Newest studies

Mediterranean Diet and Lifestyle in Persons with Mild to Moderate Alzheimer's Disease

54/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Several studies have indicated that the Mediterranean diet (MedDiet) is associated with reduced incident cognitive decline and dementia, but few studies have been conducted in persons already diagnosed with Alzheimer's disease (AD). +3 more findings

• Lifestyle

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Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study

48/100 ✓ Peer-reviewed Risk factors Alzheimer's research & therapy

Key finding: Genetically determined CSHL was associated with an elevated risk of DLB (odds ratio [OR] 1.69; 95% CI 1.08 to 2.63; P = 0.021) and FTD (OR 1.66; 1.04 to 2.67; P = 0.035), but not AD (P = 0.958). +4 more findings

• Risk Factors

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Modifiable dementia risk factors associated with objective and subjective cognition

64/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Depression, socioeconomic status, hearing handicap, loneliness, education, smoking, tinnitus, little exercise, small social network, stroke, diabetes, and hypertension were all associated with impairments in at least one cognitive measure. +4 more findings

• Risk Factors

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[Alzheimer's dementia in people with Down syndrome : Results of guideline-assisted expert interviews on healthcare deficits in the diagnostics and treatment as well as solution approaches]

35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Zeitschrift fur Gerontologie und Geriatrie

Key finding: The identified deficits in the medical care of the target population and the approaches to solving them will be incorporated into the development of health policy recommendations in order to optimize the care situation of those affected in the long term. +1 more finding

• Down Syndrome
• Treatments

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GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

57/100 ✓ Peer-reviewed Genetics Nature genetics

Key finding: We identified eight independent significantly associated loci, of which four were new (COL4A1, PIK3R5, LZTS1 and APOC2). +2 more findings

• Genetics
• Brain Biology

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Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease

50/100 ✓ Peer-reviewed Tau biomarkers Molecular neurodegeneration

Key finding: Current AT(N) stratification for Alzheimer's disease (AD) accounts for complex combinations of amyloid (A), tau proteinopathy (T) and neurodegeneration (N) signatures. +3 more findings

• Biomarkers
• Brain Biology

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CSF complement proteins are elevated in prodromal to moderate Alzheimer's disease patients and are not altered by the anti-tau antibody semorinemab

50/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: All measured CSF complement proteins were increased in AD versus CU subjects, with C4a displaying the most robust increase. +4 more findings

• Biomarkers
• Early Stage

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Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting

61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A total of 337 participants were included: 136 ND, 77 PPD, and 124 Controls. +4 more findings

• Biomarkers

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Argentina-Alzheimer's Disease Neuroimaging Initiative: pioneering Alzheimer's Research in Latin America and its Implications for Regional Advancement

45/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These initiatives have contributed significantly to the development of regional research and serve as essential tools for health policy planning in Latin America. +1 more finding

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Brexpiprazole treatment for agitation in Alzheimer's dementia: A randomized study

61/100 ✓ Peer-reviewed Treatments Alzheimer's & Dementia

Key finding: Highlights Brexpiprazole treatment for 10 weeks improved agitation in Alzheimer's dementia. +1 more finding

• Treatments
• Clinical Trials

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Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review

86/100 ✓ Peer-reviewed Risk factors Ageing research reviews

Key finding: Vision impairment (VI) and eye diseases such as age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and cataract have been reported to be associated with cognitive impairment and dementia, however, to date, very little attempt has been made to collate and synthesizes such literature. +2 more findings

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Clinical and diagnostic implications of Alzheimer's disease copathology in Lewy body disease

46/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

Key finding: Evidence shows that LBD patients with AD copathology show an accelerated disease course, a greater risk of cognitive decline and an overall poorer prognosis. +3 more findings

• Diagnosis
• Brain Biology
• Biomarkers

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A novel peptide-based tau aggregation inhibitor as a potential therapeutic for Alzheimer's disease and other tauopathies

46/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Unlike other aggregation inhibitors, RI-AG03 effectively suppresses aggregation of multiple Tau species containing both hotspots in vitro and in vivo, is non-toxic, and suppresses aggregation-dependent neurodegenerative and behavioral phenotypes. +4 more findings

• Treatments
• Brain Biology

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Hyperspectral retinal imaging in Alzheimer's disease and age-related macular degeneration: a review

43/100 ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica communications

Key finding: Among various retinal imaging methods, hyperspectral imaging has garnered significant attention in this field.

• Brain Scans

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New tablet-based screening tool for assessment of cognitive decline in Nigeria

43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD

Key finding: We comment on the importance of the novel tablet-based screening tool for cognitive decline recently studied in Nigeria by Ogbuagu et al. +2 more findings

• Diagnosis

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Challenges in the practical implementation of blood biomarkers for Alzheimer's disease

45/100 ✓ Peer-reviewed Biomarkers The lancet. Healthy longevity

Key finding: Additionally, distinct scenarios present their own specific challenges. +4 more findings

• Biomarkers

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Mitochondrial dysfunction gene expression, DNA methylation, and inflammatory cytokines interaction activate Alzheimer's disease: a multi-omics Mendelian randomization study

57/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of translational medicine

Key finding: This study highlighted that the AD-causal MD genes could be regulated by epigenetic changes and interact with inflammatory cytokines, providing evidence for AD prevention and intervention. +2 more findings

• Genetics
• Brain Biology

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Interactive effect of diabetes mellitus and subclinical MRI markers of cerebrovascular disease on cognitive decline and incident dementia: a memory-clinic study

53/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

Key finding: Cognitive impairment is an increasingly recognized comorbidity of diabetes, yet the mechanisms underlying this association remain poorly understood. +3 more findings

• Risk Factors

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Tau proteotasis in Alzheimer's disease

43/100 ✓ Peer-reviewed Disease mechanisms Advances in protein chemistry and structural biology

Key finding: In the milieu of proteotoxicity, it would be significant for the cell to follow a specific path for Tau clearance. +2 more findings

• Brain Biology

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Inflammatory proteins associated with Alzheimer's disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial

79/100 ✓ Peer-reviewed Drug development Alzheimer's research & therapy

Key finding: EQW affected FCN2 (Cohen's d -0.019), PAI-1 (Cohen's d -0.033), sVCAM-1 (Cohen's d 0.035) and a cytokine-cytokine cluster (Cohen's d 0.037) significantly compared with placebo. +3 more findings

• Clinical Trials
• Brain Biology

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Detection of Alzheimer's Disease Using Hybrid Meta-ROI of MRI Structural Images

46/100 ✓ Peer-reviewed Brain scans and imaging Diagnostics (Basel, Switzerland)

Key finding: An AD diagnostic accuracy of 91.9% was achieved by using a hybrid meta-ROI consisting of thicknesses of entorhinal and middle temporal cortices, and the volumes of the hippocampus and inferior lateral ventricles. +2 more findings

• Brain Scans

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Multi-omics analysis reveals the key factors involved in the severity of the Alzheimer's disease

47/100 ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

Key finding: Next, we employed Artificial Intelligence (AI) based models to predict AD severity based on the significantly altered features identified in each omics analysis. +2 more findings

• Digital Tools

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Patterns of Migration Following Dementia Diagnosis

66/100 ✓ Peer-reviewed Costs and economics JAMA network open

Key finding: The sample included 1 626 127 Medicare beneficiaries (mean [SD] age, 80.1 [8.0] years; 922 194 women [56.7%]) who received diagnoses of the 4 conditions in 2016. +4 more findings

• Diagnosis

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Evaluating the updated LATE-NC staging criteria using data from NACC

57/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Of 1352 participants, 502 (37%) had LATE-NC (23% stage 1a, 6% stage 1b, 58% stage 2, 13% stage 3). +4 more findings

• Brain Biology

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Vascular cognitive impairment and dementia: Mechanisms, treatment, and future directions

43/100 ✓ Peer-reviewed Vascular contributions International journal of stroke : official journal of the International Stroke Society

Key finding: Moreover, cerebrovascular disease not only commonly co-occurs with Alzheimer's disease (AD) and increases the probability that AD pathology will result in clinical dementia, but may also contribute etiologically to the development of AD pathologies.

• Other Dementias
• Treatments
• Risk Factors

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