Newest studies

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep

60/100 ✓ Peer-reviewed Laboratory science Cell

Key finding: We here employed an array of technologies and identified tightly synchronized oscillations in norepinephrine, cerebral blood volume, and cerebrospinal fluid (CSF) as the strongest predictors of glymphatic clearance during NREM sleep. +4 more findings

• Lifestyle

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Association of Metformin use with risk of dementia in patients with type 2 diabetes: A systematic review and meta-analysis

64/100 ✓ Peer-reviewed Prevention and risk Diabetes, Obesity and Metabolism

Key finding: Metformin might correlate with a lower dementia incidence in people with T2DM. +3 more findings

• Risk Factors

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Updated appropriate use criteria for amyloid and tau PET: A report from the Alzheimer's Association and Society for Nuclear Medicine and Molecular Imaging Workgroup

74/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & Dementia

Key finding: AUC for amyloid and tau PET provide expert recommendations for clinical use of these technologies in the evolving landscape of diagnostics and therapeutics for Alzheimer's disease. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Time to nursing home admission and death in people with dementia: systematic review and meta-analysis

73/100 ✓ Peer-reviewed How common it is BMJ

Key finding: The average life expectancy of people with dementia at time of diagnosis ranged from 5.7 years at age 65 to 2.2 at age 85 in men and from 8.0 to 4.5, respectively, in women. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

A Self-Reinforced "Microglia Energy Modulator" for Synergistic Amyloid-β Clearance in Alzheimer's Disease Model

43/100 ✓ Peer-reviewed Drug development Angewandte Chemie (International ed. in English)

Key finding: However, microglial metabolism is defective overall in AD, thereby undermining microglial phagocytic functions. +2 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model

48/100 ✓ Peer-reviewed Disease mechanisms Science Signaling

Key finding: After repeated, mild controlled blows, latently infected tissues showed reactivation of HSV-1; the production and accumulation of β amyloid and phosphorylated tau (which promotes synaptic dysfunction and neurodegeneration); and activated gliosis, which is associated with destructive neuroinflammation. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry

59/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s Research & Therapy

Key finding: (n = 16,683) had an average age of 69.07 ± 7.34, 72.04% were female, and had an average of 16.66 ± 2.26 years of education. +4 more findings

• Early Stage
• Digital Tools

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Barriers to self-management engagement among community-dwelling older adults with mild cognitive impairment: a qualitative study

38/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Psychiatry

Key finding: Twenty-six participants participated in the formal semi-structured interviews. +3 more findings

• Early Stage

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Dementia incidence among a cohort of lebanese older adults: first incidence estimates from the Middle East and North Africa region

55/100 ✓ Peer-reviewed How common it is Frontiers in Dementia

Key finding: After 3.5 years of follow up, 19 new cases of dementia were identified among 229 surviving participants. +4 more findings

• Risk Factors

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Retracted: Evaluating the Clinical Efficacy of an Exergame-Based Training Program for Enhancing Physical and Cognitive Functions in Older Adults With Mild Cognitive Impairment and Dementia Residing in Rural Long-Term Care Facilities: Randomized Controlled Trial

16/100 ⚠ Retracted — do not rely on it Disparities Journal of Medical Internet Research

Key finding: The “WarioWare: Move It!” intervention significantly improved physical flexibility, joint range of motion, motor coordination, hand dexterity, and cognitive function among older adults with mild cognitive impairment or dementia residing in rural LTCFs. +4 more findings

• Health Equity
• Clinical Trials
• Early Stage

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Climate Change and Health Within the Sendai Framework for Disaster Risk Reduction: Opportunities and Challenges

41/100 ✓ Peer-reviewed Prevention and risk International Journal of Disaster Risk Science

Key finding: The Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR) is at its 10th anniversary amidst a rapidly changing climate, which, together with social vulnerabilities, have led to significant impacts on human health and well-being.

• Prevention

Full summary, score breakdown and related studies → Original source

Impact of adherence to the Mediterranean diet on stroke risk

67/100 ✓ Peer-reviewed Prevention and risk GeroScience

Key finding: Our findings provide robust evidence supporting the protective effect of the Mediterranean diet against stroke. +4 more findings

• Lifestyle
• Prevention

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Anticorpos anti-amiloide no tratamento da Doença de Alzheimer: uma revisão narrativa

27/100 ✓ Peer-reviewed Treatments Revista Sociedade Científica

Key finding: Esta revisão examina as imunoterapias mais recentes direcionadas ao Aβ, com ênfase na eficácia de anticorpos monoclonais, como Aducanumab, Lecanemab e Donanemab. +4 more findings

• Treatments

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Limbic-predominant age-related TDP-43 encephalopathy in the oldest old: a population-based study

65/100 ✓ Peer-reviewed Laboratory science Brain

Key finding: Previous studies have shown that limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) increases with age, but there have been only a few studies, which have investigated this entity in a population-based setting. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications

34/100 ✓ Peer-reviewed Risk factors Small methods

Key finding: The central focus of this review is the application of ST in neuroscience, where it has significantly contributed to understanding the brain's complexity. +1 more finding

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Tract-specific white matter hyperintensities and neuropsychiatric syndromes: a multicentre memory clinic study

52/100 ✓ Peer-reviewed Vascular contributions Journal of Neurology Neurosurgery & Psychiatry

Key finding: Among 2935 patients (50.4% women; mean age=72.2 years; 19.8% subjective cognitive impairment, 39.8% mild cognitive impairment, and 40.4% dementia), larger WMH volume within projection fibres (B=0.24, SE=0.10, p=0.013) was associated with greater apathy. +4 more findings

• Care Services

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Identifying Challenges Related to the Management of Comorbidities in People with Dementia in Residential Care: Expert Delphi Consensus Exercise

36/100 ✓ Peer-reviewed Clinical safety Journal of Applied Gerontology

Key finding: We conducted a Delphi study comprising three rounds (two surveys and an interview) to identify the most difficult dementia comorbidities to deal with in residential care and related issues. +4 more findings

• Care Services

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Sarcopenia is a risk factor for postoperative delirium in geriatric hip fracture patients: a retrospective study

44/100 ✓ Peer-reviewed Clinical safety Frontiers in Medicine

Key finding: The incidences of POD and sarcopenia in geriatric hip fracture patients are high. +3 more findings

• Risk Factors

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Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflammation

36/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Pharmacology

Key finding: Modern clinical studies have demonstrated its significant therapeutic effects in treating Alzheimer’s disease (AD) without notable adverse reactions. +3 more findings

• Brain Biology

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Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer’s disease progression

38/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Cellular Neuroscience

Key finding: Accumulating evidence indicate that astrocytes are not homogeneous, but rather encompass heterogeneous subpopulations of cells that differ from each other in terms of transcriptomics, molecular signature, function and response in physiological and pathological conditions.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Virus-mediated delivery of single-chain antibody targeting TDP-43 protects against neuropathology, cognitive impairment and motor deficit caused by chronic cerebral hypoperfusion

35/100 ✓ Peer-reviewed Brain tissue and pathology Experimental Neurology

Key finding: In this model, the gradual deregulation of TDP-43 homeostasis in cortical neurons was associated with marked cognitive and motor deficits. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Daily-life walking speed, running duration and bedtime from wrist-worn sensors predict incident dementia: A watch walk – UK biobank study

60/100 ✓ Peer-reviewed Long-term cohort studies International Psychogeriatrics

Key finding: Median follow-up was 7.5 years (interquartile range: 7.0 to 9.0 years), during this time 387 participants (0.8 %) were diagnosed with dementia. +4 more findings

• Risk Factors
• Lifestyle
• Digital Tools

Full summary, score breakdown and related studies → Original source

Dissemination of the Care Ecosystem Collaborative Care Model for Dementia

48/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

Key finding: Implementation efforts resulted in the adoption of the Care Ecosystem at 28 health systems and eight community-based organizations, including 22 participants in Medicare's Guiding an Improved Dementia Experience (GUIDE) payment model. +4 more findings

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Positron emission tomography tracers for synucleinopathies

47/100 ✓ Peer-reviewed Disease mechanisms Molecular Neurodegeneration

Key finding: However, distinguishing between synucleinopathies and Parkinsonism with tauopathies poses a challenge, significantly impacting clinical drug development.

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Two-year follow-up of dementia caregivers after a digital health intervention WECARE: a mixed-method study

44/100 ✓ Peer-reviewed Digital health tools Aging & Mental Health

Key finding: Eighteen of 24 participants completed the survey and 15 participated in interviews. +4 more findings

• Digital Tools
• Caregiving

Full summary, score breakdown and related studies → Original source