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This is our own score, not an official one

No journal, publisher or ranking body endorses it. It is not an impact factor, and it is not only a citation count: 28 of its 100 points come from how often the study itself has been cited. We built it so that someone who has never read a paper can tell a landmark trial from a conference abstract without already knowing the difference. Every point is attributable to one of 20 named components, printed on the study itself, so you can disagree with our arithmetic instead of having to trust a total.

The 20 things we score

The 100 points are split 20 ways, in 4 groups. The split is a judgement, and here it is in full.

When we have no data. If a study's record does not say something, such as how many people took part, that part scores zero, but if we simply have no data for a part, such as how often the study has been cited, we leave that part out and score the study on the parts we could check. 15,506 of the 27,780 studies are scored on fewer than all 20 parts, and each of those study cards says how many.

Versions. Version 1.0 had 6 components: journal, design, strength of evidence, peer review, recency, and a combined size-and-precision score. Version 2.0 (8 October 2026) had 9: it replaced size-and-precision with sample size, and added effect reported, studied in people, and randomised or blinded. Version 3.0 (10 October 2026) had 19: it added how often other researchers cite the study, who did it, and whether a reader can find and read it, and gave the first nine smaller ceilings. Version 4.0 (29 October 2026), the current one, has 20: it added the journal's own citation record, and stopped counting a gap in our data as a zero. Under version 2.0, 5,682 of 15,290 records (37%) had the same score on every component, because most records leave design, size and effect blank, which is why version 3.0 added parts that read data 94–100% of records had.

Where the points come from

The library is strongest on peer-review validation (97.7% of the points on offer) and weakest on randomised / blinded (3.8%).

Average points earned per score component, against each component's maximumJournal tier 7.2 of 10 (72.5 per cent); Journal's citation record 2.2 of 4 (53.9 per cent); Study design 2.2 of 12 (18.4 per cent); Strength of evidence 1.8 of 5 (36.3 per cent); Peer-review validation 9.8 of 10 (97.7 per cent); How recent 2.3 of 5 (46.3 per cent); Sample size 0.7 of 4 (17.7 per cent); Effect reported 0.4 of 3 (13.7 per cent); Studied in people 1.1 of 3 (36.8 per cent); Randomised / blinded 0.1 of 2 (3.8 per cent); Times cited 3.8 of 7 (54.4 per cent); Citations per year 2.3 of 5 (46.6 per cent); Impact for its field and year 3.2 of 6 (52.8 per cent); Cited by studies here 1.4 of 6 (23.9 per cent); Still being cited 1.7 of 4 (41.5 per cent); Senior author's track record 2.6 of 4 (66.4 per cent); Institution's track record 1.4 of 3 (47.5 per cent); Multi-centre collaboration 1.4 of 3 (45 per cent); Indexed in PubMed 1.9 of 2 (96 per cent); Free to read 0.8 of 2 (38.3 per cent).0510points earned, out of the component's maximumJournal tier7.2/10 · 72.5%Journal's citation record2.2/4 · 53.9%Study design2.2/12 · 18.4%Strength of evidence1.8/5 · 36.3%Peer-review validation9.8/10 · 97.7%How recent2.3/5 · 46.3%Sample size0.7/4 · 17.7%Effect reported0.4/3 · 13.7%Studied in people1.1/3 · 36.8%Randomised / blinded0.1/2 · 3.8%Times cited3.8/7 · 54.4%Citations per year2.3/5 · 46.6%Impact for its field and year3.2/6 · 52.8%Cited by studies here1.4/6 · 23.9%Still being cited1.7/4 · 41.5%Senior author's track record2.6/4 · 66.4%Institution's track record1.4/3 · 47.5%Multi-centre collaboration1.4/3 · 45%Indexed in PubMed1.9/2 · 96%Free to read0.8/2 · 38.3%filled = average earned · pale = the rest of the maximumn = 27780 studies · one axis, in points, starting at zeroa longer bar means the component is worth more, not that it scored better

This chart is wider than your screen — drag it sideways, or open the table underneath, which has every number in it.

n = 27780 studies. Each average is the mean of that component's points across the studies it was scored on. Where we have no data for a study, that component is left out of its score, so it is left out of the average too; the table says how many. The wording under each row is the record's own explanation, quoted from a study that sits closest to the average, with the names of authors and institutions taken out.
Every number in this chart, as a table
ComponentAverage earnedMaximumShare of the maximumStudies scored on itStudies with no data (left out)
Journal tier7.21072.5%27,7800
Journal's citation record2.2453.9%15,45112,329
Study design2.21218.4%27,7800
Strength of evidence1.8536.3%27,523257
Peer-review validation9.81097.7%27,7800
How recent2.3546.3%27,7764
Sample size0.7417.7%27,7800
Effect reported0.4313.7%27,7800
Studied in people1.1336.8%27,7800
Randomised / blinded0.123.8%27,7800
Times cited3.8754.4%15,00012,780
Citations per year2.3546.6%14,99612,784
Impact for its field and year3.2652.8%14,74413,036
Cited by studies here1.4623.9%15,24912,531
Still being cited1.7441.5%15,00012,780
Senior author's track record2.6466.4%13,45914,321
Institution's track record1.4347.5%14,59713,183
Multi-centre collaboration1.4345%15,31712,463
Indexed in PubMed1.9296%27,7800
Free to read0.8238.3%23,2654,515

Read across each row: the pale track is the most that component can be worth, and the filled part is what the average study in our library actually earns. The sentence under each one is the explanation a real record in the library carries, as the score wrote it, with the names of authors and institutions taken out.

  1. Journal tier up to 10 points

    Which journal published it, placed in ordered tiers — never a numeric impact factor.

    Across the 27,780 studies it is scored on, it averages 7.3 of 10 (72.5% of the points on offer). For 3 studies the record does not state it, so it scores zero there — and the card says so.

    The scoreable level nearest that average is 7 of 10, which 21,033 of those 27,780 studies sit on. One of them explains itself like this: Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD).

  2. Journal's citation record up to 4 points

    How much the journal's papers are cited over its whole life (its h-index in OpenAlex). It grades the many journals our tiers lump together. Old, large journals do best, so it is a track record, not a guarantee.

    Across the 15,451 studies it is scored on, it averages 2.2 of 4 (53.9% of the points on offer). For 12,329 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 2 of 4, which 4,515 of those 15,451 studies sit on. One of them explains itself like this: Alzheimer's & Dementia: journal h-index 228 (OpenAlex, 2026-10-29).

  3. Study design up to 12 points

    How the study was built: a pooled review of many trials tells you more than one snapshot.

    Across the 27,780 studies it is scored on, it averages 2.2 of 12 (18.4% of the points on offer). For 20,234 studies the record does not state it, so it scores zero there — and the card says so.

    The scoreable level nearest that average is 3 of 12, which 20 of those 27,780 studies sit on. One of them explains itself like this: A computer model rather than new measurements. The level the most studies actually sit on is a different one — 0 of 12, shared by 20,234 of the 27,780: No study design recorded — scores zero, not guessed.

  4. Strength of evidence up to 5 points

    How firm the finding is in our own summary of it, from preliminary up to high.

    Across the 27,523 studies it is scored on, it averages 1.8 of 5 (36.3% of the points on offer). For 257 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 2 of 5, which 64 of those 27,523 studies sit on. One of them explains itself like this: Rated “early” in our summary. The level the most studies actually sit on is a different one — 1 of 5, shared by 19,189 of the 27,523: Rated “low” in our summary.

  5. Peer-review validation up to 10 points

    Whether other scientists checked it before publication.

    Across the 27,780 studies it is scored on, it averages 9.8 of 10 (97.7% of the points on offer).

    The scoreable level nearest that average is 10 of 10, which 26,746 of those 27,780 studies sit on. One of them explains itself like this: Peer-reviewed. Published as an article in a named peer-reviewed journal.

  6. How recent up to 5 points

    How close it is to the newest study we carry.

    Across the 27,776 studies it is scored on, it averages 2.3 of 5 (46.3% of the points on offer). For 4 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 2 of 5, which 4,795 of those 27,776 studies sit on. One of them explains itself like this: 2020 — within 10 years of the newest study here. The level the most studies actually sit on is a different one — 1 of 5, shared by 11,795 of the 27,776: 2015 — within 20 years of the newest study here.

  7. Sample size up to 4 points

    How many people were in it, in bands: a blank count scores nothing.

    Across the 27,780 studies it is scored on, it averages 0.7 of 4 (17.7% of the points on offer). For 18,260 studies the record does not state it, so it scores zero there — and the card says so.

    The scoreable level nearest that average is 1 of 4, which 3,028 of those 27,780 studies sit on. One of them explains itself like this: 20 participants. The level the most studies actually sit on is a different one — 0 of 4, shared by 18,260 of the 27,780: Participant count not stated — scores zero.

  8. Effect reported up to 3 points

    Whether it reports how big the effect was, and with an interval or test rather than a bare number.

    Across the 27,780 studies it is scored on, it averages 0.4 of 3 (13.7% of the points on offer). For 22,790 studies the record does not state it, so it scores zero there — and the card says so.

    The scoreable level nearest that average is 0 of 3, which 22,792 of those 27,780 studies sit on. One of them explains itself like this: No effect size reported — scores zero.

  9. Studied in people up to 3 points

    Whether the record shows it was done in people, not in mice or a dish.

    Across the 27,780 studies it is scored on, it averages 1.1 of 3 (36.8% of the points on offer). For 16,118 studies the record does not state it, so it scores zero there — and the card says so.

    The scoreable level nearest that average is 0 of 3, which 17,563 of those 27,780 studies sit on. One of them explains itself like this: Not stated whether this was studied in people — scores zero.

  10. Randomised / blinded up to 2 points

    Whether the study itself says it was randomised, and whether it was blinded.

    Across the 27,780 studies it is scored on, it averages 0.1 of 2 (3.8% of the points on offer). For 24,647 studies the record does not state it, so it scores zero there — and the card says so.

    The scoreable level nearest that average is 0 of 2, which 26,177 of those 27,780 studies sit on. One of them explains itself like this: No randomisation or blinding stated — scores zero.

  11. Times cited up to 7 points

    How many times other papers have cited it, as counted by OpenAlex, in bands.

    Across the 15,000 studies it is scored on, it averages 3.8 of 7 (54.4% of the points on offer). For 12,780 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 4 of 7, which 1,872 of those 15,000 studies sit on. One of them explains itself like this: Cited 66 times (OpenAlex, 2026-10-10). The level the most studies actually sit on is a different one — 5 of 7, shared by 3,939 of the 15,000: Cited 116 times (OpenAlex, 2026-10-10).

  12. Citations per year up to 5 points

    Citations per year since it came out, so a new paper is not judged against a thirty-year head start.

    Across the 14,996 studies it is scored on, it averages 2.3 of 5 (46.6% of the points on offer). For 12,784 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 2 of 5, which 2,841 of those 14,996 studies sit on. One of them explains itself like this: 3.0 citations a year over 3 years since 2025. The level the most studies actually sit on is a different one — 3 of 5, shared by 3,888 of the 14,996: 8.3 citations a year over 3 years since 2025.

  13. Impact for its field and year up to 6 points

    OpenAlex's field-weighted citation impact: its citations against the average for papers of the same field and year.

    Across the 14,744 studies it is scored on, it averages 3.2 of 6 (52.8% of the points on offer). For 13,036 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 3 of 6, which 4,459 of those 14,744 studies sit on. One of them explains itself like this: Cited 4.7× the average for papers of its field and year (OpenAlex FWCI).

  14. Cited by studies here up to 6 points

    How many other studies in this library cite it, counted from the reference lists of the studies we hold.

    Across the 15,249 studies it is scored on, it averages 1.4 of 6 (23.9% of the points on offer). For 12,531 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 1 of 6, which 2,581 of those 15,249 studies sit on. One of them explains itself like this: Cited by 1 other study in this library. The level the most studies actually sit on is a different one — 0 of 6, shared by 5,533 of the 15,249: No other study in this library cites it.

  15. Still being cited up to 4 points

    How often it was cited in the last three calendar years: is the field still using it?

    Across the 15,000 studies it is scored on, it averages 1.7 of 4 (41.5% of the points on offer). For 12,780 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 2 of 4, which 4,126 of those 15,000 studies sit on. One of them explains itself like this: Cited 16 times in 2024–2026 (2026 still in progress; OpenAlex).

  16. Senior author's track record up to 4 points

    The last-listed (usually senior) author's career h-index in OpenAlex. A track record, not a guarantee.

    Across the 13,459 studies it is scored on, it averages 2.7 of 4 (66.4% of the points on offer). For 14,321 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 3 of 4, which 4,477 of those 13,459 studies sit on. One of them explains itself like this: The last-listed author has a career h-index of 94 (OpenAlex).

  17. Institution's track record up to 3 points

    The h-index of the strongest institution on the paper, from OpenAlex. A track record, not a guarantee.

    Across the 14,597 studies it is scored on, it averages 1.4 of 3 (47.5% of the points on offer). For 13,183 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 1 of 3, which 5,227 of those 14,597 studies sit on. One of them explains itself like this: The strongest institution on the paper has an h-index of 1,477 (OpenAlex).

  18. Multi-centre collaboration up to 3 points

    How many institutions took part. Work repeated across several centres is harder to get by chance.

    Across the 15,317 studies it is scored on, it averages 1.4 of 3 (45% of the points on offer). For 12,463 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 1 of 3, which 4,897 of those 15,317 studies sit on. One of them explains itself like this: OpenAlex lists 2 institutions in 1 country. The level the most studies actually sit on is a different one — 2 of 3, shared by 5,462 of the 15,317: OpenAlex lists 4 institutions in 1 country.

  19. Indexed in PubMed up to 2 points

    Whether PubMed indexes it, or failing that it has a DOI, so a reader can find and check it.

    Across the 27,780 studies it is scored on, it averages 1.9 of 2 (96% of the points on offer). For 96 studies the record does not state it, so it scores zero there — and the card says so.

    The scoreable level nearest that average is 2 of 2, which 25,655 of those 27,780 studies sit on. One of them explains itself like this: Indexed in PubMed (PMID 31413141).

  20. Free to read up to 2 points

    Whether anyone can read the full paper for free. This is about access, not quality.

    Across the 23,265 studies it is scored on, it averages 0.8 of 2 (38.3% of the points on offer). For 4,515 studies we have no data for it, so it is left out of their score.

    The scoreable level nearest that average is 0 of 2, which 14,352 of those 23,265 studies sit on. One of them explains itself like this: Behind a paywall — scores zero.

Why some entries stop at 16

A conference abstract, a preprint, a company press release and a regulator's notice are all worth reading. None of them has been through peer review. So the rubric caps every one of them at 16 out of 100 and gives it a warning chip, which means no non-peer-reviewed entry can ever outrank a peer-reviewed paper in our library — not as a convention we try to hold to, but as arithmetic.

How the scores are spread

Every study in the library, in 5-point bins. Median 46, range 9–93.

Distribution of alzhub scores across the study libraryHistogram of 27780 study scores in 5-point bins, from 9 to 93, median 46. A vertical line at 16 marks the peer-review cap: the 1034 entries that are not peer-reviewed research articles cannot score above it.0100020003000400050000102030405060708090100Peer-review cap: 16alzhub score (points out of 100)number of studiesn = 27780 studies · 5-point bins · both axes start at zero1034 entries are not peer-reviewed research articles; none can score past the line at 16.

This chart is wider than your screen — drag it sideways, or open the table underneath, which has every number in it.

n = 27780 studies — the whole library. The scores are computed from the study records we hold, and the counts are read from the same data. The line at 16 is the peer-review cap: 1034 entries are not peer-reviewed research articles, and the rubric stops them there by construction, so none can outrank a peer-reviewed paper. The lowest-scoring peer-reviewed article in the library scores 21.
Every number in this chart, as a table
Score rangeStudies
0–40
5–91
10–1418
15–191015
20–2431
25–29363
30–34711
35–394652
40–445768
45–494206
50–543412
55–592709
60–641927
65–691364
70–74902
75–79463
80–84191
85–8944
90–943
95–990

The number 16 is not a round guess. The lowest-scoring peer-reviewed article we carry scores 21, so the cap sits below it with room to spare. If a peer-reviewed study ever scored 16 or less, the scoring step would stop and publish no new scores until the cap was fixed. Of the 1034 entries that are not peer-reviewed, 997 scored high enough on the other components to be pulled down by the cap; the rest were already below it. On those 997 study cards we print the raw total as well as the capped one, so you can see exactly what the cap cost.

What the library actually looks like

A score tells you about one study. These two charts tell you about the pile: which subjects we hold strong evidence on, and — the thing a single number hides — what kinds of study that evidence is actually made of.

Which subjects rest on stronger evidence

Each subject's median score, with the middle half of its studies as a bar and its full range as a line.

Score by subject area: count, median and the middle half of the scoresClinical trials, 162 studies, median 61, middle half 43 to 76; How common it is, 522 studies, median 57, middle half 50 to 63; Laboratory science, 46 studies, median 56.5, middle half 48.2 to 62.8; Prevention and risk, 1004 studies, median 55, middle half 46 to 65; Getting a diagnosis, 815 studies, median 54, middle half 46 to 61; Long-term cohort studies, 542 studies, median 54, middle half 48 to 60; Lewy body dementia, 566 studies, median 51, middle half 45.2 to 56; Treatments, 1489 studies, median 50, middle half 40 to 64; Caregiving, 834 studies, median 50, middle half 43 to 60; Cognitive tests and assessment, 881 studies, median 49, middle half 43 to 57; Disparities, 833 studies, median 49, middle half 42 to 57; Mild cognitive impairment, 701 studies, median 49, middle half 44 to 57; Biomarkers, 2195 studies, median 48, middle half 40 to 58; Prevention trials, 835 studies, median 48, middle half 40 to 67; Brain tissue and pathology, 612 studies, median 48, middle half 41 to 54; TREM2 and immune genetics, 701 studies, median 47, middle half 43 to 53; Genetics, 1616 studies, median 46, middle half 40 to 55; Brain scans and imaging, 1459 studies, median 46, middle half 39 to 53; Digital health tools, 1094 studies, median 46, middle half 41 to 54; Costs and economics, 199 studies, median 46, middle half 40 to 57; Tau biomarkers, 690 studies, median 45, middle half 39 to 52; Clinical safety, 630 studies, median 45, middle half 37 to 55; Inflammation and the immune system, 868 studies, median 43, middle half 40 to 49; End-of-life care, 855 studies, median 43, middle half 37 to 53; Risk genes beyond APOE, 847 studies, median 43, middle half 39 to 47; Hippocampus size on brain scans, 492 studies, median 43, middle half 36 to 52; Risk factors, 2174 studies, median 42, middle half 37.2 to 53; Vascular contributions, 546 studies, median 42, middle half 38 to 52; Disease mechanisms, 1381 studies, median 40, middle half 36 to 43; Drug development, 873 studies, median 40, middle half 36 to 43; Health systems and care delivery, 654 studies, median 40, middle half 35 to 47; Down syndrome and Alzheimer's, 664 studies, median 39, middle half 35 to 43.020406080100alzhub score (points out of 100)Clinical trials (162)How common it is (522)Laboratory science (46)Prevention and risk (1004)Getting a diagnosis (815)Long-term cohort studies(542)Lewy body dementia (566)Treatments (1489)Caregiving (834)Cognitive tests andassessment (881)Disparities (833)Mild cognitive impairment(701)Biomarkers (2195)Prevention trials (835)Brain tissue and pathology(612)TREM2 and immune genetics(701)Genetics (1616)Brain scans and imaging(1459)Digital health tools (1094)Costs and economics (199)Tau biomarkers (690)Clinical safety (630)Inflammation and the immunesystem (868)End-of-life care (855)Risk genes beyond APOE(847)Hippocampus size on brainscans (492)Risk factors (2174)Vascular contributions(546)Disease mechanisms (1381)Drug development (873)Health systems and caredelivery (654)Down syndrome andAlzheimer's (664)middle half of the scores (25th–75th)medianfull range, lowest to highestn = 27780 studies across 32 subjects · axis is the full 0–100 score, from zero

This chart is wider than your screen — drag it sideways, or open the table underneath, which has every number in it.

n = 27780 studies in 32 subjects, counted from the scored library. The bar is the interquartile range — a quarter of the subject's studies score below it and a quarter above. A high median means the studies we carry on that subject are strong ones, not that the subject itself is settled.
Every number in this chart, as a table
SubjectStudiesLowest25th percentileMedian75th percentileHighestPeer-reviewed
Clinical trials1621643617688145
How common it is5221650576385490
Laboratory science461248.256.562.88043
Prevention and risk10041646556587979
Getting a diagnosis8151646546179789
Long-term cohort studies5421648546080526
Lewy body dementia5661645.2515671547
Treatments148910405064901432
Caregiving8341643506083816
Cognitive tests and assessment8811043495784849
Disparities8331642495779808
Mild cognitive impairment7011644495777685
Biomarkers219511404858912102
Prevention trials8351640486793821
Brain tissue and pathology6121041485480587
TREM2 and immune genetics7011643475385684
Genetics161610404655861528
Brain scans and imaging145916394653861385
Digital health tools109416414654851044
Costs and economics1991640465782180
Tau biomarkers6901639455288661
Clinical safety6301637455586616
Inflammation and the immune system8681640434981852
End-of-life care8551337435386839
Risk genes beyond APOE8471039434773824
Hippocampus size on brain scans4923636435284492
Risk factors21741137.24253892065
Vascular contributions5461238425284529
Disease mechanisms138112364043791334
Drug development8731536404389823
Health systems and care delivery654935404786631
Down syndrome and Alzheimer's6641635394374640

A high median here means the studies we carry on that subject score well. It does not mean the subject is settled, and it does not mean we have all of it. We hold 32 subjects and 46–2195 studies in each.

What kinds of study each subject rests on

Laboratory science is the most observational: 20 of its 46 studies watch what happens rather than test a change.

Mix of study designs within each subject areaLaboratory science, 46 studies: Randomised controlled trial 1, Phase 2 or phase 3 trial 1, Cohort study 15, Case-control 4, Cross-sectional 1, Other or not recorded 24; Biomarkers, 2195 studies: Meta-analysis 22, Phase 2 or phase 3 trial 1, Cohort study 24, Cross-sectional 219, Other or not recorded 1929; Costs and economics, 199 studies: Systematic review 2, Meta-analysis 2, Randomised controlled trial 6, Cohort study 10, Cross-sectional 11, Other or not recorded 168; Disparities, 833 studies: Meta-analysis 16, Cross-sectional 79, Other or not recorded 738; Caregiving, 834 studies: Systematic review 2, Meta-analysis 43, Randomised controlled trial 13, Cohort study 2, Cross-sectional 73, Other or not recorded 701; Long-term cohort studies, 542 studies: Meta-analysis 13, Cross-sectional 46, Other or not recorded 483; How common it is, 522 studies: Meta-analysis 21, Cohort study 12, Cross-sectional 31, Other or not recorded 458; End-of-life care, 855 studies: Meta-analysis 7, Cross-sectional 66, Other or not recorded 782; Cognitive tests and assessment, 881 studies: Meta-analysis 14, Cross-sectional 68, Other or not recorded 799; Hippocampus size on brain scans, 492 studies: Meta-analysis 19, Cross-sectional 37, Other or not recorded 436; Getting a diagnosis, 815 studies: Systematic review 4, Meta-analysis 18, Randomised controlled trial 2, Cohort study 5, Cross-sectional 52, Other or not recorded 734; Prevention and risk, 1004 studies: Systematic review 1, Meta-analysis 79, Randomised controlled trial 12, Phase 2 or phase 3 trial 1, Cohort study 45, Cross-sectional 25, Other or not recorded 841; Vascular contributions, 546 studies: Meta-analysis 12, Cross-sectional 37, Other or not recorded 497; Health systems and care delivery, 654 studies: Meta-analysis 6, Cross-sectional 44, Other or not recorded 604; Brain scans and imaging, 1459 studies: Meta-analysis 10, Cross-sectional 94, Other or not recorded 1355; Tau biomarkers, 690 studies: Meta-analysis 8, Cross-sectional 42, Other or not recorded 640; Risk factors, 2174 studies: Meta-analysis 70, Cross-sectional 124, Other or not recorded 1980; Mild cognitive impairment, 701 studies: Meta-analysis 12, Cross-sectional 37, Other or not recorded 652; Genetics, 1616 studies: Meta-analysis 74, Randomised controlled trial 1, Cohort study 14, Case-control 11, Cross-sectional 49, Other or not recorded 1467; Digital health tools, 1094 studies: Meta-analysis 16, Cross-sectional 46, Other or not recorded 1032; Prevention trials, 835 studies: Meta-analysis 42, Cross-sectional 30, Other or not recorded 763; Down syndrome and Alzheimer's, 664 studies: Meta-analysis 1, Cross-sectional 19, Other or not recorded 644; Clinical safety, 630 studies: Meta-analysis 24, Cross-sectional 18, Other or not recorded 588; Brain tissue and pathology, 612 studies: Meta-analysis 8, Cross-sectional 17, Other or not recorded 587; Lewy body dementia, 566 studies: Cross-sectional 11, Other or not recorded 555; Treatments, 1489 studies: Systematic review 2, Meta-analysis 45, Randomised controlled trial 3, Phase 2 or phase 3 trial 4, Cohort study 6, Case-control 1, Cross-sectional 15, Other or not recorded 1413; TREM2 and immune genetics, 701 studies: Meta-analysis 23, Cross-sectional 8, Other or not recorded 670; Disease mechanisms, 1381 studies: Meta-analysis 7, Cross-sectional 14, Other or not recorded 1360; Drug development, 873 studies: Meta-analysis 17, Cross-sectional 7, Other or not recorded 849; Clinical trials, 162 studies: Meta-analysis 1, Randomised controlled trial 2, Phase 2 or phase 3 trial 17, Cross-sectional 1, Other or not recorded 141; Risk genes beyond APOE, 847 studies: Meta-analysis 7, Cross-sectional 4, Other or not recorded 836; Inflammation and the immune system, 868 studies: Meta-analysis 12, Cross-sectional 3, Other or not recorded 853.0%25%50%75%100%share of that subject's studiesLaboratory science15424n = 46Biomarkers1929n = 2195Costs and economics168n = 199Disparities79738n = 833Caregiving701n = 834Long-term cohort studies483n = 542How common it is458n = 522End-of-life care782n = 855Cognitive tests andassessment799n = 881Hippocampus size on brainscans436n = 492Getting a diagnosis734n = 815Prevention and risk841n = 1004Vascular contributions497n = 546Health systems and caredelivery604n = 654Brain scans and imaging1355n = 1459Tau biomarkers640n = 690Risk factors1980n = 2174Mild cognitive impairment652n = 701Genetics1467n = 1616Digital health tools1032n = 1094Prevention trials763n = 835Down syndrome andAlzheimer's644n = 664Clinical safety588n = 630Brain tissue and pathology587n = 612Lewy body dementia555n = 566Treatments1413n = 1489TREM2 and immune genetics670n = 701Disease mechanisms1360n = 1381Drug development849n = 873Clinical trials17141n = 162Risk genes beyond APOE836n = 847Inflammation and the immunesystem853n = 868Systematic reviewMeta-analysisRandomised controlled trialPhase 2 or phase 3 trialCohort studyCase-controlCross-sectionalOther or not recordedDarker is higher up the evidence pyramid; grey is “we do not know”.n = 27780 studies · numbers inside the bars are study counts

This chart is wider than your screen — drag it sideways, or open the table underneath, which has every number in it.

n = 27780 studies. Each bar is one subject, split by the study design each record states, which is what the score reads. Bars are shares of that subject, so a short subject and a long one are comparable; the study count is printed at the end of every bar, and subjects with fewer than 5 studies are flagged. "Other or not recorded" is computer-modelling studies plus records with no design in them, which score zero for design rather than being guessed at.
Every number in this chart, as a table
SubjectStudiesSystematic reviewMeta-analysisRandomised controlled trialPhase 2 or phase 3 trialCohort studyCase-controlCross-sectionalOther or not recorded
Laboratory science460011154124
Biomarkers2195022012402191929
Costs and economics199226010011168
Disparities833016000079738
Caregiving8342431302073701
Long-term cohort studies542013000046483
How common it is5220210012031458
End-of-life care85507000066782
Cognitive tests and assessment881014000068799
Hippocampus size on brain scans492019000037436
Getting a diagnosis815418205052734
Prevention and risk100417912145025841
Vascular contributions546012000037497
Health systems and care delivery65406000044604
Brain scans and imaging14590100000941355
Tau biomarkers69008000042640
Risk factors217407000001241980
Mild cognitive impairment701012000037652
Genetics1616074101411491467
Digital health tools10940160000461032
Prevention trials835042000030763
Down syndrome and Alzheimer's66401000019644
Clinical safety630024000018588
Brain tissue and pathology61208000017587
Lewy body dementia56600000011555
Treatments14892453461151413
TREM2 and immune genetics70102300008670
Disease mechanisms1381070000141360
Drug development87301700007849
Clinical trials16201217001141
Risk genes beyond APOE8470700004836
Inflammation and the immune system86801200003853

This is the chart that a score cannot show you. Two subjects can have the same median and rest on completely different kinds of evidence: one on trials that changed something and measured what happened, the other on observation, which can tell you two things travel together but never that one caused the other. Where the bar is grey, the record does not state a design, and the rubric scores it zero rather than guessing.

What this score is not

It is not an official measure of quality. It is alzhub's own editorial rubric. No journal, publisher, funder or ranking body has reviewed it or endorsed it.

It is not only a citation metric. 28 of the 100 points come from citations: how often the study has been cited, how often per year, how that compares with papers of the same field and year, how many studies in this library cite it, and whether it is still being cited. Another 4 come from how much the journal's papers are cited. The other 68 points come from how the study was done, where it was published, who did it and whether a reader can find it. It is not an impact factor. Journals are placed in ordered tiers, never given an impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. The journal's citation record is its h-index as OpenAlex publishes it, stored with the date we read it. If you want the citation counts on their own, they are a separate page.

It is not a verdict on whether a study is right. A low score means we could see less of the things this rubric looks for — not that the finding is wrong. An early-phase trial in a small journal can be the study that matters most, and a 90-point paper can still turn out to be mistaken.

A null result is not a failure. We carry 23 studies whose finding is that something does not work, scoring between 16 and 87. They are in the library on purpose. Someone deciding whether to buy a supplement is served by a rigorous trial showing it does nothing, and our rubric ranks a null result above an early positive finding for exactly that reason — the rigour is already counted by the design and journal components, so demoting a null result would punish good science for reporting an inconvenient answer.

It is not a substitute for reading the study. Every card links to the original. The score is there to help you decide what to open, not to tell you what to think about it.

The full tables, so you can check the arithmetic

These are the lookup values the score uses: one table for each of the 20 components. A study's score is the points it earned out of the points it could be judged on, turned into a number out of 100. For a study we have data on for all 20 parts, that is simply the sum. Where a table says “left out”, that part is not counted for that study (see when we have no data). Anything that is not peer-reviewed is then capped at 16. Nothing else feeds the score.

Journal tier — up to 10 points
TierWhat it isPoints
Tier 1top-tier general journal10
Tier 2leading specialty journal9
Tier 3peer-reviewed journal7
Tier 4not a peer-reviewed journal2
Study design — up to 12 points
DesignPoints
A systematic review of all the studies on the question12
A meta-analysis pooling many studies12
A randomised controlled trial11
A large phase 3 trial11
A mid-stage phase 2 trial8
A cohort study following people over time7
A prospective cohort study, followed forward from enrollment7
A retrospective cohort study, reconstructed from past records7
A longitudinal study following the same people over time7
A case-control study6
A snapshot of people at one point in time4
A computer model rather than new measurements3
No design recorded0
Strength of evidence — up to 5 points
Rating in our summaryPoints
High5
Moderate3
Null result3
Early2
Preliminary2
Low1
No rating recordedleft out
Peer-review validation — up to 10 points
StatusWhat it meansPoints
Peer-reviewedA research article published in a peer-reviewed journal: other scientists reviewed it before it was published.10
Preprint — not yet peer-reviewedPosted publicly by its authors before any journal review. The findings may change or may never be published.4
Report — not peer-reviewedAn analysis published by an organisation under its own name. Useful, but it did not go through journal peer review.3
Conference abstract — not peer-reviewedA short summary presented at a conference. Conference abstracts are screened, not peer-reviewed, and often contain interim numbers that change before any full paper appears.3
Press release — not a studyAn announcement written by a company about its own results. There is no independent review and no full dataset to check.1
Regulatory decision — not a studyA decision or notice from a regulator (FDA, EMA, CMS, SEC). It is an official action, not a study — the evidence behind it lives in the trials it cites.1
Retracted — do not rely on itThe journal has withdrawn this paper, or this entry is the retraction notice itself. Retraction means the findings should not be relied on, so it is scored like a non-peer-reviewed source.0
Journal's citation record — up to 4 points
The journal's h-index (OpenAlex)Points
500 or more4
250 or more3
150 or more2
75 or more1
Below 750
Not a journal article0
No journal recordleft out

A journal's h-index is the largest number h such that h of its papers have each been cited at least h times.

How recent — up to 5 points
Publication yearPoints
Within 1 year of the newest study here5
Within 3 years of the newest study here4
Within 6 years of the newest study here3
Within 10 years of the newest study here2
Within 20 years of the newest study here1
Older than 20 years1
No year recordedleft out
Sample size — up to 4 points
ParticipantsPoints
10,000 or more participants4
1,000 or more participants3
100 or more participants2
1 or more participants1
Participant count not stated0
Effect reported — up to 3 points
What the record statesPoints
Effect size with a statistic (interval, p-value, ratio or similar)3
Effect size as a number only2
No effect size, or one given in words only0
Studied in people — up to 3 points
What the record statesPoints
A participant count, or a PubMed type used only for studies in people3
The title names an animal or lab model, or nothing shows it was done in people0
Randomised / blinded — up to 2 points
What the record states about the study itselfPoints
Randomised1
Blinded or placebo-controlled1
Neither stated, or a review of other studies0

The two points add together.

Times cited — up to 7 points
Times cited (OpenAlex)Points
1,000 or more7
300 or more6
100 or more5
40 or more4
15 or more3
5 or more2
1 or more1
Never cited0
No OpenAlex countleft out
Citations per year — up to 5 points
Citations a year since publicationPoints
50 or more a year5
20 or more a year4
8 or more a year3
3 or more a year2
1 or more a year1
Fewer than 1 a year0
No countleft out
Impact for its field and year — up to 6 points
Citations against the average for its field and yearPoints
40× the average or more6
20× the average or more5
8× the average or more4
3× the average or more3
1× the average or more2
Above 01
Zero0
No figure from OpenAlexleft out
Cited by studies here — up to 6 points
Studies in this library that cite itPoints
200 or more6
100 or more5
30 or more4
10 or more3
3 or more2
1 or more1
None0
Not yet checkedleft out
Still being cited — up to 4 points
Citations in the last three calendar yearsPoints
200 or more4
50 or more3
15 or more2
3 or more1
Fewer than 30
No yearly countsleft out
Senior author's track record — up to 4 points
Last-listed author's career h-index (OpenAlex)Points
100 or more4
50 or more3
20 or more2
5 or more1
Below 50
No recordleft out

An OpenAlex profile holding fewer than 10 works is left out, because new papers are often filed under a split-off profile.

Institution's track record — up to 3 points
Strongest institution's h-index (OpenAlex)Points
2,500 or more3
1,500 or more2
700 or more1
Below 7000
None listedleft out
Multi-centre collaboration — up to 3 points
Institutions on the paper (OpenAlex)Points
10 or more3
4 or more2
2 or more1
One0
Not listedleft out

A study PubMed indexes as multicentre gets at least 2.

Indexed in PubMed — up to 2 points
Where a reader can find itPoints
Indexed in PubMed2
Not in PubMed, but has a DOI1
Neither0
Free to read — up to 2 points
AccessPoints
Free to read2
Behind a paywall0
Not recordedleft out

Rubric version 4.0. Recency is measured against 2027, the newest year in the library, and not against today's date, so the same data always produces the same scores. Both the scores and the figures on this page are regenerated from the published data, where you can download both.

Back to the research library →    Newest studies first    What the library's numbers show