Newest studies

Development of an Evidence-Based Cognitive Training Application for Elderly Individuals with Cognitive Dysfunction

57/100 ✓ Peer-reviewed Prevention trials Healthcare

Key finding: The application was developed with distinct user and administrator interfaces to support engagement and monitoring. +4 more findings

Full summary, score breakdown and related studies → Original source

Changes in the Parietal Lobe Subregion Volume at Various Stages of Alzheimer’s Disease and the Role in Cognitively Normal and Mild Cognitive Impairment Conversion

44/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Integrative Neuroscience

Key finding: The left inferior parietal lobule (IPL)_6_5 (rostroventral area 39) showed the best ability to discriminate between patients with AD and those with CN (AUC = 0.688). +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Blood Neurofilament Light Chain and Phospho-Tau 181 in Subjects with Mild Cognitive Impairment Due to Age-Related Hearing Loss

40/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Clinical Medicine

Key finding: Patients with hearing impairment presented slightly altered results on cognitive tests, typical of a mild cognitive impairment. +3 more findings

• Early Stage
• Biomarkers

Full summary, score breakdown and related studies → Original source

Distinct subcellular localization of tau and alpha-synuclein in lewy body disease

39/100 ✓ Peer-reviewed Lewy body dementia Acta Neuropathologica Communications

Key finding: The abundance of p-α-syn, p-tau, and MHCII was significantly associated with diagnosis of LBD. +2 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Explainable machine learning models for identifying mild cognitive impairment in older patients with chronic pain

55/100 ✓ Peer-reviewed Digital health tools BMC Nursing

Key finding: Age, education level, number of pain sites, pain duration, pain level, depression and sleep quality were risk factors of MCI in older patients with chronic pain. +4 more findings

• Digital Tools
• Early Stage

Full summary, score breakdown and related studies → Original source

Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospective observational study

43/100 ✓ Peer-reviewed Digital health tools Alzheimer s Research & Therapy

Key finding: Data from 262 records (260 unique participants) were analyzed. +4 more findings

• Digital Tools
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Global Burden of Alzheimer’s Disease and Other Dementias during 1990–2021: A Global Burden of Disease and Risk Factors Study 2021-Based Study

47/100 ✓ Peer-reviewed How common it is Neuroepidemiology

Key finding: The global age-standardized prevalence of AD and other dementias increased from 672 (95% uncertainty interval: 589 to 764) per 100,000 population in 1990 to 694 (603 to 794) per 100,000 population in 2021, with AAPCs of 0.09% (95% confidence interval: 0.06% to 0.11%). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Closing the gap in dementia research by community-based cohort studies in the Chinese population

47/100 ✓ Peer-reviewed Getting a diagnosis The Lancet Regional Health - Western Pacific

Key finding: China accounts for 1/5 of the global population and China faces a particularly heavy dementia burden due to its rapidly ageing population. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Lessons from the Implementation of the Sendai Framework for Disaster Risk Reduction from Latin America and the Caribbean

40/100 ✓ Peer-reviewed Prevention and risk International Journal of Disaster Risk Science

Key finding: Over the past decade, Latin America and the Caribbean (LAC) have made progress in implementing the Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR).

• Prevention

Full summary, score breakdown and related studies → Original source

Association of Polygenic Risk Score for 5 Diseases With Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition

60/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Among 463 ADNI participants with baseline MCI (mean age 72.6 ± 7.3 years, 43.4% female), the OSA PRS, adjusted for BMI, was significantly associated with MCI-to-AD progression. +4 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Clinical Practice Guidelines for Dementia: Recommendations for Cholinesterase Inhibitors and Memantine

50/100 ✓ Peer-reviewed Treatments Dementia and neurocognitive disorders

Key finding: Three main recommendations are presented: (1) For AD, cholinesterase inhibitors (donepezil, rivastigmine, galantamine) are strongly recommended for improving cognition and daily function based on moderate evidence; (2) Cholinesterase inhibitors are conditionally recommended for vascular dementia and Parkinson's disease dementia, with a strong recommendation for Lewy body dementia; (3) For moderate to severe AD, NMDA receptor antagonist (memantine) is strongly recommended, demonstrating significant cognitive and functional improvements. +4 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Mapping the effectiveness and risks of GLP-1 receptor agonists

62/100 ✓ Peer-reviewed Risk factors Nature medicine

Key finding: We used a discovery approach to systematically map an atlas of the associations of GLP-1RA use versus each comparator with 175 health outcomes. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Communicative intentions and liminal signs in interaction with people living with late-stage dementia

37/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Pragmatics

Key finding: Drawing on Goffman's distinction between "giving" and "giving off" information and Grice's theory of communicative intentions, we analyze interaction sequences where caregivers may or may not notice and respond to these signs. +4 more findings

Full summary, score breakdown and related studies → Original source

A mobile-based multidomain lifestyle intervention using Cognitive Evergreenland for older adults with subjective cognitive decline: a feasibility study

38/100 ✓ Peer-reviewed Mild cognitive impairment BMC Geriatrics

Key finding: The retention rate for MLIP-CE was 90.2% (37/41). +4 more findings

• Early Stage
• Diagnosis
• Lifestyle

Full summary, score breakdown and related studies → Original source

Estimation of Machine Learning–Based Models to Predict Dementia Risk in Patients With Atherosclerotic Cardiovascular Diseases: UK Biobank Study

46/100 ✓ Peer-reviewed Digital health tools JMIR Aging

Key finding: The findings of this study suggest that predictive modeling could inform patients and clinicians about ASCVD at risk for dementia. +2 more findings

• Risk Factors
• Digital Tools

Full summary, score breakdown and related studies → Original source

An interpretable machine learning tool for in-home monitoring of agitation episodes in people living with dementia: a proof-of-concept study

57/100 ✓ Peer-reviewed Digital health tools EClinicalMedicine

Key finding: Light Gradient-boosting Machine (LightGBM) achieved the highest performance in identifying agitation over an 8-day period with a sensitivity of 71.32% ± 7.38 and specificity of 75.28% ± 7.38. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

A European-Multicenter Network for the Implementation of Artificial Intelligence to Manage Complexity and Comorbidities of Atrial Fibrillation Patients: The ARISTOTELES Consortium

64/100 ✓ Peer-reviewed Digital health tools Thrombosis and Haemostasis

Key finding: In the prospective GLORIA-AF registry of AF patients, the presence of clinical complexity was associated with lower odds of being prescribed with OAC (odds ratio [OR] 0.50, 95% confidence interval [CI] 0.44–0.57), higher OAC discontinuation, and with a higher risk of adverse events (hazard ratio [HR] 1.63, 95% CI 1.43–1.86).[ 4 ] Indeed, “high clinical complexity” patients defined using latent class analysis constituted 6.6% of AF patients, and was associated with higher hazards of experiencing the primary composite outcome of all-cause death and major adverse cardiovascular events (HR 1.47, 95% 1.24–1.75).[ 5 ] Comorbidities and polypharmacy have an important influence on decision-making, by conditioning either lack of prescription of OAC in patients at risk or inappropriate dosing.[ 6 ] [ 7 ] [ 8 ] Recognizing that AF management is more than simply OAC alone, and requires a holistic and integrated care approach, contemporary guidelines globally on AF management have promoted this concept, based on the Atrial fibrillation Better Care (ABC) pathway, emphasizing Anticoagulation, Better symptom management with rate or rhythm control, and Comorbidity/lifestyle management.[ 9 ] [ 10 ] [ 11 ] The ABC pathway is well supported by clinical trial and real-world evidence,[ 11 ] whereby adherence to the ABC pathway is associated with a reduction in all-cause and cardiovascular mortality, stroke, and bleeding.[ 12 ] [ 13 ] Despite this, adherence to ABC-based management remains low, whereby a meta-analysis of 14 studies revealed that only 21% (95% CI 13–34%) of AF patients were managed in accordance with the ABC pathway.[ 12 ] This perhaps highlights a critical gap in the implementation of comprehensive evidence-based care strategies. +1 more finding

• Digital Tools
• Risk Factors

Full summary, score breakdown and related studies → Original source

Disparity in attitudes regarding assisted dying among physicians and the general public in Japan

36/100 ✓ Peer-reviewed Disparities BMC Medical Ethics

Key finding: The findings revealed that Japanese physicians did not display support for euthanasia (2%) and assisted suicide (1%); however, the general public supported euthanasia (33%) and assisted suicide (34%). +4 more findings

• Health Equity
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Comprehensive Review of Lipid Management in Chronic Kidney Disease and Hemodialysis Patients: Conventional Approaches, and Challenges for Cardiovascular Risk Reduction

41/100 ✓ Peer-reviewed Prevention and risk Journal of Clinical Medicine

Key finding: Statins show mixed results in CKD and ESRD, with limited benefits in reducing cardiovascular events in dialysis patients. +3 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Effects of the Mediterranean Diet on the Components of Metabolic Syndrome Concerning the Cardiometabolic Risk

49/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: It also helps regulate blood glucose levels, reducing the likelihood of developing type 2 diabetes. +4 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Middle-age cerebral small vessel disease and cognitive function in later life: a population-based prospective cohort study

57/100 ✓ Peer-reviewed Vascular contributions The Lancet Regional Health - Western Pacific

Key finding: Of the total, 908 (37.0%) participants had cSVD on MRI reading at baseline. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications

45/100 ✓ Peer-reviewed Inflammation and the immune system Molecular Neurodegeneration

Key finding: It has emerged as a significant player in various neurodegenerative diseases and brain disorders.

• Brain Biology
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Distinguishing Early from Late Mild Cognitive Impairment Using Magnetic Resonance Free-Water Diffusion Tensor Imaging

40/100 ✓ Peer-reviewed Mild cognitive impairment NeuroSci

Key finding: Significant MMSE differences were found between the CN and MCI groups, but not between EMCI and LMCI. +4 more findings

• Brain Scans
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

The possible role of cerebrolysin in the management of vascular dementia: Leveraging concepts

44/100 ✓ Peer-reviewed Lewy body dementia Neuroscience

Key finding: In conclusion, CBL could be effective therapeutic strategy in preventing and treating VD by targeting neuroinflammation, BBB injury, and chronic cerebral hypoperfusion.

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia

41/100 ✓ Peer-reviewed Risk factors Amino Acids

Key finding: Several differences in the concentration of amino acids were observed in AD patients compared to both healthy controls and VD patients. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source