Newest studies

Dementia in the MENA region uncharted challenges and emerging insights a literature review

38/100 ✓ Peer-reviewed Risk factors npj Dementia

Key finding: Dementia is rising sharply in the Middle East and North Africa region (MENA), with cases projected to increase by 367% by 2050. +4 more findings

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Are modifiable risk factors for dementia really modifiable?

32/100 ✓ Peer-reviewed Risk factors Current Opinion in Psychiatry

Key finding: The 2024 Lancet Commission estimates 45% of dementias worldwide are preventable if 14 potentially modifiable risk factors for dementia were eliminated. +1 more finding

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Machine learning applied to mild cognitive impairment: bibliometric and visual analysis from 2015 to 2024

40/100 ✓ Peer-reviewed Digital health tools Frontiers in Neurology

Key finding: A total of 2056 papers related to machine learning in patients with MCI were retrieved from the Wo SCC database. +4 more findings

• Digital Tools
• Early Stage

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Diagnostic performance of actigraphy in Alzheimer’s disease using a machine learning classifier – a cross-sectional memory clinic study

51/100 ✓ Peer-reviewed Digital health tools Alzheimer s Research & Therapy

Key finding: Actigraphy accurately identifies different dementia etiologies and could serve as a supplement to diagnostic investigations in patients with suspected AD for differential diagnostic purposes.

• Digital Tools
• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Prevalence and risk factors of mild cognitive impairment and dementia in northern Peru

53/100 ✓ Peer-reviewed How common it is Frontiers in Public Health

Key finding: According to the results, 31.4% of the sample consisted of subjects without cognitive impairment, 40.5% were identified as possible cases of MCI, and 24.9% as possible cases of dementia. +4 more findings

• Risk Factors
• Early Stage

Full summary, score breakdown and related studies → Original source

Association between sacubitril/valsartan and risk of dementia in patients with heart failure: a nationwide cohort study

52/100 ✓ Peer-reviewed How common it is European Heart Journal - Cardiovascular Pharmacotherapy

Key finding: We conducted a retrospective cohort study using the National Health Insurance Database in South Korea. +4 more findings

• Risk Factors

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Mind Care: The Moral Significance of the Dementia Caregiving Dyad

44/100 ✓ Peer-reviewed Caregiving The American Journal of Bioethics

Key finding: We then suggest that mental extension may also be related to the support of the self and the moral person. +1 more finding

• Caregiving

Full summary, score breakdown and related studies → Original source

The diagnostic accuracy of CTseg segmentation software for dementia in a New Zealand memory service

34/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer s Disease Reports

Key finding: Our findings suggest that CTseg automated volumetric analysis has some potential to aid dementia diagnosis in real-world clinical settings.

• Diagnosis

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Diet and nutrition in cardiovascular disease prevention: a scientific statement of the European Association of Preventive Cardiology and the Association of Cardiovascular Nursing & Allied Professions of the European Society of Cardiology

49/100 ✓ Peer-reviewed Prevention and risk European Journal of Preventive Cardiology

Key finding: Balanced distribution of caloric intake through different meals is associated with favourable effects. +1 more finding

• Lifestyle
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: Anti-amyloid immunotherapy is used to treat Alzheimer disease (AD) with moderate benefits and potentially serious side effects due to amyloid related imaging abnormality with effusions/edema (ARIA-E). +3 more findings

• Treatments
• Brain Biology

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cost-utility analysis of the DREAMS START intervention for people living with dementia and their carers: a within-trial economic evaluation

62/100 ✓ Peer-reviewed Costs and economics The Lancet Healthy Longevity

Key finding: We aimed to conduct a cost-utility analysis of DREAMS START compared with treatment as usual (TAU). +3 more findings

• Policy
• Clinical Trials

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Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases

42/100 ✓ Peer-reviewed Disease mechanisms Molecular Aspects of Medicine

Key finding: A wide range of human diseases are associated with protein misfolding and amyloid aggregates. +1 more finding

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BIOMARCADORES PLASMÁTICOS NA DETECÇÃO PRECOCE DA DOENÇA DE ALZHEIMER: UMA REVISÃO SISTEMÁTICA

26/100 ✓ Peer-reviewed Tau biomarkers Cognitus Interdisciplinary Journal

Key finding: Os biomarcadores analisados incluíram NfL, p-Tau181, p-Tau217, Aβ42/Aβ40 e GFAP. +4 more findings

• Biomarkers

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About genotype and allele distributions of APP promoter single-nucleotide polymorphisms

37/100 ✓ Peer-reviewed Risk genes beyond APOE INTERNATIONAL NEUROLOGICAL JOURNAL

Key finding: The obtained data is noteworthy. +3 more findings

• Genetics
• Digital Tools

Full summary, score breakdown and related studies → Original source

Projected Demographic Trends in the Likelihood of Having or Becoming a Dementia Family Caregiver in the U.S. Through 2060

38/100 ✓ Peer-reviewed Disparities Populations

Key finding: Our model projections suggest that future dementia cohorts will be more likely to have a living spouse than the current ones, with diminishing gender disparities due to increased male longevity. +1 more finding

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source

Fluid biomarkers in atypical Parkinsonism: current state and future perspectives

36/100 ✓ Peer-reviewed Tau biomarkers Journal of neural transmission (Vienna, Austria : 1996)

Key finding: Fluid biomarkers can be useful tools that make it easier to identify and track different APS. +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Incidence and prevalence of dementia among US Medicare beneficiaries, 2015-21: population based study

61/100 ✓ Peer-reviewed How common it is BMJ

Key finding: The overall age and sex standardized incidence decreased between 2015 and 2021 from 3.5% to 2.8%. +1 more finding

• Risk Factors
• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Anti-Amyloid Agents: A Self-Fulfilling prophecy

43/100 ✓ Peer-reviewed Treatments Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Key finding: However, despite being fully aligned with these criteria-and therefore with how we define the disease-amyloid-targeting therapies have not yielded the expected results.

• Treatments

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Comparative efficacy, tolerability, and acceptability of aducanumab, lecanemab, and donanemab with repetitive transcranial magnetic stimulation on cognitive function in mild cognitive impairment and Alzheimer's disease: A systematic review and network meta-analysis

82/100 ✓ Peer-reviewed Treatments Journal of psychopharmacology (Oxford, England)

Key finding: Nineteen randomized placebo-controlled trials with 6918 participants were included. rTMS was significantly more effective than placebo/sham stimulation. +4 more findings

• Treatments

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Potentially Inappropriate Medication Use Among Patients With Dementia in Traditional Medicare and Medicare Advantage

30/100 ✓ Peer-reviewed Health systems and care delivery Medical Care

Key finding: MA-PD enrollees had significantly lower utilization of PIMs than standalone PDP enrollees: a 0.7 percentage-point [95% CI: 0.5, 0.8] lower prevalence of potentially harmful drug-disease interactions in older adults with dementia; a 3.1 percentage-point [2.6, 3.5] lower prevalence of potentially harmful drug-disease interactions in older adults with dementia and a history of falls; and a 0.5 percentage-point [0.4, 0.6] lower prevalence of high-risk medications in older adults. +2 more findings

• Treatments
• Policy

Full summary, score breakdown and related studies → Original source

Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s Disease

39/100 ✓ Peer-reviewed Inflammation and the immune system ASN NEURO

Key finding: Here, we show that proliferation results in profound alterations of cellular function by providing evidence that newly proliferated microglia show impaired beta-amyloid clearance in vivo. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

The Role of TDP-43 in SARS-CoV-2-Related Neurodegenerative Changes

39/100 ✓ Peer-reviewed Brain tissue and pathology Viruses

Key finding: Evidence from both clinical and experimental studies indicates that SARS-CoV-2 infection may contribute to long-term neurological sequelae, including amyotrophic lateral sclerosis-like and frontotemporal dementia-like features, as well as increased phosphorylated TDP-43 deposition in the central nervous system. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Health inequalities in disease burden of dementia and early-onset dementia: findings from the Global Burden of Disease 2021 study

41/100 ✓ Peer-reviewed Disparities Global Health Research and Policy

Key finding: Although the ASPR and ASIR remained stable or decreased globally, they both greatly increased in East Asia (ASPR: EAPC = 0.43; 95% CI 0.35, 0.51; ASIR: EAPC = 0.40; 95% CI 0.33, 0.47). +4 more findings

• Health Equity

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Global mortality, prevalence and disability-adjusted life years of Alzheimer’s disease and other dementias in adults aged 60 years or older, and the impact of the COVID-19 pandemic: a comprehensive analysis for the global burden of disease 2021

47/100 ✓ Peer-reviewed Disparities BMC Psychiatry

Key finding: In 2021, global mortality from AD and other dementias among individuals aged 60 and older reached approximately 1,922,970.75 cases (95% CI: 480,348.08 to 5,104,315.95), and the prevalence was 52,560,253.51 cases (95% CI: 41,399,948.84 to 65,633,448.71). +4 more findings

• Health Equity

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Impact of Neuropsychiatric Symptoms on Caregiver Burden of People With Dementia With Lewy Bodies: A Multicentre Prospective Longitudinal Study

37/100 ✓ Peer-reviewed Caregiving Psychogeriatrics

Key finding: At the initial visit, the mean age of individuals with DLB was 80.8 (5.8) years; their mean Mini-Mental State Examination score was 20.6 (5.1). +4 more findings

• Caregiving
• Other Dementias

Full summary, score breakdown and related studies → Original source