Newest studies

Population‐Based Norms for the Montreal Cognitive Assessment in Arab Adults

48/100 ✓ Peer-reviewed Getting a diagnosis Brain and Behavior

Key finding: Female gender, older age, and lower levels of education were associated with poorer overall test scores. +2 more findings

• Diagnosis

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Health benefits of leisure-time physical activity by socioeconomic status, lifestyle risk, and mental health: a multicohort study

58/100 ✓ Peer-reviewed Prevention and risk The Lancet Public Health

Key finding: 14 IPD-Work studies were assessed and six studies were excluded due to missing outcome data and unavailable data for pooling, resulting in the inclusion of eight studies with 124 909 participants. +4 more findings

• Lifestyle
• Health Equity

Full summary, score breakdown and related studies → Original source

Multi-Hazard Early Warning Systems in the Sendai Framework for Disaster Risk Reduction: Achievements, Gaps, and Future Directions

46/100 ✓ Peer-reviewed Prevention and risk International Journal of Disaster Risk Science

Key finding: Bringing together global efforts to enhance the implementation of warnings in managing vulnerabilities, hazards, risks, and disasters is essential to saving lives and for long-term vulnerability reduction. +1 more finding

• Prevention

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Higher level of [3H]UCB-J binding in ApoE Ɛ4 allele carriers with Alzheimer disease

35/100 ✓ Peer-reviewed Genetics Neuroscience Letters

Key finding: We report here that the reduction in SV2A binding is highly significant only in patients not carrying the ApoE ɛ4 allele.

• Genetics

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Mapping the Numbers of Dementia in Brazil: A Delphi Consensus Study

43/100 ✓ Peer-reviewed Risk factors International Journal of Geriatric Psychiatry

Key finding: Fifteen experts, with a mean professional experience of 25 ± 10 years, reached a consensus in the fourth round. +4 more findings

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Food security at risk: the consequences of limiting animal source foods

37/100 ✓ Peer-reviewed Risk factors Animal Frontiers

Key finding: We estimate that up to three million more Americans will be made food insecure by the taxes alone, which amounts to almost a 10% increase in overall food insecurity rates. +4 more findings

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Eating and swallowing care disparities in persons with dementia: A conceptual framework

41/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Our framework highlights individual-, system-, and community-level factors and resources influencing person-centered eating and swallowing care for PLWD. +4 more findings

• Health Equity

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Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy

53/100 ✓ Peer-reviewed Prevention and risk Protein & cell

Key finding: This condition casts a significant shadow on global health due to its complex and multifactorial nature.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma p-tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10-year window

70/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: Plasma p-tau217 is a prognostic marker for identifying individuals who will develop cognitive impairment within ten years. +1 more finding

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses

66/100 ✓ Peer-reviewed Genetics Alzheimer's & Dementia

Key finding: We provide evidence for 16 novel AD loci and advocate for more studies using whole genome sequencing-based GWAS of diverse cohorts. +3 more findings

• Genetics

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Effect of epigallocatechin-3-gallate (EGCG) on cognitive functioning and the expression of APP and BDNF in the hippocampus of rats with streptozotocin -induced Alzheimer-like disease

37/100 ✓ Peer-reviewed Risk genes beyond APOE Biochemistry and Biophysics Reports

Key finding: STZ also impaired the memory function (P < 0.05) and a dose of 25 mg/kg EGCG could significantly return it to the control level (29 % vs 53 %, P < 0.01). +3 more findings

• Digital Tools

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The effect of Lewy body (co-)pathology on the clinical and imaging phenotype of amnestic patients

65/100 ✓ Peer-reviewed Lewy body dementia Brain

Key finding: Based on positive/negative results on the different biomarkers, subjects were classified as 'AD-LB-' (n = 304), 'AD+LB-' (n = 335), 'AD+LB+' (n = 158) and 'AD-LB+' (n = 68). +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research

47/100 ✓ Peer-reviewed Treatments The Journal of Prevention of Alzheimer s Disease

Key finding: Our review of the trial publications found high quality evidence of statistically significant group differences, but also recognized that there are mixed views on the clinical relevance of the observed differences and the value of therapy for individual patients.

• Treatments
• Side Effects

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Association of Plasma Biomarkers of Alzheimer Disease and Neurodegeneration With Longitudinal Intra-Network Functional Brain Connectivity

61/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: = 0.02, 95% CI -0.07 to -0.01) network connectivity. +4 more findings

• Biomarkers

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Biomarker treatment effects in two phase 3 trials of gantenerumab

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Gantenerumab reduced amyloid PET load, CSF biomarkers of amyloid beta (Aβ)40, total tau (t-tau), phosphorylated tau 181 (p-tau181), neurogranin, S100 calcium-binding protein B (S100B), neurofilament light (NfL), alpha-synuclein (α-syn), neuronal pentraxin-2 (NPTX2), and plasma biomarkers of t-tau, p-tau181, p-tau217, and glial fibrillary acidic protein (GFAP) while increasing plasma Aβ40, Aβ42. vMRI showed increased reduction in whole brain volume and increased ventricular expansion, while hippocampal volume was unaffected. +4 more findings

• Biomarkers
• Clinical Trials
• Treatments

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Plasma p-tau217 and p-tau217/Aβ1-42 are effective biomarkers for identifying CSF- and PET imaging-diagnosed Alzheimer's disease: Insights for research and clinical practice

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma p-tau217 and p-tau217/Aβ1-42 are effective diagnostic tools. +3 more findings

• Biomarkers
• Brain Scans
• Treatments

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Group and partnered dance for people living with dementia: an overview of intervention design and measurement considerations

58/100 ✓ Peer-reviewed Clinical safety Frontiers in Psychology

Key finding: PLWD also commonly experience social isolation (Shen et al., 2022), poorer physical function (Jehu et al., 2024a), worsened behavioral and psychological symptoms (Cerejeira et al., 2012), poorer quality of life (Cerejeira et al., 2012), and reduced access to healthcare (Mitchell et al., 2016) compared to older adults without dementia. +4 more findings

• Clinical Trials

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The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke

41/100 ✓ Peer-reviewed Disease mechanisms Brain Research Bulletin

Key finding: The advanced glycation end-products (AGEs) are toxic molecules result from non-enzymatic interactions of sugar with lipids or proteins.

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UK Biobank MRI data can power the development of generalizable brain clocks: A study of standard ML/DL methodologies and performance analysis on external databases

41/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage

Key finding: In this study, we present a comprehensive pipeline to train and compare a broad spectrum of machine learning and deep learning brain clocks, integrating diverse preprocessing strategies and correction terms.

• Brain Scans

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Plasma Biomarkers in the Distinction of Alzheimer’s Disease and Frontotemporal Dementia

46/100 ✓ Peer-reviewed Lewy body dementia International Journal of Molecular Sciences

Key finding: Patients with AD had lower Aß42/40 ratios and NfL levels, along with higher levels of p-tau181 and GFAP, compared with FTD patients.

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Lewy body diseases and the gut

43/100 ✓ Peer-reviewed Lewy body dementia Molecular Neurodegeneration

Key finding: We predict that a better understanding of how pathophysiologies in the gut influence disease risk and progression will accelerate discoveries that will lead to a deeper overall mechanistic understanding of disease and potential therapeutic strategies targeting the gut-brain axis to delay, arrest, or prevent disease progression.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Moving beyond the prevalent exposure design for causal inference in dementia research

61/100 ✓ Peer-reviewed How common it is The Lancet Healthy Longevity

Key finding: Through a systematic search, we found that 84 (72%) of the 116 latest observational cohort studies that investigated factors hypothesised to reduce the risk of dementia (hearing aids, physical activity, antihypertensives, antidiabetics, and antidepressants) used a prevalent exposure design.

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The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia

49/100 ✓ Peer-reviewed How common it is Experimental Gerontology

Key finding: In older subjects without dementia, we showed that markers of inflammaging were differently associated with chronological age than with frailty. +2 more findings

• Brain Biology

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Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection

65/100 ✓ Peer-reviewed Long-term cohort studies Nature medicine

Key finding: Whether this holds true for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infections is unknown. +3 more findings

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Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review

53/100 ✓ Peer-reviewed Disease mechanisms Frontiers in dementia

Key finding: This systematic review aims to elucidate the neuropathological basis of the HIDA and psychosis domains, exploring whether distinct proteinopathies and neural circuit dysfunctions are associated with these symptoms. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source