level associations, recovering signals obscured by regional aggregation without requiring the relevant tissue context to be defined in advance.

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  2. 2026-10-29

    The TREM-receptor family interactome in the human brain

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Here, we used human AD and non-AD brain lysate to profile the interactome of the ligand binding domains of the different TREM receptors. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  3. 2026-10-29

    A digital programme to prevent falls and improve wellbeing in people living with dementia in the community: Quantitative results from the KOKU-LITE feasibility study

    ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment medRxiv

    Key finding: Sixty participants (30 intervention, 30 control) were recruited and followed up between March 2024 to September 2025. +4 more findings

    Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2026-10-29

    SHED-Derived Exosomes Attenuate Alzheimer's Disease Pathology in iPSC-Derived Cerebral Organoid Model

    ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

    Key finding: SHED exosome treatment demonstrated genotype-specific efficacy, selectively reducing p181-tau levels and restoring the p181-tau/Aβ42 ratio in FAD lines while elevating the protective Aβ42/Aβ40 ratio across both FAD and SAD backgrounds. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-10-29

    Blood-based biomarkers across the Alzheimer's disease continuum in older Korean population

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: Plasma pTau217 best identified amyloid-PET positivity (AUC > 0.91). +4 more findings

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  6. 2026-10-28

    The Contribution of Routinely Collected Clinical Data to Dementia Identification in Primary Care: A Cross-Sectional Study

    ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Research Square

    Key finding: Sociodemographic and clinical variables routinely recorded in PC EHRs may contribute to dementia identification. +2 more findings

    Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  7. 2026-10-28

    Neuronal Hyperactivity Induces Tau Phosphorylation Selectively in Excitatory Pyramidal Neurons Which Contributes to GluA2 Regulation

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: Extending these findings to mice, chronic low-dose picrotoxin treatment increased endogenous S202/T205 tau phosphorylation in CA3 neurons. +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  8. 2026-10-28

    A Binding Site for CVN293 Reveals a Mechanism for Allosteric Control of THIK-1 K2P Channel Gating

    ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system bioRxiv

    Key finding: Overall, our results provide important structural insights into the regulation of THIK-1 activity and define an inhibitory mechanism for CVN293, a potentially important therapeutic modulator of microglial function.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  9. 2026-10-28

    Neuroscience-Informed Psychoeducation for Dementia: From Network Degeneration to Compassionate and Skilled Care

    ⚠ Preprint — not yet peer-reviewed Risk factors PsyArXiv

    Key finding: Dementia is a progressive syndrome characterized by neurodegeneration across distributed brain networks that results in cognitive, behavioral, and functional declines.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  10. 2026-10-28

    Geographic Heterogeneity in the Association Between Schooling and Cognitive Change Among Older Adults in India

    ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

    Key finding: Higher educational attainment is associated with steeper measured cognitive decline among older adults in India, but whether this association is uniform across the country is unknown. +1 more finding

    Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  11. 2026-10-28

    Beyond Glycemic Control: The Pleiotropic Role of GLP-1RAs and Melatonin in Combating Neuroinflammation and Mitochondrial Dysfunction

    ⚠ Preprint — not yet peer-reviewed Drug development Preprints.org

    Key finding: This narrative review examines the pharmacological diversity and central nervous system accessibility of GLP-1RAs, including emerging multi-receptor agonists, and their convergence with melatonin on AMPK, sirtuin–PGC-1α, and mitochondrial quality-control networks. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  12. 2026-10-28

    From group-level neurophysiological biomarkers to individual-level phenotyping to identify mechanisms of neurodegenerative disease

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

    Key finding: Clinical scores showed strong individual-level translation, consistent with clinical diagnostic definitions (e.g, controls-vs-PSP accuracy 0.94; bvFTD-vs-PSP accuracy 0.83). +4 more findings

    Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-10-28

    Soluble TREM2 suppresses neuronal activity

    ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics Research Square

    Key finding: These findings establish a physiological role of sTREM2 as a fast-acting modulator of neuronal activity.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2026-10-28

    Single-Nucleus Profiling Reveals Neuronal Metabolic Collapse During the Transition to Alzheimer’s Disease Dementia

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Here, we addressed this discrepancy by investigating the molecular mechanisms underlying AD dementia using single-nucleus RNA-sequencing and single-nucleus multiome datasets. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  15. 2026-10-28

    Neuropsychiatric symptom clusters and plasma proteomic signatures across cognitive ageing and dementia in Kinshasa, Democratic Republic of the Congo: a cross-sectional analysis of the EVCD-RDC cohort

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

    Key finding: The full cohort included 1044 participants, of whom 779 comprised the proteomics cohort. +4 more findings

    Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  16. 2026-10-28

    Factors Influencing the Implementation of Computerized Cognitive Training in Chinese Community-Dwelling Elderly: A Qualitative Study

    ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square

    Key finding: Four main themes were extracted: (1) Positive experiences, including perceived improvement in cognitive function and mood; (2) Facilitators and barriers to training participation, with facilitators comprising dementia care experience, higher educational attainment, and availability of free time, and barriers including unfamiliarity with computer operation, low awareness of cognitive training, and lengthy training sessions; (3) Training content preferences, reflecting a desire for both relaxed, engaging content and professional guidance; and (4) Practical dilemmas and suggestions, including difficulties in understanding task instructions and complex login procedures, with recommendations for detailed task descriptions and simplified procedures. +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-10-28

    CSF Alzheimer’s Disease Biomarkers in Relation to Functional Status and Tofersen Treatment Response in ALS

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

    Key finding: Emerging evidence suggests that AD-related pathological changes and AD-related biomarkers may appear in ALS, yet their diagnostic and prognostic significance remains unclear. +3 more findings

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2026-10-28

    Brain-Derived pTau217 and Plasma Proteomic Profiles Across Cognitive and Dementia Groups in Congolese Older Adults

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: Sex showed the strongest associations with protein expression, followed by age, whereas APOE ε4 carrier status was associated with four measures. +3 more findings

    Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  19. 2026-10-28

    Detection of tau spatial extent using MK6240 and flortaucipir PET

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: TSE showed stronger unadjusted associations than SUVR in selected region- and outcome-specific comparisons, supporting its potential as a complementary measure. +1 more finding

    Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  20. 2026-10-28

    Cognition in healthy aging, ages 36 to 108: Associations with dementia risk factors and neurodegenerative disease biomarkers

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: Five modifiable factors were associated with performance: education, diabetes, low motor function, hearing loss and low vision (all FDR q < 0.05). +3 more findings

    Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2026-10-27

    Repeated VU0155069 Treatment Is Associated with Region- and Pathological Stage-Specific Dendritic Spine Remodeling in Female 3xTg-AD Mice

    ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology bioRxiv

    Key finding: VU0155069 engages circuit- and pathological stage-specific forms of dendritic spine remodeling across distributed recognition- and associative-memory networks. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-10-27

    High-content imaging of live microglia-containing Alzheimer’s disease brain organoids

    ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system bioRxiv

    Key finding: This method establishes a platform for high-throughput longitudinal drug screening in immunocompetent human COs that will enable the identification of new therapeutic candidates to modulate Aβ aggregation, glial reactivity, and neurodegeneration. +4 more findings

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  23. 2026-10-27

    Second-generation tau PET tracer in situ binding assessed with fluorescence imaging

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

    Key finding: The results show that GTP1 binds to tau tangles and neuropil threads (NPTs), but not amyloid-β plaques. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  24. 2026-10-27

    CEP-IP with CMRF in SEA-AD Microglia: A Mitochondrial Co-expression Module Linked to Cognition

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: The donor percentage of Module cells past the IP (Module post-IP%) was significantly associated with worse cognition (MMSE and CASI; FDR<0.05) in all three populations. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2026-10-27

    Ms4a4a loss preferentially remodels microglia with limited, compartment-specific effects across central and peripheral immune compartments in 5xFAD mice

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: These findings identify microglia as the immune population most strongly remodeled by Ms4a4a loss in the setting of amyloid pathology. +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →