Newest studies

The effect of apathy on quality of life and caregiver burden in patients with dementia

61/100 ✓ Peer-reviewed Caregiving Cognitive neuropsychiatry

Key finding: The mean age of the patients was 73.1 ± 11.7, and the time since diagnosis was 3.9 ± 3.1 years; 64.8% had Alzheimer's type dementia, and 53.4% (n = 47) had mild dementia. +4 more findings

• Caregiving

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Multi-Targeting Phytochemicals for Alzheimer's Disease

43/100 ✓ Peer-reviewed Treatments Phytotherapy research : PTR

Key finding: It could be concluded that phytochemicals light serve as an effective therapy for AD.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

"Did I buy that just now?" – Investigating factors influencing the accuracy of food choice self-reports in a simulated online grocery store

34/100 ✓ Peer-reviewed Risk factors Not indexed

Key finding: Reporting accuracy significantly increased to 78 % with image-based memory aids for specific product categories (e.g., apples), and to 89 % with text-based memory aids for general categories (e.g., vegetables). +1 more finding

• Digital Tools

Full summary, score breakdown and related studies → Original source

"Did I buy that just now?" – Investigating factors influencing the accuracy of food choice self-reports in a simulated online grocery store

44/100 ✓ Peer-reviewed Risk factors Not indexed

Key finding: Reporting accuracy significantly increased to 78 % with image-based memory aids for specific product categories (e.g., apples), and to 89 % with text-based memory aids for general categories (e.g., vegetables). +1 more finding

• Digital Tools

Full summary, score breakdown and related studies → Original source

Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies

38/100 ✓ Peer-reviewed Disease mechanisms Biomolecules

Key finding: Recently, some studies indicated a potential benefit of drugs acting on the adrenergic receptors for AD and dementias, although due to the heterogeneity of the drug classes used, the results on the whole remain inconclusive.

• Treatments

Full summary, score breakdown and related studies → Original source

Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy

46/100 ✓ Peer-reviewed Inflammation and the immune system Science Translational Medicine

Key finding: These results support the translation of Xe inhalation as an approach for treating AD.

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Dysphagia in older adults with mild cognitive impairment and dementia through fluoroscopic study with barium swallow in a memory clinic

51/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in Neurology

Key finding: Our findings highlight the altered phases of swallowing in patients with dementia. +3 more findings

• Early Stage
• Care Services

Full summary, score breakdown and related studies → Original source

The Validity and Reliability of the Turkish Version of the Rowland Universal Dementia Assessment Scale (RUDAS) for Alzheimer’s Disease and Mild Cognitive Impairment

33/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Drug Delivery and Therapeutics

Key finding: The Cronbach alpha coefficient of the RUDAS scale is 0.8529. +4 more findings

• Early Stage

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The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease

42/100 ✓ Peer-reviewed Risk genes beyond APOE Autophagy

Key finding: Loss of CANX results in the inactivity of ULK1 kinase and inhibits autophagy flux. +1 more finding

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Lateralization of the Aberrant Amplitude of Low-Frequency Fluctuation within the Default Mode Network in Patients with Mild Cognitive Impairment

38/100 ✓ Peer-reviewed Mild cognitive impairment Academic Radiology

Key finding: The DMN is the highest coverage of brain network regarding changes in local brain activity in patients with MCI. +3 more findings

• Early Stage

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The Effect of Life Activity Levels of Palliative Care Patients on the Caregivers’ Perception of Caregivers Burden

41/100 ✓ Peer-reviewed Caregiving Journal of Palliative Care

Key finding: The average age for patient was 78.13 ± 10.25 and for caregivers was 54.64 ± 13.22 years. +4 more findings

• Caregiving

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The global research of magnetic resonance imaging in Alzheimer’s disease: a bibliometric analysis from 2004 to 2023

47/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in Neurology

Key finding: A total of 13,659 articles were obtained in this study. +4 more findings

• Brain Scans

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Amygdala Nuclei Atrophy in Cognitive Impairment and Dementia: Insights from High-Resolution Magnetic Resonance Imaging

42/100 ✓ Peer-reviewed Getting a diagnosis Medicina

Key finding: Significant amygdala atrophy was observed in multiple amygdala nuclei across cognitive performance groups, with more pronounced changes in the low-performance group. +3 more findings

• Brain Scans

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Biofluid biomarkers in distinguishing young-onset dementia from primary psychiatric disorders

42/100 ✓ Peer-reviewed Getting a diagnosis Current Opinion in Psychiatry

Key finding: There has been growing interest in the role of biofluid biomarkers to aid the diagnosis of dementia in older people.

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Mortality and Function After Hip Fracture or Pneumonia in People With and Without Dementia

44/100 ✓ Peer-reviewed Getting a diagnosis Journal of the American Geriatrics Society

Key finding: Among people with dementia, predicted 1-year mortality was higher among those with hip fracture (35.4%) versus those without hip fracture (14.8%), with similar patterns for pneumonia (49.6% vs. 13.0%). +4 more findings

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Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age

61/100 ✓ Peer-reviewed Prevention and risk New England Journal of Medicine

Key finding: Of 1054 women with a mean age of 56.0 years at baseline, 1003 (95.2%) completed 10 years of follow-up. +4 more findings

• Prevention
• Clinical Trials

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Associations of modifiable dementia risk factors with dementia and cognitive decline: evidence from three prospective cohorts

59/100 ✓ Peer-reviewed Prevention and risk Frontiers in Public Health

Key finding: Among the 11 risk factors, educational attainment has the greatest impact on dementia risk and cognitive decline. +4 more findings

• Risk Factors
• Prevention

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Association between air pollution and lifestyle with the risk of developing mild cognitive impairment and dementia in individuals with cardiometabolic diseases

46/100 ✓ Peer-reviewed Prevention and risk Scientific Reports

Key finding: There appears to be a statistically significant association between high levels of ambient air pollution, unhealthy lifestyles, and a higher risk of developing mild cognitive impairment and dementia in the CMDs population.

• Risk Factors
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Mediterranean diet and dementia: MRI marker evidence from meta-analysis

64/100 ✓ Peer-reviewed Prevention and risk European journal of medical research

Key finding: A total of 20 relevant studies involving 44,893 individuals were included in the analysis. +4 more findings

• Brain Scans
• Lifestyle

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Long-Term Intake of Red Meat in Relation to Dementia Risk and Cognitive Function in US Adults

66/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: Replacing 1 serving per day of nuts and legumes for processed red meat was associated with a 19% lower risk of dementia (HR 0.81, 95% CI 0.75-0.86), 1.37 fewer years of cognitive aging (95% CI -2.49 to -0.25), and a 21% lower risk of SCD (RR 0.79, 95% CI 0.68-0.92). +3 more findings

• Risk Factors

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Estimating the burden of underdiagnosis within England: A modelling study of linked primary care data

42/100 ✓ Peer-reviewed Risk factors PLoS ONE

Key finding: Levels of underdiagnosis varied between 16% for stroke and 69% for prostate cancer in 2018. +4 more findings

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Dementia Diagnosis Unawareness and Caregiver Burden in a Multi-ethnic Cohort

70/100 ✓ Peer-reviewed Caregiving Journal of general internal medicine

Key finding: Eighty-one percent of eligible participants were not aware of a dementia diagnosis. +4 more findings

• Caregiving
• Diagnosis
• Health Equity

Full summary, score breakdown and related studies → Original source

Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy

68/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course.

• Brain Biology

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The immunology of stroke and dementia

43/100 ✓ Peer-reviewed Treatments Immunity

Key finding: Ischemic stroke and vascular cognitive impairment, caused by a sudden arterial occlusion or more subtle but protracted vascular insufficiency, respectively, are leading causes of morbidity and mortality worldwide with limited therapeutic options. +3 more findings

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Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities

45/100 ✓ Peer-reviewed Disease mechanisms Communications Biology

Key finding: Our results indicate that the aBDTOs possess different structural and morphological features that impact neuronal function, gene regulation, and ultimately disease progression. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source