Newest studies

Salmonellosis in Cattle: Sources and Risk of Infection, Control, and Prevention

39/100 ✓ Peer-reviewed Prevention and risk Zoonotic Diseases

Key finding: We conclude that a holistic approach involving all stakeholders in cattle production is needed to safeguard public health, eventually forestalling human salmonellosis from cattle sources.

• Prevention

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Prophylactic effects of nutrition, dietary strategies, exercise, lifestyle and environment on nonalcoholic fatty liver disease

42/100 ✓ Peer-reviewed Prevention and risk Annals of Medicine

Key finding: Reasonable nutrient intake encompassing macronutrients and micronutrients have an independent protective relationship with NAFLD. +4 more findings

• Lifestyle
• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Analytical Review on Nutritional Deficiencies in Vegan Diets: Risks, Prevention, and Optimal Strategies

35/100 ✓ Peer-reviewed Prevention and risk Journal of the American Nutrition Association

Key finding: While studies confirm that veganism reduces the risk of chronic diseases, such as diabetes, obesity, and heart disease, significant challenges persist in meeting nutritional needs. +3 more findings

• Lifestyle
• Prevention

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Colorectal Cancer: Epidemiology, Risk Factors, and Public Health Strategies

49/100 ✓ Peer-reviewed Prevention and risk Digestion

Key finding: Enhancing CRC screening, early detection, and public health interventions can significantly reduce CRC-related mortality. +2 more findings

• Risk Factors
• Prevention
• Lifestyle

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L-Lactate Administration Improved Synaptic Plasticity and Cognition in Early 3xTg-AD Mice

43/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

Key finding: Our findings reveal significant reductions in hippocampal lactate levels in experimental AD mice. +3 more findings

• Brain Biology

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Development of Neurodegenerative Disease Diagnosis and Monitoring from Traditional to Digital Biomarkers

43/100 ✓ Peer-reviewed Cognitive tests and assessment Biosensors

Key finding: Monitoring and assessing the progression of symptoms in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are critical for improving patient outcomes. +4 more findings

• Diagnosis
• Digital Tools
• Biomarkers

Full summary, score breakdown and related studies → Original source

White matter hyperintensity severity modifies gut metabolite association with cognitive outcomes

55/100 ✓ Peer-reviewed Vascular contributions The Journal of Prevention of Alzheimer s Disease

Key finding: Of 104 metabolites studied, glycodeoxycholic acid (GDCA) surpassed the false discovery rate and was associated the Alzheimer's Disease Assessment Scale-Cognitive Subscale version 13 (ADAS-Cog13) score (β = 0.12, 95 % CI = 0.05-0.20, p = 0.001) and cognitive impairment determined by mini-mental status exam (MMSE) (OR = 2.11, 95 % CI = 1.41-3.15, p < 0.001). +3 more findings

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Proteolytic therapeutic modalities for amyloidoses: Insights into immunotherapy, PROTAC, and photo-oxygenation

41/100 ✓ Peer-reviewed Disease mechanisms Neurotherapeutics

Key finding: PROTAC is a small molecule that uses the ubiquitin-proteasome system to degrade intracellular target proteins and has demonstrated efficacy in clinical trials for other diseases. +1 more finding

• Treatments

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The Prevention of Fatal Tauopathy in a Mouse Model of Alzheimer Disease by Blocking BCL2

36/100 ✓ Peer-reviewed Inflammation and the immune system Applied immunohistochemistry & molecular morphology

Key finding: The treated mice were robust until sacrificed at 13 months as compared with the untreated mice that showed unequivocal evidence of brain and spinal cord damage both clinically and at autopsy. +1 more finding

• Brain Biology
• Treatments
• Prevention

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Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease

39/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroimmune Pharmacology

Key finding: It primarily affects cerebral regions responsible for cognition, memory, and language processing, significantly impeding the functional independence of patients.

• Brain Biology

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Comorbidity Trajectories Before and After the Diagnosis of Heart Failure: A UK Biobank Cohort Study

51/100 ✓ Peer-reviewed Long-term cohort studies European Journal of Heart Failure

Key finding: We identified all participants in the UK Biobank cohort study diagnosed with HF prior to enrolment or during follow-up, who had disease occurrence data available from both primary and secondary care records (n = 9824). +4 more findings

• Diagnosis

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The Cortical Asymmetry Index for subtyping dementia patients

50/100 ✓ Peer-reviewed Cognitive tests and assessment European Radiology

Key finding: A total of 101 FTD patients (64 ± 8 years, 53 men), 230 AD patients (65 ± 10 years, 84 men), and 173 CTR (59 ± 15 years, 67 men) were studied. +4 more findings

• Diagnosis
• Biomarkers

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Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

39/100 ✓ Peer-reviewed Risk genes beyond APOE eLife

Key finding: We recently reported evidence that FAD mutations in APP and PSEN1 cause deficiencies in early steps in processive proteolysis of APP substrate C99 and that this results from stalled γ-secretase enzyme-substrate and/or enzyme-intermediate complexes. +2 more findings

• Genetics

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From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease

52/100 ✓ Peer-reviewed Risk factors Molecular Neurodegeneration

Key finding: RBD pathophysiology is not fully clarified yet, but clinical and basic science suggest that ɑ-syn pathology begins in the lower brainstem where REM atonia circuits are located, including the sublaterodorsal tegmental/subcoeruleus nucleus and the ventral medulla, then propagates rostrally to brain regions such as the substantia nigra, limbic system, cortex.

• Treatments
• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

Sundowning Syndrome in Dementia: Mechanisms, Diagnosis, and Treatment

43/100 ✓ Peer-reviewed Caregiving Journal of Clinical Medicine

Key finding: Therefore, patients with SS need very precise diagnostic workup aiming at defining the exact cause of the syndrome. +4 more findings

• Treatments
• Diagnosis

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Feasibility and Preliminary Efficacy of an Intervention to Support Long-Distance Family Caregivers of Older Adults with Dementia

38/100 ✓ Peer-reviewed Caregiving Clinical Gerontologist

Key finding: LDCs were recruited within the planned timeframe. +4 more findings

• Caregiving

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Clinical and metabolic profiles in behavioural frontotemporal dementia: Impact of age at onset

40/100 ✓ Peer-reviewed Getting a diagnosis Cortex

Key finding: Moreover, we supported our result using a correlation-based approach on clinical and metabolic variables. 101 bvFTD (62 prodromal bvFTD) were enrolled (EO-bvFTD: n = 36, prodromal n = 21; LO-bvFTD: n = 36, prodromal: n = 22; vLO-bvFTD: n = 29, prodromal: n = 19). +3 more findings

• Other Dementias

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Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT

76/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: 9,361 participants randomized; 4,232 completed long-term cognitive assessment over median 7-year follow-up +3 more findings

• Clinical Trials
• Early Stage
• Risk Factors

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Circulating metabolomic profile of the MIND diet and its relation to cognition in middle‐aged and older adults

47/100 ✓ Peer-reviewed Prevention trials iMetaOmics.

Key finding: The Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) diet has been related to a lower risk of dementia and better cognitive function. +3 more findings

• Lifestyle

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AI-powered model for accurate prediction of MCI-to-AD progression

51/100 ✓ Peer-reviewed Mild cognitive impairment Acta Pharmaceutica Sinica B

Key finding: The performance of the BiGRU model was rigorously compared with several machine-learning model baselines to evaluate its efficacy. +1 more finding

• Early Stage
• Digital Tools

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Use of sodium‐glucose cotransporter‐2 inhibitors and risk of dementia: A population‐based cohort study

45/100 ✓ Peer-reviewed How common it is Diabetes Obesity and Metabolism

Key finding: The final cohort included 47 335 new users of DPP-4i or SGLT-2i. +4 more findings

• Risk Factors

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Use of Digital Health Technologies for Dementia Care: Bibliometric Analysis and Report

67/100 ✓ Peer-reviewed Caregiving JMIR Mental Health

Key finding: A total of 704 records met the inclusion criteria for bibliometric analysis. +4 more findings

• Digital Tools

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Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates

50/100 ✓ Peer-reviewed Getting a diagnosis Brain

Key finding: We found a wide range of behavioural changes across FTD. +4 more findings

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Joint control of multiple food processing contaminants in Maillard reaction: A comprehensive review of health risks and prevention

42/100 ✓ Peer-reviewed Prevention and risk Comprehensive Reviews in Food Science and Food Safety

Key finding: There is an urgent need to address food safety concerns associated with multiple Maillard reaction‒derived chemical contaminants, such as acrylamide, heterocyclic aromatic amines, advanced glycation end products, and 5-hydroxymethylfurfural, which are present in processed foods. +2 more findings

• Prevention

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Detection of Alzheimer Neuropathology in Alzheimer and Non-Alzheimer Clinical Syndromes With Blood-Based Biomarkers

59/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: AD was common in both AD-related syndromes (110/125 [88%]) and FTLD-related syndromes (45/198 [23%]). +1 more finding

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source