Newest studies

Gut microbiota and its metabolites in Alzheimer's disease: from pathogenesis to treatment

43/100 ✓ Peer-reviewed Disease mechanisms PeerJ

Key finding: Regulating the gut flora ecological balance upregulates neurotrophic factor expression, regulates the microbiota-gut-brain (MGB) axis, and suppresses the inflammatory responses. +1 more finding

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Cognitive resilience/reserve: Myth or reality? A review of definitions and measurement methods

55/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We evaluate-also in a critical way-the methods commonly used to define and measure CR, including sociobehavioral proxies, neuroimaging, and electrophysiological and genetic measures. +4 more findings

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Disease-Modifying Treatments and Their Future in Alzheimer's Disease Management

43/100 ✓ Peer-reviewed Drug development Cureus

Key finding: This narrative review investigates novel DMTs and their therapeutic targets that are either in phase three of development or have been recently approved by the U.S. +4 more findings

• Treatments
• Brain Biology

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APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia

50/100 ✓ Peer-reviewed Genetics Nature

Key finding: Our findings suggest a link between genetic risk factors for Alzheimer's disease with microglial lipid droplet accumulation and neurotoxic microglia-derived factors, potentially providing therapeutic strategies for Alzheimer's disease.

• Genetics
• Brain Biology

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Adapting prescribing criteria for amyloid‐targeted antibodies for adults with Down syndrome

48/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: This exclusion may deny DS adults access to potential disease-modifying treatments. +4 more findings

• Treatments
• Down Syndrome
• Policy

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CSF β-Amyloid and Tau Biomarker Changes in Veterans With Mild Traumatic Brain Injury

61/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Whether mild TBI (mTBI) in veterans confers a similar increased risk of AD is less known. +3 more findings

• Biomarkers
• Risk Factors

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Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation

47/100 ✓ Peer-reviewed TREM2 and immune genetics Science translational medicine

Key finding: The pathogenic mechanisms of MASH center on hepatocyte injury and the ensuing immune response within the liver microenvironment. +3 more findings

• Genetics

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Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons

46/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Neurons with lower basal UPS activity were more vulnerable to tau accumulation following mild UPS inhibition. +4 more findings

• Brain Biology

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TREM2 protects from atherosclerosis by limiting necrotic core formation

49/100 ✓ Peer-reviewed TREM2 and immune genetics Nature cardiovascular research

Key finding: Recent studies have identified Triggering receptor expressed on myeloid cells 2 (TREM2), a lipid-sensing receptor regulating myeloid cell functions [3], to be highly expressed in macrophage foam cells in experimental and human atherosclerosis [4]. +3 more findings

• Genetics

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Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology

56/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Midlife NAFLD shows associations with AD and accumulating vascular pathology, revealing potential pathways linking liver function to dementia. +1 more finding

• Biomarkers
• Brain Scans

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Empathy and support exchanges in couples coping with early-stage Alzheimer's disease

43/100 ✓ Peer-reviewed Caregiving Aging & mental health

Key finding: People with early-stage AD and their spousal caregivers provided support to each other often. +4 more findings

• Caregiving
• Early Stage

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Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer's pathology

59/100 ✓ Peer-reviewed Biomarkers EBioMedicine

Key finding: Both plasma p-tau217 assays were strongly associated with amyloid and tau PET.

• Biomarkers

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TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis

49/100 ✓ Peer-reviewed TREM2 and immune genetics International journal of biological sciences

Key finding: Osteoarthritis (OA) is the most prominent chronic arthritic disease, affecting over 3 billion people globally. +3 more findings

• Genetics

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Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy

58/100 ✓ Peer-reviewed Digital health tools Annals of neurology

Key finding: Clinical data alone poorly predicted phenoconversion in RBD due to synucleinopathy patients. +2 more findings

• Brain Scans
• Other Dementias
• Lifestyle

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Promoting diverse perspectives: Addressing health disparities related to Alzheimer's and all dementias

46/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Current research participants are primarily well-resourced, non-Hispanic White, cisgender adults who live close to academic medical centers where much of the research is based. +4 more findings

• Health Equity
• Risk Factors

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Anti-alpha synuclein and anti-tau immunotherapies: Can a cocktail approach work?

43/100 ✓ Peer-reviewed Drug development Parkinsonism & related disorders

Key finding: Already completed clinical trials have ranged from initially negative results to recently partial positive outcomes, specifically for anti-amyloid antibodies in AD but also albeit to lesser degree for anti-synuclein antibodies in PD.

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Comparison of prior authorization across insurers: cross sectional evidence from Medicare Advantage

49/100 ✓ Peer-reviewed Health systems and care delivery BMJ

Key finding: PA policies varied substantially across private insurers in the US. +2 more findings

• Policy

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Air pollution and neurological diseases, current state highlights

43/100 ✓ Peer-reviewed Risk factors Frontiers in neuroscience

Key finding: This paper delves into the increasingly recognized yet complex relationship between air pollution and Neurological Diseases. +4 more findings

• Risk Factors

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Palladium nanoballs coupled with smartphone-thermal reader for photothermal lateral flow immunoassay of Aβ 1-40

43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of materials chemistry. B

Key finding: Here, a palladium nanoball (PNB)-strip was developed and coupled with a smartphone-thermal reader as an ultrasensitive and cost-effective platform for Aβ 1-40 detection. +4 more findings

• Brain Biology
• Digital Tools

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Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer's disease

59/100 ✓ Peer-reviewed Treatments Frontiers in neurology

Key finding: Our results demonstrate that 1-h daily treatment with Cognito's Evoked Gamma Therapy System (CogTx-001) was safe and well-tolerated and demonstrated potential clinical benefits in mild to moderate AD. +2 more findings

• Treatments

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Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults

66/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Our findings suggest that statins might be associated with a lower risk of incident AD among individuals with the APOE ε4 allele. +4 more findings

• Genetics
• Risk Factors

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Preclinical Dementia and Economic Well-Being Trajectories of Racially Diverse Older Adults

43/100 ✓ Peer-reviewed Disparities Journal of aging and health

Key finding: Older adults classified with dementia were more likely to drop out of the labor force and become poor than similar older adults without dementia. +2 more findings

• Health Equity
• Early Stage
• Policy

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Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy

43/100 ✓ Peer-reviewed Disease mechanisms Neurochemistry international

Key finding: Western blot analysis in frozen tissue from the middle frontal gyrus revealed decreased levels of the presynaptic protein synaptophysin, but slightly increased levels of the postsynaptic density protein 95 (PSD95) in FTLD-TDP. +1 more finding

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma+/PET- demonstrated increased FW (24 regions) and decreased FAt (66 regions) compared to plasma-/PET-. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Breast cancer screening among Medicare Advantage enrollees with dementia

38/100 ✓ Peer-reviewed Health systems and care delivery BMC Health Services Research

Key finding: Mammogram utilization was 16% higher (Prevalence Ratio [PR] 1.16; 95% CI: 1.05, 1.29) among Medicare Advantage enrollees with dementia, compared to their counterparts in fee-for-service Medicare. +4 more findings

• Diagnosis
• Policy

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