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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,751–11,775 of 27,380 studies, newest first · page 471 of 1096.

April 2020 25

  1. 2020-04-06

    Recent advances in understanding the role of glucagon-like peptide 1

    ✓ Peer-reviewed Drug development F1000Research

    Key finding: The discovery that glucagon-like peptide 1 (GLP-1) mediates a significant proportion of the incretin effect during the postprandial period and the subsequent observation that GLP-1 bioactivity is retained in type 2 diabetes (T2D) led to new therapeutic strategies being developed for T2D treatment based on GLP-1 action.

    Full summary, score breakdown and related studies → Original source

  2. 2020-04-05

    A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain

    ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry

    Key finding: It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in considerable part from synaptic dysfunction caused by the accumulation of a range of oligomeric assemblies of amyloid β-protein (Aβ). +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-04-03

    Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis

    ✓ Peer-reviewed Long-term cohort studies Science bulletin

    Key finding: However, whether hippocampal radiomic features are robust as predictors of progression from mild cognitive impairment (MCI) to AD dementia and whether these features provide any neurobiological foundation remains unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2020-04-03

    Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease

    ✓ Peer-reviewed Caregiving Nature communications

    Key finding: Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [ 18 F]flortaucipir uptake. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-04-03

    Sex and gender differences in Alzheimer's disease: current challenges and implications for clinical practice: Position paper of the Dementia and Cognitive Disorders Panel of the European Academy of Neurology

    ✓ Peer-reviewed Prevention and risk European journal of neurology

    Key finding: Evidence exists on sex and gender differences in the rate of cognitive deterioration and brain atrophy, and in the effect of risk factors as well as in the patterns of diagnostic biomarkers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-04-02

    Alzheimer's disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?

    ✓ Peer-reviewed Risk factors Biochemical pharmacology

    Key finding: Together with numerous reports that amyloid is present in brains from aged individuals without cognitive dysfunction, this suggests that the association of amyloid with AD is collateral rather than causal. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-04-02

    Early Diagnosis of Alzheimer's Disease in Blood Using a Disposable Electrochemical Microfluidic Platform

    ✓ Peer-reviewed Biomarkers ACS sensors

    Key finding: The diagnosis of AD in early stage can significantly improve the evolution and prognosis of the disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2020-04-02

    A narrative review of facilitating and inhibiting factors in advance care planning initiation in people with dementia

    ✓ Peer-reviewed End-of-life care European geriatric medicine

    Key finding: This review highlighted the main challenges associated with optimal ACP initiation with PwD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2020-04-02

    Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence

    ✓ Peer-reviewed Prevention trials Communications biology

    Key finding: In particular, alterations in aging neural stem cells (NSCs) are linked to age-related cognitive decline which can be modulated by lifestyle. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2020-04-02

    Evaluating the Feasibility of Frequent Cognitive Assessment Using the Mezurio Smartphone App: Observational and Interview Study in Adults With Elevated Dementia Risk

    ✓ Peer-reviewed Digital health tools JMIR mHealth and uHealth

    Key finding: Despite the extended study duration, participants demonstrated high compliance with the schedule of daily learning tasks and were extremely positive about their experiences. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2020-04-02

    Research criteria for the diagnosis of prodromal dementia with Lewy bodies

    ✓ Peer-reviewed Getting a diagnosis Neurology

    Key finding: The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-04-01

    Piperine: A comprehensive review of methods of isolation, purification, and biological properties

    ✓ Peer-reviewed Risk factors Medicine in Drug Discovery

    Key finding: Different studies on piperine suggest that piperine acts as an excellent bioenhancer to improve the bioavailability of drugs with poor ADMET properties. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2020-04-01

    Network localization of clinical, cognitive, and neuropsychiatric symptoms in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

    Key finding: Prior work has shown that both group-level atrophy in clinical dementia syndromes and complex neurological symptoms in patients with focal brain lesions localize to brain networks. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2020-04-01

    Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages

    ✓ Peer-reviewed TREM2 and immune genetics FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Key finding: LC-MS/MS analysis of recombinant TREM2 incubated with meprin β revealed predominant cleavage between Arg136 and Asp137, distant to the site identified for ADAM10/17. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2020-04-01

    Analytical and Clinical Performance of Amyloid-Beta Peptides Measurements in CSF of ADNIGO/2 Participants by an LC-MS/MS Reference Method

    ✓ Peer-reviewed Biomarkers Clinical chemistry

    Key finding: CRM-adjusted Aβ42 calibrator concentrations were calculated using the regression equation Y (CRM-adjusted) = 0.89X (calibrators) + 32.6. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2020-04-01

    The blood-brain barrier in health and disease: Important unanswered questions

    ✓ Peer-reviewed Vascular contributions The Journal of experimental medicine

    Key finding: The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control the movement of ions, molecules, and cells between the blood and the parenchyma. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2020-04-01

    Development and Validation of a Prognostic Survival Model With Patient-Reported Outcomes for Patients With Cancer

    ✓ Peer-reviewed End-of-life care JAMA network open

    Key finding: After backward stepwise selection in year 0, the following factors were associated with increased risk of death by more than 10%: being hospitalized; having congestive heart failure, chronic obstructive pulmonary disease, or dementia; having moderate to high pain; having worse well-being; having functional status in the transitional or end-of-life phase; having any problems with appetite; receiving end-of-life home care; and living in a nursing home. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2020-04-01

    Long-Term Trajectories of Body Weight, Diet, and Physical Activity From Midlife Through Late Life and Subsequent Cognitive Decline in Women

    ✓ Peer-reviewed Prevention trials American journal of epidemiology

    Key finding: From midlife through later life, compared with controls, cases had consistently lower A-MeDi scores but a deceleration of weight gain and a faster decrease in physical activity. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2020-04-01

    South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial

    ✓ Peer-reviewed Prevention trials Journal of clinical neurology (Seoul, Korea)

    Key finding: The results obtained will provide information on the applicability of these multidomain intervention programs to at-risk elderly people.

    Full summary, score breakdown and related studies → Original source

  20. 2020-04-01

    Serious video games and virtual reality for prevention and neurorehabilitation of cognitive decline because of aging and neurodegeneration

    ✓ Peer-reviewed Prevention trials Current opinion in neurology

    Key finding: Cognitive decline because of aging and neurodegeneration has become increasingly prevalent.

    Full summary, score breakdown and related studies → Original source

  21. 2020-04-01

    Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

    ✓ Peer-reviewed Inflammation and the immune system The Journal of clinical investigation

    Key finding: Previously, we demonstrated a potent IFN immunogenicity of nucleic acid-containing (NA-containing) amyloid fibrils in the periphery. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2020-04-01

    Prediction of dementia risk in low-income and middle-income countries (the 10/66 Study): an independent external validation of existing models

    ✓ Peer-reviewed Long-term cohort studies The Lancet. Global health

    Key finding: However, most people with dementia live in low-income and middle-income countries (LMICs), where dementia risk prediction research is almost non-existent and the ability of current models to predict dementia is unknown. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2020-04-01

    Characterization of Alzheimer Disease Biomarker Discrepancies Using Cerebrospinal Fluid Phosphorylated Tau and AV1451 Positron Emission Tomography

    ✓ Peer-reviewed Long-term cohort studies JAMA neurology

    Key finding: Fluid and imaging biomarkers of Alzheimer disease (AD) are often used interchangeably, but some biomarkers may reveal earlier stages of disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-04-01

    Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

    Key finding: We found that amyloid-β-positive cognitively unimpaired individuals were mainly characterized by decreased functional connectivity between the medial temporal lobe and regions in the anterior-temporal system, most prominently between left perirhinal/entorhinal cortices and medial prefrontal cortex. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2020-04-01

    LRP1 is a master regulator of tau uptake and spread

    ✓ Peer-reviewed Lewy body dementia Nature

    Key finding: This observation and complementary experimental studies 3,4 have suggested that tau can spread in a prion-like manner, by passing to naive cells in which it templates misfolding and aggregation. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →