Newest studies

Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment

16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square

Key finding: Among 10,489 participants with incident MCI, the mean age at the incident MCI wave was 70.6 years (SD = 11.53), and 56.6% were female. +4 more findings

• Early Stage

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Inflammatory biomarker candidates in dementia with Lewy bodies: diagnostic classification, clinical associations, and survival

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology Research Square

Key finding: Because alpha-synuclein pathology is associated with central and peripheral immune alterations, targeted measurement of inflammation-related biomarker candidates may provide a minimally invasive means of characterizing disease biology and supporting differential diagnosis. +3 more findings

• Other Dementias
• Brain Biology
• Diagnosis

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Molecular MRI of Neuroinflammation in Alzheimer's Disease using a Folate-targeted Nanoprobe

16/100 ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system bioRxiv

Key finding: Microglial activation and FR expression in APP/PS1 and P301S transgenic mouse models of AD was measured using flow cytometry. +4 more findings

• Brain Biology
• Brain Scans

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Large-scale head-to-head comparison of on- and off-target profiles of [18F]Tauvid and [18F]MK6240 tau-PET in aging and Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

Key finding: [ 18 F]Tauvid and [ 18 F]MK6240 capture largely overlapping patterns of tau pathology, but differ notably in the magnitude of off-target binding. +2 more findings

• Brain Scans
• Brain Biology

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Longitudinal plasma biomarkers and multimodal PET across APOE ε4 genotypes: a prospective cohort study

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

Key finding: These findings support a model in which p-tau217 specifically tracks amyloid-driven pathological progression, while markers of neurodegeneration reflect broader age-related processes that are not associated with APOE genotype. +2 more findings

• Biomarkers
• Genetics
• Brain Scans

Scored 42 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Repetitive negative thinking is associated with amyloid accumulation over 3 years in cognitively healthy adults

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

Key finding: RNT was associated with increasing global amyloid accumulation even after controlling for psychological symptoms (B = 0.0120, 95% Confidence Interval 0.003 to 0.021, P = 0.012), and in sensitivity analyses limited to participants aged ≥50 or ≥60. +4 more findings

• Brain Scans

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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APH-1A and CDK5 Expression Correlates with Tau Hyperphosphorylation and Its Attenuation by Brahmi and Donep-M in STZ induced Alzheimer’s Disease Model

16/100 ⚠ Preprint — not yet peer-reviewed Genetics Research Square

Key finding: Here, we employed an integrated transcriptomic and cellular approach to identify and validate biomarkers associated with AD pathology. +3 more findings

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Neuroinflammation is an early pathological process in a mouse model of prodromal Parkinsons disease

16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment bioRxiv

Key finding: Stereological quantification revealed no significant neuronal loss in the AON or PCX during this 1–3 month interval, indicating that olfactory impairment precedes overt neurodegeneration. +2 more findings

• Brain Biology
• Early Stage
• Other Dementias

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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TMEM106B C-Terminal fragment aggregation exacerbates α-synuclein and TDP-43 proteinopathy phenotypes

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology bioRxiv

Key finding: We demonstrated that TMEM CT neuronal aggregation drives severe neuronal dysfunction and neuronal loss. +2 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Opposing Regulation of Tau Condensation by Phosphorylation Levels and Molecular Chaperone Interactions

16/100 ⚠ Preprint — not yet peer-reviewed Treatments bioRxiv

Key finding: We found that the phosphorylation pattern modulates Tau fibrillation and enhances its droplet-formation propensity. +2 more findings

• Treatments
• Policy

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Tau-CTFP: A connectome-informed continuous-time first-passage model for forecasting the onset of regional tau PET abnormality

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: Tau PET burden is associated with subsequent cognitive decline in Alzheimer's disease, motivating forecasts for monitoring and studies of spatially targeted therapies. +2 more findings

• Brain Scans

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Integrative systems biology identifies shared neuroimmune co-expression programmes across pulmonary tuberculosis and Alzheimer's disease

16/100 ⚠ Preprint — not yet peer-reviewed Genetics Research Square

Key finding: Active PTB was associated with widespread transcriptional remodeling, with 1,389 dysregulated genes organized into 16 PTB-associated co-expression modules. +4 more findings

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Disrupting SORL1-retromer endosomal recycling in mice drives the age-dependent neurodegenerative signature of Alzheimer's disease

16/100 ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

Key finding: MRI studies revealed that SORL1 deficiency induced an age-dependent AD-pattern of atrophy, centered on the trans-entorhinal cortex, and that atrophy was prevented by SORL1 restoration, secondary to overexpressing the retromer protein VPS26b. +2 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Pregnancy History and Loss of Normal PSEN2 Function Impact Female Late-Life Cognitive Processing, Inhibitory Signaling, and Gliosis

16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv

Key finding: This work suggests that although parity history and PSEN2 deficiency exert individual differing age-related effects on cognition and neurobiology, they do not act synergistically.

• Genetics
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures

16/100 ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

Key finding: The rs28834970 regulatory variant was identified as the most functionally relevant in our model, with the C risk allele promoting transcription factor C/EBPβ binding within a cis-regulatory element. +4 more findings

• Genetics
• Brain Biology
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Concurrent cognitive, behavioral and systemic physiological features mark preclinical Alzheimer's disease

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv

Key finding: Reported modifiable risk factor histories were not associated with p-tau217 when effectively managed. +1 more finding

• Biomarkers
• Early Stage

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The metabolic-brain axis: GLP-1 signaling, insulin resistance, and obesity pharmacotherapy in neurodegeneration

45/100 ✓ Peer-reviewed Drug development Metabolism: clinical and experimental

Key finding: Converging epidemiological, mechanistic, and pharmacological evidence supports a bidirectional metabolic-brain axis in which systemic insulin resistance, obesity, and chronic metabolic inflammation are associated with and may contribute to alterations in neuronal survival, synaptic plasticity, and neuroimmune homeostasis. +2 more findings

• Clinical Trials
• Treatments
• Brain Biology

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Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: However, we reported greater vascular Aβ deposition in APPdup than in DS with AD, suggesting that other triplicated chromosome 21 genes may mitigate CAA severity. +2 more findings

• Down Syndrome
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Elder Caregiving in Southeast Asia: A Systematic Review of Cultural Norms, Care Burdens, Carer Support and Policy Gaps

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving Research Square

Key finding: Forty-eight studies from ten Southeast Asian countries were reviewed. +4 more findings

• Caregiving
• Policy

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Aβ42 oligomers disrupt calcium homeostasis via Piezo1 and induce neurotoxicity in differentiated SH-SY5Y cells

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research Square

Key finding: Aβ42 oligomer adsorption increases cellular Young's modulus, which is associated with sustained intracellular Ca 2+ elevation mediated by Piezo1. +1 more finding

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol

69/100 ✓ Peer-reviewed Clinical trials NIHR Open Res

Key finding: The PROMPPT trial will assess whether review by trained clinical pharmacists working in general practices can support safe opioid reduction without compromising pain management and quality of life. +1 more finding

• Clinical Trials
• Care Services
• Policy

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Effect of Metformin on tau pathology and proteostasis in cellular and a Drosophila model of Tauopathy

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: This dissociation was associated with enhanced activation of AKT and AMPK signalling and maintenance of basal phosphatase activity. +1 more finding

• Treatments
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Endocannabinnoids innervate Circadian mechinary mitigating neuroinflammation, amyloidogenesis and cognition phenotypic to AD

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Authorea Preprints

Key finding: Constant LL exposure induced complete arrhythmicity and impaired recognition, working, and spatial reference memory. +4 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Wasserstein Weisfeiler-Lehman Kernel Framework for Multimodal Brain Connectome Analysis

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

Key finding: Under nested cross-validation, the WWL kernel achieves a balanced accuracy of $0.651\pm0.028$, significantly outperforming both a raw-feature SVM and a histogram-based WL-kernel baseline. +2 more findings

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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PIN1-p53 bifurcation dictates opposite cell fate decisions in Alzheimer’s disease and glioblastoma via distinct energy landscape topologies

16/100 ⚠ Preprint — not yet peer-reviewed Genetics Research Square

Key finding: Although Alzheimer’s disease (AD) and glioblastoma (GBM) share common aging-related risk factors, they lead to opposite cellular fates—neurodegeneration versus uncontrolled proliferation. +1 more finding

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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