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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 8,001–8,025 of 27,380 studies, newest first · page 321 of 1096.

January 2023 25

  1. 2023-01-30

    Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus

    ✓ Peer-reviewed Disease mechanisms Molecular brain

    Key finding: Previous studies of PS function in the hippocampus demonstrated that loss of PS results in the impairment of short- and long-term synaptic plasticity and neurotransmitter release at hippocampal Schaffer collateral (SC) and mossy fiber (MF) synapses. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2023-01-30

    HEDIS Measures for Geriatric Care Quality: Evidence, Equity, and a Governance Framework

    ✓ Peer-reviewed Health systems and care delivery Zenodo (CERN European Organization for Nuclear Research)

    Key finding: An equity monitoring protocol tracks performance stratified by race, ethnicity, and area deprivation, with a root-cause analysis requirement for identified gaps. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2023-01-30

    HEDIS Measures for Geriatric Care Quality: Evidence, Equity, and a Governance Framework

    ✓ Peer-reviewed Health systems and care delivery Zenodo (CERN European Organization for Nuclear Research)

    Key finding: An equity monitoring protocol tracks performance stratified by race, ethnicity, and area deprivation, with a root-cause analysis requirement for identified gaps. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2023-01-28

    The Crosstalk between Microbiome and Mitochondrial Homeostasis in Neurodegeneration

    ✓ Peer-reviewed Disease mechanisms Cells

    Key finding: Emerging evidence indicates that mitochondrial dysfunction and altered mitochondrial dynamics are crucial hallmarks of a wide variety of neurodevelopmental and neurodegenerative conditions.

    Full summary, score breakdown and related studies → Original source

  5. 2023-01-28

    Multiple Brain Tumor Classification with Dense CNN Architecture Using Brain MRI Images

    ✓ Peer-reviewed Digital health tools Life (Basel, Switzerland)

    Key finding: Open-source brain tumor images taken from the Kaggle database were used. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2023-01-28

    Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression-A Pilot Randomized Controlled Trial

    ✓ Peer-reviewed Treatments International journal of environmental research and public health

    Key finding: Transcranial pulse stimulation (TPS) is a recent development in non-invasive brain stimulations (NIBS) that has been proven to be effective in terms of significantly improving Alzheimer patients' cognition, memory, and execution functions. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2023-01-27

    Passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xTg-AD mice

    ✓ Peer-reviewed Drug development Experimental neurology

    Key finding: By screening monoclonal antibodies 43D, 63B, 39E10, and 77G7 that recognize epitopes ranging from tau's N-terminus to C-terminus, we found the 77G7, which targets the microtubule-binding domain promoted tau clearance in a dose-dependent manner by entering neuronal cells in vitro. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2023-01-27

    A meta-analysis investigating the relationship between inflammation in autoimmune disease, elevated CRP, and the risk of dementia

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in immunology

    Key finding: Inflammation is developing as the main focus of research into Alzheimer's disease and has been demonstrated to be a major driver of the pathologies associated with AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2023-01-26

    Information and Advance Care Directives for End-of-Life Residents with and without Dementia in Nursing Homes

    ✓ Peer-reviewed End-of-life care Healthcare (Basel, Switzerland)

    Key finding: A total of 54.4% of the residents with dementia had been provided with information about their state of health, compared to 92.5% of the residents without dementia (p < 0.01); family members exhibited no differences regarding information (p = 0.658), regardless of whether the resident was cognitively impaired. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2023-01-25

    Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer's Disease

    ✓ Peer-reviewed Genetics Cells

    Key finding: Collectively, our findings indicate that human ApoE isoforms differentially modulate neuronal glycolysis through HK regulation, with ApoE2 upregulating and ApoE4 downregulating, which markedly impacts neuronal health during aging. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2023-01-25

    Acute sleep loss decreases CSF-to-blood clearance of Alzheimer's disease biomarkers

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: These findings show that sleep loss alters some plasma AD biomarkers by lowering brain clearance mechanisms and needs to be taken into account when interpreting individual plasma AD biomarkers but not ratios. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2023-01-25

    The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials

    ✓ Peer-reviewed Treatments Alzheimer's research & therapy

    Key finding: The present findings provide evidence of the benefits of NIBS, especially tDCS, for beneficial effect on cognition in patients with AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2023-01-24

    [General aspects of dementia disorders]

    ✓ Peer-reviewed Caregiving Innere Medizin (Heidelberg, Germany)

    Key finding: Impairment of short-term memory is not always in the foreground and other neurocognitive domains, such as the disturbance of executive functions can have a significant impact on the ability to cope with everyday life. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2023-01-24

    BACE1 influences clinical manifestations and central inflammation in relapsing remitting multiple sclerosis

    ✓ Peer-reviewed Biomarkers Multiple sclerosis and related disorders

    Key finding: The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) has been associated with cognitive dysfunction, amyloid deposition and neuroinflammation in Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  15. 2023-01-24

    State-of-the-art therapy for Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Developmental medicine and child neurology

    Key finding: This is aggravated by a tendency to favour large-magnitude effects and highly significant findings, leading to high expectations but also to a biased view of the complex pathophysiology of Down syndrome.

    Full summary, score breakdown and related studies → Original source

  16. 2023-01-24

    Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Frontiers in neuroscience

    Key finding: The findings do not support an effect of the exercise intervention on a single measure of neurodegeneration in AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2023-01-23

    Impact of pre-analytical sample handling factors on plasma biomarkers of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Journal of neurochemistry

    Key finding: For routine clinical use, a biomarker must provide robust and reliable results under pre-analytical sample handling conditions.

    Full summary, score breakdown and related studies → Original source

  18. 2023-01-21

    Defective proteostasis in Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Ageing research reviews

    Key finding: Increasing evidence indicates that defective proteostasis contributes to the progression of neurodegenerative disorders, including Alzheimer's disease (AD), the most prevalent form of dementia in the elderly.

    Full summary, score breakdown and related studies → Original source

  19. 2023-01-21

    Robustness of CSF Aβ42/40 and Aβ42/P-tau181 measured using fully automated immunoassays to detect AD-related outcomes

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: For Aβ42/Aβ40, cutoffs across cohorts were <0.059 (BioFINDER), <0.057 (ADNI), and <0.058 (UCSF). +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2023-01-20

    Frontotemporal Dementia Patient Neurons With Progranulin Deficiency Display Protein Dyshomeostasis

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv : the preprint server for biology

    Key finding: PGRN is required for efficient proteostasis, as loss of neuronal PGRN results in dysfunctional lysosomes and impaired clearance and cytoplasmic aggregation of TDP-43, a protein involved in neurodegeneration in FTD. +1 more finding

    Scored 20 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2023-01-20

    A combined physiologically-based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease

    ✓ Peer-reviewed Treatments CPT: pharmacometrics & systems pharmacology

    Key finding: Apolipoprotein E genotype is implemented as a difference in microglia clearance. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2023-01-20

    TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology

    Key finding: Our recent results showed that overexpression of TREM2 inhibited inflammatory response in APP/PS1 mice and BV2 cells. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2023-01-19

    Virus exposure and neurodegenerative disease risk across national biobanks

    ✓ Peer-reviewed Long-term cohort studies Neuron

    Key finding: With recent findings connecting the Epstein-Barr virus to an increased risk of multiple sclerosis and growing concerns regarding the neurological impact of the coronavirus pandemic, we examined potential links between viral exposures and neurodegenerative disease risk. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2023-01-19

    Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia

    ✓ Peer-reviewed TREM2 and immune genetics Nature immunology

    Key finding: Heterozygous hypofunctional TREM2 variants impair microglia, accelerating late-onset Alzheimer's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2023-01-18

    TTR (transthyretin) leads the autophagy disaster relief team against TARDBP/TDP-43 proteinopathy

    ✓ Peer-reviewed Disease mechanisms Autophagy

    Key finding: Herein, we disclose that TTR upregulated in response to excessive TARDBP causes TARDBP aggregation in FTLD-TDP and co-accumulates with it. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →