Newest studies

Plasma p-Tau217 and p-Tau181 levels in Well-Controlled versus Drug-Resistant focal epilepsy

54/100 ✓ Peer-reviewed Biomarkers Epilepsy & behavior : E&B

Key finding: Plasma was collected from 103 patients: 48 well-controlled (C, 31.3 % female) and 55 drug-resistant (DR, 50.9 % female). +4 more findings

• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

Synergistic impacts of physical activity and sleep on risk of dementia and all-cause mortality in Chinese older stroke survivors

43/100 ✓ Peer-reviewed Vascular contributions Journal of Stroke and Cerebrovascular Diseases

Key finding: Older stroke survivors engaging in regular PA had a 38 % reduced risk of dementia [Odds Ratio (OR) =0.62, 95 % Confidence Interval (CI): 0.56-0.69, P < 0.001] and a 44 % lower risk of mortality [Hazard Ratio (HR) =0.56, 95 % CI: 0.52-0.59, P < 0.001]. +4 more findings

• Lifestyle
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation

37/100 ✓ Peer-reviewed Risk genes beyond APOE Autophagy

Key finding: : ACTB: actin, beta; AD: Alzheimer disease; ADAM10: a disintegrin and metallopeptidase domain 10; ADGGA: acyl diacylglyceryl glucuronide; AHexSIS: acylhexosyl sitosterol; AHexSTS: acylhexosyl stigmasterol; AIF1/IBA1: allograft inflammatory factor 1; APP: amyloid beta precursor protein; ATG5: autopha

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Radionuclide Selection Influences Imaging Outcomes in Immuno-PET with a Brain-Penetrating Anti–Amyloid-β Antibody

32/100 ✓ Peer-reviewed Treatments Journal of Nuclear Medicine

Key finding: PET imaging demonstrated high cortical brain uptake of all 3 radiotracers in Tg-ArcSwe mice. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Deep neural networks and genome-wide associations reveal the polygenic architecture of local brain aging

37/100 ✓ Peer-reviewed Risk factors GeroScience

Key finding: We identified 1,212 single-nucleotide polymorphisms (SNPs) significantly associated with LBA in at least one brain region. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

REMINDER program: a randomized controlled trial protocol of a neuropsychological intervention for lifestyle modification in older adults at risk of dementia

43/100 ✓ Peer-reviewed Cognitive tests and assessment BMC Geriatrics

Key finding: The REMINDER program contributes to dementia prevention research by combining cognitive, lifestyle, and psychosocial strategies within a group-based format, aiming to foster long-term adherence to brain-protective behaviors. +3 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Unveiling Alzheimer's disease (1901-2025): Historical insights, global burden, biological mechanisms, diagnostics, and therapeutic strategies

42/100 ✓ Peer-reviewed Drug development Ageing research reviews

Key finding: Alois Alzheimer in 1906, has evolved from a rare presenile dementia to a global health crisis affecting over 58 million people as of 2020, with projections reaching 152 million by 2050. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Plasma P-tau217, GFAP, and NfL as biomarkers for Alzheimer's disease: role in disease stratification, pathological progression, and cognitive decline

68/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: 1,275 participants; amyloid PET, tau PET (n=584), and blood biomarkers all measured +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Accelerometry-Measured Physical Activity Predicts Dementia Onset in a National Cohort of Older Adults

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment medRxiv

Key finding: Over one year of follow-up, higher physical activity levels were associated with lower risk of incident dementia (OR = 0.66, 95% CI [0.55 - 0.79]), even after adjusting for age, gender, and comorbidities (OR = 0.68, 95% CI [0.57 - 0.82]). +2 more findings

• Risk Factors
• Prevention
• Lifestyle

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Consensus-Harmonized Neuropsychological Assessment for Vascular Cognitive Impairment and Dementia

51/100 ✓ Peer-reviewed Vascular contributions JAMA Network Open

Key finding: A total of 44 experts participated in 3 survey rounds, with 28 to 31 participants each. +4 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

The Role of GFAP as a Marker of Astrocyte Activation in the Pathogenesis of Alzheimer's Dementia: A Literature Review

28/100 ✓ Peer-reviewed Inflammation and the immune system Health & Medical Sciences

Key finding: The study results show that GFAP plays a crucial role as a sensitive biomarker for astrocyte activation that occurs since the preclinical phase of Alzheimer's, demonstrating a strong correlation with amyloid-beta accumulation and the neuroinflammatory process. +2 more findings

• Brain Biology
• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia

43/100 ✓ Peer-reviewed Getting a diagnosis Parkinsonism & Related Disorders

Key finding: We identified 51 transcriptome-wide significant (edgeR q < 0.05) DEGs, compared to controls, and 26 transcriptome-wide significant DEGs, compared to PD, in PDD plasma SEV. +4 more findings

• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Evaluating Plasma p-tau217 as an Endpoint for Alzheimer Disease Clinical Trials

68/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: A total of 716 individuals were included in the analysis: 413 cognitively unimpaired (CU) participants (58.6% female; mean age = 70.6 years, SD = 7.9) and 303 cognitively impaired (CI) participants (54.7% female; mean age = 73.2 years, SD = 7.4). +4 more findings

• Biomarkers
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Projected extreme temperature event-attributable dementia deaths in China: a climate–ageing–adaptation framework

48/100 ✓ Peer-reviewed Risk factors EBioMedicine

Key finding: Without adaptation, ADD heatwave-attributable deaths are projected to rise sharply, especially under rapid socioeconomic development with high greenhouse gas emissions scenario (SSP5-RCP8.5) in the 2080s, which reach 59,088-an 11-fold (+1003%) increase comparing to 2010s levels. +4 more findings

Full summary, score breakdown and related studies → Original source

Conformation-based detection of tau seeds with a novel VHH

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: When used to stain mouse and human brain tissues, VHH(510M) revealed pathological tau accumulation that was often independent of AT8-positive lesions.

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Plasma neurofilament light chain as a predictor of multiple system atrophy in idiopathic REM sleep behavior disorder

55/100 ✓ Peer-reviewed Biomarkers Journal of neurology

Key finding: Over 3.7 years, 22 patients phenoconverted (7 multiple system atrophy [MSA]; 15 Lewy body diseases [LBDs]). +4 more findings

• Biomarkers

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The concentration-dependent protective effects by new generation hypoglycemic agents on delirium, depression, dementia and coma: evidence from a network meta-analysis

62/100 ✓ Peer-reviewed Clinical safety Journal of the Royal Society of Medicine

Key finding: A total of 62 RCTs comprising 200,068 participants were included. +4 more findings

• Treatments

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Home-based, caregiver-assisted multimodal exercise and cognitive training via videoconferencing for older adults with mild dementia: A mixed-methods pilot study

39/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer s Disease

Key finding: Exploratory analyses suggested that compared with the control group, the CA-MECT participants showed potential improvements in global cognition, immediate recall, attention, number and severity of neuropsychiatric symptoms (NPS), and caregivers' distress, though no clear benefits were observed in functional ability or HRQoL. +1 more finding

• Lifestyle
• Caregiving

Full summary, score breakdown and related studies → Original source

Metabolomic aging clock predicts risk of different cardiovascular diseases in the UK Biobank

45/100 ✓ Peer-reviewed Long-term cohort studies Metabolism

Key finding: We found that this new measure accurately predicted actual PhenoAge (Pearson's r = 0.90) and was significantly associated with the incidence of seven CVDs, including major adverse cardiovascular events, atherosclerotic cardiovascular disease, myocardial infarction, stroke, aortic stenosis, heart failure, and abdominal aortic aneurysm, but not dementia. +3 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Barriers and Consequences of Prior Authorization for Neurologic Medications

62/100 ✓ Peer-reviewed Health systems and care delivery JAMA Neurology

Key finding: A total of 364 studies were identified using our search strategy on Ovid, 278 records were screened, and 20 studies were included in this review. +4 more findings

• Treatments

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Clinical effectiveness of music interventions for dementia and depression in older people (MIDDEL): a multinational, cluster-randomised controlled trial

64/100 ✓ Peer-reviewed Caregiving The Lancet Healthy Longevity

Key finding: Music Interventions for Dementia and Depression in Elderly care was a large, multinational, cluster-randomised controlled trial with a 2 × 2 factorial design to examine the effects of group music therapy, recreational choir singing, or both compared with standard care. +1 more finding

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Differences in survival and healthcare utilization amongst nursing home residents with advanced dementia and frailty compared to other end-of-life conditions: a retrospective cohort study

45/100 ✓ Peer-reviewed End-of-life care BMC Palliative Care

Key finding: Median survival was longer for residents with advanced dementia and frailty (16.5 months, 95%CI:13.5–19.5 months, P < 0.001) compared to incurable cancer (8.1 months, 95%CI:5.1–11.1 months, P < 0.001) and end-stage organ failure (7.7 months, 95%CI:3.0-12.4 months, P < 0.001). +4 more findings

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Molecular Crossroads: Shared and Divergent Molecular Signatures in Alzheimer’s Disease and Dementia with Lewy Bodies

41/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: Here, we discuss the current understanding of shared and unique clinical and neuropathological features of AD and DLB. +4 more findings

• Other Dementias
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Clinical validation of new alzheimer disease diagnosis tools based on plasma p-Tau217

43/100 ✓ Peer-reviewed Biomarkers Scientific Reports

Key finding: Such tools could significantly reduce the reliance on confirmatory tests that are invasive and costly, such as cerebrospinal fluid (CSF) biomarkers and neuroimaging. +2 more findings

• Biomarkers
• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

Long-term safety and efficacy of lecanemab in early Alzheimer's disease: Results from the Clarity AD open-label extension study

63/100 ✓ Peer-reviewed Clinical trials Alzheimer's & Dementia

Key finding: Benefit continued to accrue with ongoing lecanemab treatment through 36 months. +4 more findings

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source