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Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT
David M. Reboussin, Sarah A. Gaussoin, Nicholas M. Pajewski, Byron C. Jaeger, Bonnie C. Sachs, Stephen R. Rapp, Mark A. Supiano, Maryjo L. Cleveland et al.. Neurology, 2025-01-16
Topic: Risk, prevention and care in population studies
Of 9,361 randomized participants, 7,221 (77%) were eligible to be re-contacted. Cognitive status of 4,232 (59%) was ascertained (mean age 67 years, 36% female). We accrued a total of 216 new cases of probable dementia, less than our target of 326. Over a median follow-up of 7 years, 248 participants of the intensive treatment group (8.5 per 1,000 person-years) were adjudicated with probable dementia, compared with 293 participants (10.2 per 1,000 person-years) in the standard treatment group (hazard ratio [HR], 0.86; 95% CI, 0.72-1.02). Consistent with earlier results from the trial, the rate of both mild cognitive impairment (MCI; HR, 0.87 95% CI, 0.76-1.00) and a composite of MCI or probable dementia was lower with intensive treatment (HR, 0.89; 95% CI, 0.79, 0.99). Among ambulatory adults with hypertension and high cardiovascular risk, intensive treatment vs standard treatment of SBP for 3.3 years resulted in a lower risk of MCI and cognitive impairment including MCI or probable dementia, but not for probable dementia alone. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that intensively reducing SBP (target <120 mm Hg) decreases the risk of cognitive impairment in individuals aged 50 years and older with hypertension. CLINICAL TRIAL INFORMATION: Clinical trial number NCT01206062.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Reboussin, D. M., Gaussoin, S. A., Pajewski, N. M., Jaeger, B. C., Sachs, B. C., Rapp, S. R., et al. (2025). Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT. Neurology. https://doi.org/10.1212/wnl.0000000000213334
Vancouver
Reboussin DM, Gaussoin SA, Pajewski NM, Jaeger BC, Sachs BC, Rapp SR, et al. Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT. Neurology. 2025. doi:10.1212/wnl.0000000000213334. PMID: 39819096.
BibTeX
@article{reboussin2025-39819096,
author = {Reboussin, David M. and Gaussoin, Sarah A. and Pajewski, Nicholas M. and Jaeger, Byron C. and Sachs, Bonnie C. and Rapp, Stephen R. and Supiano, Mark A. and Cleveland, Maryjo L. and others},
title = {{Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT}},
journal = {Neurology},
year = {2025},
doi = {10.1212/wnl.0000000000213334},
pmid = {39819096},
url = {https://doi.org/10.1212/wnl.0000000000213334}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Of 9,361 randomized participants, 7,221 (77%) were eligible to be re-contacted.
- Cognitive status of 4,232 (59%) was ascertained (mean age 67 years, 36% female).
- We accrued a total of 216 new cases of probable dementia, less than our target of 326.
- Over a median follow-up of 7 years, 248 participants of the intensive treatment group (8.5 per 1,000 person-years) were adjudicated with probable dementia, compared with 293 participants (10.2 per 1,000 person-years) in the standard treatment group (hazard ratio [HR], 0.86; 95% CI, 0.72-1.02).
- Consistent with earlier results from the trial, the rate of both mild cognitive impairment (MCI; HR, 0.87 95% CI, 0.76-1.00) and a composite of MCI or probable dementia was lower with intensive treatment (HR, 0.89; 95% CI, 0.79, 0.99).
Why it matters
Intensively lowering systolic blood pressure below 120 reduced the combined outcome of mild cognitive impairment or probable dementia, but the reduction in probable dementia alone was not statistically significant. This suggests tighter blood pressure control may help prevent milder thinking problems in people with hypertension, though it did not clearly prevent dementia by itself.
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Study details
- Participants248
- Effect sizeor 3.3
- Evidence strengthHigh
How this study scored 62/100
Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 248 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 24 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 15.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Jeff D. Williamson: h-index 101 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Utah: institution h-index 1,238 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39819096) |
| Free to read | 2 / 2 | Free to read |
| Total | 62 / 100 | — |
What each of these 20 components measures, and what this score is not →
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