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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 14,676–14,700 of 27,380 studies, newest first · page 588 of 1096.

October 2017 25

  1. 2017-10-11

    Doctor, Should I Use Computer Games to Prevent Dementia?

    ✓ Peer-reviewed Cognitive tests and assessment Clinical gerontologist

    Key finding: Commercial advertising of computerized "brain games" may result in clinicians being asked whether brain games prevent dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2017-10-10

    β-Amyloid and the Pathomechanisms of Alzheimer's Disease: A Comprehensive View

    ✓ Peer-reviewed Disease mechanisms Molecules (Basel, Switzerland)

    Key finding: Different cellular stress conditions result in the up-regulation of the neurotrophic, neuroprotective amyloid precursor protein (APP). +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2017-10-10

    Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

    ✓ Peer-reviewed Genetics eLife

    Key finding: Cerebral vessels play a major role in AD, as Aβ is cleared from the brain by pathways involving the cerebrovasculature, most AD patients have cerebrovascular amyloid (cerebral amyloid angiopathy (CAA), and cardiovascular risk factors increase dementia risk. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2017-10-10

    Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: ROC curves of the five best two-, three-, and four-parameter combinations were analyzed for significant superiority by a bootstrapping wrapper around a support vector machine with linear kernel. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2017-10-10

    Neuropsychological Measures that Predict Progression from Mild Cognitive Impairment to Alzheimer's type dementia in Older Adults: a Systematic Review and Meta-Analysis

    ✓ Peer-reviewed Mild cognitive impairment Neuropsychology review

    Key finding: Verbal memory measures and many language tests yielded very high predictive accuracy. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2017-10-10

    Neuroimaging Correlates of Cerebral Microbleeds: The ARIC Study (Atherosclerosis Risk in Communities)

    ✓ Peer-reviewed Brain scans and imaging Stroke

    Key finding: CMBs are a common vascular pathology in the elderly. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2017-10-10

    Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease

    ✓ Peer-reviewed Brain scans and imaging The EMBO journal

    Key finding: In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2017-10-09

    Discussing advance care planning: insights from older people living in nursing homes and from family members

    ✓ Peer-reviewed End-of-life care International psychogeriatrics

    Key finding: ABSTRACTBackground:Evidence concerning when and in which manner older people living in nursing homes (NHs) would prefer to discuss advance care planning (ACP) is still scarce. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2017-10-09

    TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

    ✓ Peer-reviewed TREM2 and immune genetics Proceedings of the National Academy of Sciences of the United States of America

    Key finding: In the brain, TREM2 is predominately expressed on microglia, and its association with AD adds to increasing evidence implicating a role for the innate immune system in AD initiation and progression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2017-10-07

    Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy

    ✓ Peer-reviewed Risk factors Ageing research reviews

    Key finding: Recently, it has been suggested that there is an inflammatory presence in the cochlea, perhaps involving diffusion processes of the blood-brain barrier as it relates to the inner ear.

    Full summary, score breakdown and related studies → Original source

  11. 2017-10-06

    Cerebral amyloid angiopathy-related cognitive impairment: The search for a specific neuropsychological pattern

    ✓ Peer-reviewed Vascular contributions Revue neurologique

    Key finding: CAA is also a risk factor for the development of dementia, and its relationship with Alzheimer's disease has been demonstrated in post-mortem studies.

    Full summary, score breakdown and related studies → Original source

  12. 2017-10-06

    Flortaucipir tau PET imaging in semantic variant primary progressive aphasia

    ✓ Peer-reviewed Brain scans and imaging Journal of neurology, neurosurgery, and psychiatry

    Key finding: All seven patients showed elevated FTP uptake in the anterior temporal lobe with a leftward asymmetry that was not observed in healthy controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2017-10-06

    Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical biology & medicine

    Key finding: Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer's Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21.

    Full summary, score breakdown and related studies → Original source

  14. 2017-10-06

    Tau-based therapies in neurodegeneration: opportunities and challenges

    ✓ Peer-reviewed Disease mechanisms Nature reviews. Drug discovery

    Key finding: Aggregates of the microtubule-associated protein tau are a defining feature of several neurodegenerative diseases that are collectively known as tauopathies, and constitute one of the hallmark lesions of Alzheimer disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2017-10-06

    Random Forest Algorithm for the Classification of Neuroimaging Data in Alzheimer's Disease: A Systematic Review

    ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

    Key finding: Twelve articles-published between the 2007 and 2017-have been included in this systematic review after a quantitative and qualitative selection. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2017-10-05

    Dying comfortably in very old age with or without dementia in different care settings - a representative "older old" population study

    ✓ Peer-reviewed End-of-life care BMC geriatrics

    Key finding: These findings are consistent with reports that care homes can provide care akin to hospice for the very old and support an approach of supporting residents to stay in their care home or own home if possible. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2017-10-04

    Biochemical and cellular properties of insulin receptor signalling

    ✓ Peer-reviewed Risk factors Nature reviews. Molecular cell biology

    Key finding: The latter predisposes to diseases ranging from hypertension to Alzheimer disease and cancer. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2017-10-04

    Bereavement support for family caregivers: The gap between guidelines and practice in palliative care

    ✓ Peer-reviewed End-of-life care PloS one

    Key finding: Timeliness and consistency of relationship is crucial to building rapport and trust in the service's ability to help at post-bereavement as well as a focus on the specific rather than the generic needs of the bereaved. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2017-10-04

    N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's research & therapy

    Key finding: The findings of this study are consistent with previous reports demonstrating a high aggregation propensity of Aβ 4-x peptides and suggest an important role of these N-truncated Aβ species in the process of amyloidogenesis and plaque core formation.

    Full summary, score breakdown and related studies → Original source

  20. 2017-10-03

    Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer's disease: an update

    ✓ Peer-reviewed Tau biomarkers Expert review of proteomics

    Key finding: However, pathological studies have shown that comorbidity is a common feature in AD and that the three currently used CSF biomarkers do not optimally reflect the activity of the disease process. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2017-10 month only

    Functional Connectivity of the Hippocampus in Early- and vs. Late-Onset Alzheimer's Disease

    ✓ Peer-reviewed Brain scans and imaging Journal of clinical neurology (Seoul, Korea)

    Key finding: The functional connectivity from the hippocampus to other brain regions differed between patients with EOAD and LOAD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2017-10-01

    Alzheimer's Disease: Past, Present, and Future

    ✓ Peer-reviewed Mild cognitive impairment Journal of the International Neuropsychological Society : JINS

    Key finding: During the 1980s our field began its foundational studies of profiling the neuropsychological deficits associated with AD and its differentiation from other dementias (e.g., cortical vs. subcortical dementias). +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2017-10-01

    Is Cancer Protective for Subsequent Alzheimer's Disease Risk? Evidence From the Utah Population Database

    ✓ Peer-reviewed Digital health tools The journals of gerontology. Series B, Psychological sciences and social sciences

    Key finding: Careful consideration of model specification and the profound effects of mortality selection in the older adult population is essential when investigating the relationship between aging-related diseases such as cancer and AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2017-10-01

    Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

    ✓ Peer-reviewed Genetics Cell reports

    Key finding: Furthermore, our work identified previously unobserved heterogeneity in the response of microglia to neurodegeneration, discovered disease stage-specific microglia cell states, revealed the trajectory of cellular reprogramming of microglia in response to neurodegeneration, and uncovered the underlying transcriptional programs.

    Full summary, score breakdown and related studies → Original source

  25. 2017-10-01

    Discontinuation of Preventive Medicines in Older People with Limited Life Expectancy: A Systematic Review

    ✓ Peer-reviewed End-of-life care Drugs & aging

    Key finding: The review found that withdrawal of preventive medicines at the end of life is challenging.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →