Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials
Nicola Coley, Marieke P. Hoevenaar‐Blom, Jason Shourick, Eric P. Moll van Charante, Jan Willem van Dalen, Willem A. van Gool, Edo Richard, Sandrine Andrieu et al.. Alzheimer s & Dementia, 2025-01-17
Topic: Risk, prevention and care in population studies
Plain-language summary
Four hundred eighty-six participants developed dementia during 37,782 person-years of follow-up. Higher incidence was associated with baseline age, APOE ε4 genotype, physical inactivity, Mini-Mental State Examination, and blood pressure. Multidomain intervention had no effect on incident dementia overall (hazard ratio = 0.98, 95% confidence interval 0.80-1.21), or in any pre-specified subgroup. A recursive partitioning algorithm also did not detect any subgroups, defined by single or multiple risk factors, showing a differential intervention effect. We did not identify any subgroups of older adults in whom multidomain interventions significantly reduced incident dementia. CLINICAL TRIAL REGISTRATION: MAPT: NCT00672685 (clinicaltrials.gov); PreDIVA: ISRCTN29711771 (ISRCTN registry) HIGHLIGHTS: We pooled up to 12 years of follow-up data from two multidomain prevention trials. Five thousand two hundred five participants aged ≥ 70 were included. Subgroups were pre-defined by modifiable and non-modifiable dementia risk factors. A data-driven recursive partitioning algorithm was also used. Multidomain intervention did not lower incident dementia overall or in any subgroup.
What this study adds
Evidence grade: Low
The record lists 5,205 participants. In this pooled analysis of two large prevention trials, multidomain intervention did not reduce the incidence of dementia overall or in any subgroup examined. This means that, based on these data, multidomain lifestyle interventions did not prevent dementia in older adults.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Coley, N., Hoevenaar‐Blom, M. P., Shourick, J., van Charante, E. P. M., van Dalen, J. W., van Gool, W. A., et al. (2025). Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials. Alzheimer s & Dementia. https://doi.org/10.1002/alz.14472
Vancouver
Coley N, Hoevenaar‐Blom MP, Shourick J, van Charante EPM, van Dalen JW, van Gool WA, et al. Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials. Alzheimer s & Dementia. 2025. doi:10.1002/alz.14472. PMID: 39821948.
BibTeX
@article{coley2025-39821948,
author = {Coley, Nicola and Hoevenaar‐Blom, Marieke P. and Shourick, Jason and van Charante, Eric P. Moll and van Dalen, Jan Willem and van Gool, Willem A. and Richard, Edo and Andrieu, Sandrine and others},
title = {{Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.14472},
pmid = {39821948},
url = {https://doi.org/10.1002/alz.14472}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Four hundred eighty-six participants developed dementia during 37,782 person-years of follow-up.
- Higher incidence was associated with baseline age, APOE ε4 genotype, physical inactivity, Mini-Mental State Examination, and blood pressure.
- Multidomain intervention had no effect on incident dementia overall (hazard ratio = 0.98, 95% confidence interval 0.80-1.21), or in any pre-specified subgroup.
- A recursive partitioning algorithm also did not detect any subgroups, defined by single or multiple risk factors, showing a differential intervention effect.
- We did not identify any subgroups of older adults in whom multidomain interventions significantly reduced incident dementia.
Why it matters
In this pooled analysis of two large prevention trials, multidomain intervention did not reduce the incidence of dementia overall or in any subgroup examined. This means that, based on these data, multidomain lifestyle interventions did not prevent dementia in older adults.
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Study details
- Participants5,205
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 43 of the 96 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 5,205 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 12 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39821948) |
| Free to read | 2 / 2 | Free to read |
| Points | 43 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 43 of the 96 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
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