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49/100

✓ Peer-reviewed alzhub usefulness score 49 out of 100. Digital health tools

Topic: Risk, prevention and care in population studies

All groups showed significantly increased brain-PAD, and the median (IQR) brain-PAD was 4.3 (5.4) years in MCI, 6.3 (6.2) years in AD, and 5.0 (6.5) years in DLB. The NPI scores were subdivided into the following four categories: (i) Agitation and Irritability, (ii) Depression and Apathy, (iii) Delusions and Hallucinations, and (iv) Euphoria and Disinhibition. We found a significantly positive correlation between brain-PAD and the depression/apathy factor (Spearman's rs = 0.156, FDR-corrected P = 0.002), whereas no significance was shown for the other NPS factors. Higher brain-age may be associated with depression and apathy symptoms presented in MCI to early dementia stages, and brain-age analysis may be useful as a novel biomarker for the assessment or monitoring of NPS.

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APA 7th

Sone, D., Beheshti, I., Tagai, K., Kameyama, H., Takasaki, E., Kashibayashi, T., et al. (2025). Neuropsychiatric symptoms and neuroimaging‐based brain age in mild cognitive impairment and early dementia: A multicenter study. Psychiatry and Clinical Neurosciences. https://doi.org/10.1111/pcn.13777

Vancouver

Sone D, Beheshti I, Tagai K, Kameyama H, Takasaki E, Kashibayashi T, et al. Neuropsychiatric symptoms and neuroimaging‐based brain age in mild cognitive impairment and early dementia: A multicenter study. Psychiatry and Clinical Neurosciences. 2025. doi:10.1111/pcn.13777. PMID: 39821434.

BibTeX

@article{sone2025-39821434,
  author  = {Sone, Daichi and Beheshti, Iman and Tagai, Kenji and Kameyama, Hiroshi and Takasaki, Emi and Kashibayashi, Tetsuo and Takahashi, Ryuichi and Ishii, Kazunari and others},
  title   = {{Neuropsychiatric symptoms and neuroimaging‐based brain age in mild cognitive impairment and early dementia: A multicenter study}},
  journal = {Psychiatry and Clinical Neurosciences},
  year    = {2025},
  doi     = {10.1111/pcn.13777},
  pmid    = {39821434},
  url     = {https://doi.org/10.1111/pcn.13777}
}

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Key findings

All groups showed significantly increased brain-PAD, and the median (IQR) brain-PAD was 4.3 (5.4) years in MCI, 6.3 (6.2) years in AD, and 5.0 (6.5) years in DLB.
The NPI scores were subdivided into the following four categories: (i) Agitation and Irritability, (ii) Depression and Apathy, (iii) Delusions and Hallucinations, and (iv) Euphoria and Disinhibition.
We found a significantly positive correlation between brain-PAD and the depression/apathy factor (Spearman's rs = 0.156, FDR-corrected P = 0.002), whereas no significance was shown for the other NPS factors.
Higher brain-age may be associated with depression and apathy symptoms presented in MCI to early dementia stages, and brain-age analysis may be useful as a novel biomarker for the assessment or monitoring of NPS.

Why it matters

In this cross-sectional multicenter study, brain age was higher than chronological age in people with mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies, and higher brain age was associated with depression and apathy symptoms. Brain-age analysis may be useful as a biomarker for assessing neuropsychiatric symptoms, but this does not treat, cure, or prevent Alzheimer's disease.

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Study details

Study designcross-sectional
Participants185
Evidence strengthLow

How this study scored 49/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Psychiatry and Clinical Neurosciences)
Journal's citation record	1 / 4	Psychiatry and Clinical Neurosciences: journal h-index 120 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	185 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 9 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.0 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 5.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Hiroaki Kazui: h-index 49 (OpenAlex, whole career)
Institution's track record	1 / 3	The University of Osaka: institution h-index 1,138 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 8 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39821434)
Free to read	2 / 2	Free to read
Total	49 / 100	—

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