Newest studies

Reference proteins to improve Core 1 and Core 2 Alzheimer’s disease CSF and plasma biomarkers

63/100 ✓ Peer-reviewed Biomarkers Brain

Key finding: Using the Swedish BioFINDER-2 cohort [n = 1702, 50.7% male, mean (standard deviation) age 68.4 (12.2) years], we compared the associations between tau/Aβ-PET load and fluid biomarkers alone versus biomarkers in a ratio with a reference protein (Aβ40 or np-tau) in univariate linear regression models. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Processed meat in the diet: general nutritional profile–protein quality and micronutrients

36/100 ✓ Peer-reviewed Risk factors Animal Frontiers

Key finding: Processed meats are a significant source of proteins, indispensable amino acids (IAA), A and B vitamins, zinc, phosphorus, iron, and several micronutrients (Table 1).

• Lifestyle

Full summary, score breakdown and related studies → Original source

Real-world experience with lecanemab therapy for Alzheimer’s disease in the Intermountain West

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: Our study examined the safety and tolerability of centralized lecanemab administration across a widely distributed region and suggests that use of distributed infusion sites increases access to disease-modifying treatment without significant increase in risk. +1 more finding

• Treatments
• Side Effects

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Diffusion tensor imaging analysis of aged dogs with and without canine cognitive dysfunction

45/100 ✓ Peer-reviewed Brain scans and imaging BMC veterinary research

Key finding: DTI revealed significant differences in white matter diffusivity between CCD and cognitively healthy aged dogs. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

AI-Based Severity Classification of Dementia Using Gait Analysis

44/100 ✓ Peer-reviewed Digital health tools Sensors

Key finding: Our findings highlight the promise of AI-based tools in advancing our understanding of gait characteristics in dementia and supporting the development of more accurate diagnostic models for complex or large datasets.

• Digital Tools

Full summary, score breakdown and related studies → Original source

Are Deep White Matter Hyperintensities Associated with Amyloid-Related Imaging Abnormalities in Patients with Alzheimer Disease Treated with Lecanemab?

56/100 ✓ Peer-reviewed Treatments American Journal of Neuroradiology

Key finding: ARIA-positive patients had significantly higher Fazekas scores compared with ARIA-negative patients (1.37 versus 1.0; P = .0262), indicating a greater DWMH burden. +4 more findings

• Treatments
• Brain Scans
• Side Effects

Full summary, score breakdown and related studies → Original source

Direct evidence for dendritic spine compensation and regeneration in Alzheimer's disease models

46/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We discovered that dendritic spine elimination-induced either artificially or in Aβ models-triggers a two-stage compensatory response: rapid enlargement of remaining spines followed by delayed spine regeneration. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

The microbiota-gut-brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention

43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in aging neuroscience

Key finding: Despite disorder-specific variations, shared microbial and immunological mechanisms emerge across the spectrum of conditions. +4 more findings

• Brain Biology
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Validation of a MIND diet screener in older adults

46/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: MIND diet scores from the screener showed strong positive correlation (r = 0.71, ρ = 0.70, p < 0.001) and comparable ranking ability (63% correctly classified, 1% grossly misclassified, kw = 0.67) compared to those from the FFQ, as well as significant associations with nutrient profiles. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease

52/100 ✓ Peer-reviewed Genetics Molecular neurodegeneration

Key finding: Transcriptomics and polygenic risk analysis position resilience as an intermediate AD state. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Alzheimer's disease-associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell-derived microglia-like cells

46/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Protective PLCG2P522R microglia showed significant transcriptomic similarity to isogenic controls. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Contactless longitudinal monitoring in the home characterizes aging and Alzheimer's disease-related night-time behavior and physiology

75/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: AD was characterized by longer time in bed, more bed exits, less snoring, and changes in estimated sleep states. +4 more findings

Full summary, score breakdown and related studies → Original source

Multivariate models using NULISAseq and plasma p-tau217 for staging Alzheimer's disease

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Using a panel of biomarkers was significantly better at predicting disease stage compared with p-tau217 alone; however, the difference was dependent upon p-tau217 assay. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Predicting cognitive decline with amyloid-PET, plasma p-tau217, Aβ42/40, and p-tau217/Aβ42 in a community-based cohort - relevance for clinical trial enrollment

59/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In the CU, using combined plasma Aβ42/40 and p-tau217 cut-offs for eligibility yielded the lowest sample size estimates for a comprehensive multidomain cognitive composite score, whereas sample sizes were higher for all other inclusion criteria based on single biomarkers. +4 more findings

• Biomarkers
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome

54/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Higher baseline WMH volume and higher GFAP were associated with a greater likelihood of diagnostic progression. +4 more findings

• Biomarkers
• Diagnosis
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Body mass index and blood volume influence plasma biomarkers and positron emission tomography classification in preclinical Alzheimer's disease

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Elevated BMI/BV associated with lower BBM concentrations, especially for p-Tau217 and NfL, independent of brain amyloid burden. +4 more findings

• Biomarkers
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Combining plasma neurofilament light chain and frontotemporal atrophy improves differentiation of bvFTD from primary psychiatric disorders

59/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Both atrophy (AUC = 0.87, 95% confidence interval [95% CI: 0.79 to 0.94]) and NfL (AUC = 0.89, 95% CI: 0.81 to 0.96) showed significant predictive ability, which improved when combined (AUC = 0.93, 95% CI: 0.87 to 0.99). +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Evidence-based standardized sample handling protocol for accurate blood-based Alzheimer's disease biomarker measurement: Results and consensus of the Global Biomarker Standardization Consortium

54/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: All assessed BBM levels varied by over 10% by collection tube type. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Combining plasma p-tau231 and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In single predictor models, p-tau231 (AUC = 0.87, p = 0.005) and GFAP (AUC = 0.87, p = 0.01) were associated with amyloid positivity, and p-tau231 remained significant in all multi-predictor models (p-values < 0.02). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Predicting severity of cerebral amyloid angiopathy neuropathology: A modeling approach using NACC and ROSMAP data

52/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: CAARS has the potential to predict CAA severity; however, its clinical utility should be evaluated in follow-up studies. +2 more findings

• Treatments
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Safety, tolerability, immunogenicity, and efficacy of ABvac40 active immunotherapy against Aβ40 in patients with mild cognitive impairment or very mild Alzheimer's disease: A randomized, double-blind, placebo-controlled phase 2 study

89/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These findings support further investigation of ABvac40 as a potential disease-modifying therapy. +2 more findings

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Lecanemab treatment for Alzheimer's Disease of varying severities and associated plasma biomarkers monitoring: A multi-center real-world study in China

74/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These findings support the short-term efficacy and safety of Lecanemab in early AD and highlight plasma biomarkers as a treatment-responsive biomarker. +2 more findings

• Treatments
• Biomarkers
• Side Effects

Full summary, score breakdown and related studies → Original source

Chronic rhinosinusitis and cognition: a systematic review and meta-analysis

57/100 ✓ Peer-reviewed Inflammation and the immune system Rhinology

Key finding: CRS is associated with 9% poorer global cognitive function, while CRS treatment is associated with 8-9% improvements in processing speed and working memory. +4 more findings

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MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk

43/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia

Key finding: Lower DTI-ALPS, lower BOLD-CSF coupling, and higher CP volume predicted dementia, but PVS volume did not. +4 more findings

• Risk Factors
• Brain Scans
• Biomarkers

Full summary, score breakdown and related studies → Original source

Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase‐derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance

36/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia

Key finding: With elevated HbA1c, greater LA-derived diol/epoxide ratios were associated with greater WMH volume (β [95% CI] = 0.565 [0.100, 1.030], p = 0.017), lower global BPF (β [95% CI] = -0.476 [-0.903, -0.048], p = 0.029), and poorer memory performance (β [95% CI] = -0.603 [-1.070, -0.136], p = 0.012), such that detrimental associations were observed only in T2DM. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source