Inflammatory Potential of the Diet and… | 2025

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58/100

✓ Peer-reviewed alzhub usefulness score 58 out of 100. Prevention and risk

Topic: Risk, prevention and care in population studies

We included 394,255 individuals including 184 incident cases of CD and 459 of UC after median follow-up of 13.6 years (4,889,910 person-years). High ISD scores were associated with a higher risk of CD (fourth vs. first quartile-adjusted HR: 1.88, 95% CI: 1.14-3.10; p-trend < 0.01) but not of UC (adjusted HR: 0.85, 95% CI: 0.63-1.15; p-trend 0.21). For CD, this association was mainly observed for women (adjusted HR: 2.14, 95% CI: 1.17-3.91; p-trend < 0.01). On subgroup analyses, those differences were mainly driven by low intakes of fibre, mono-unsaturated fatty acids, vitamin C, magnesium, onion and alcohol. A high ISD score is associated with a higher risk of developing CD but not UC. These results should be taken into account in high-risk populations.

Key findings

We included 394,255 individuals including 184 incident cases of CD and 459 of UC after median follow-up of 13.6 years (4,889,910 person-years).
High ISD scores were associated with a higher risk of CD (fourth vs. first quartile-adjusted HR: 1.88, 95% CI: 1.14-3.10; p-trend < 0.01) but not of UC (adjusted HR: 0.85, 95% CI: 0.63-1.15; p-trend 0.21).
For CD, this association was mainly observed for women (adjusted HR: 2.14, 95% CI: 1.17-3.91; p-trend < 0.01).
On subgroup analyses, those differences were mainly driven by low intakes of fibre, mono-unsaturated fatty acids, vitamin C, magnesium, onion and alcohol.
A high ISD score is associated with a higher risk of developing CD but not UC.

Why it matters

This cohort study found that a high inflammatory diet score was associated with higher risk of Crohn's disease but not ulcerative colitis. It provides no information on Alzheimer's disease.

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Study details

Participants394,255
Effect sizeHR: 1.88; HR: 0.85; HR: 2.14
Evidence strengthModerate

How this study scored 58/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alimentary Pharmacology & Therapeutics)
Journal's citation record	2 / 4	Alimentary Pharmacology & Therapeutics: journal h-index 246 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	4 / 4	394,255 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 17 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	5.7 citations a year over 3 year(s) since 2025
Impact for its field and year	4 / 6	Cited 9.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	2 / 4	Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Aurélien Amiot: h-index 43 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Oxford: institution h-index 2,205 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 28 institution(s) in 6 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39817326)
Free to read	2 / 2	Free to read
Total	58 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Meyer, A., Chan, S. S. M., Touvier, M., Julia, C., Tjønneland, A. M., Kyrø, C., et al. (2025). Inflammatory Potential of the Diet and Risk of Crohn's Disease and Ulcerative Colitis. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/apt.18497

Vancouver

Meyer A, Chan SSM, Touvier M, Julia C, Tjønneland AM, Kyrø C, et al. Inflammatory Potential of the Diet and Risk of Crohn's Disease and Ulcerative Colitis. Alimentary Pharmacology & Therapeutics. 2025. doi:10.1111/apt.18497. PMID: 39817326.

BibTeX

@article{meyer2025-39817326,
  author  = {Meyer, Antoine and Chan, Simon S. M. and Touvier, Mathilde and Julia, Chantal and Tjønneland, Anne Marie and Kyrø, Cecilie and Dahm, Christina Catherine and Katzke, Verena Andrea and others},
  title   = {{Inflammatory Potential of the Diet and Risk of Crohn's Disease and Ulcerative Colitis}},
  journal = {Alimentary Pharmacology \& Therapeutics},
  year    = {2025},
  doi     = {10.1111/apt.18497},
  pmid    = {39817326},
  url     = {https://doi.org/10.1111/apt.18497}
}

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