This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Nowadays, there is an unmet need for reliable and minimally-invasive diagnosis tools capable of detecting Alzheimer's disease at early stages. Such tools could significantly reduce the reliance on confirmatory tests that are invasive and costly, such as cerebrospinal fluid (CSF) biomarkers and neuroimaging. The aim of this study is to validate previously developed diagnosis tools (multivariate models and plasma p-Tau217 levels) in three independents cohorts. For this, a cohort was obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) including some variables (age, Apolipoprotein E (ApoE) genotype, plasma p-Tau217, CSF biomarkers) (n = 113); and two cohorts from cognitive disorders units (Hospital Universitari i Politècnic La Fe (HUiPLaFe, n = 163), Hospital Doctor Peset (n = 31)), whose plasma samples were analysed to determine plasma p-Tau217, and to evaluate the previous diagnosis tools performance. For the cohort from HUiPLaFe, the multivariate model (plasma p-Tau217, age, ApoE genotype) showed a sensitivity of 94.9% and a specificity of 88.2%; for the cohort from Hospital Doctor Peset, the sensitivity was 100% and specificity 80%; for the ADNI cohort, sensitivity was 89.5% and specificity 39.5%. Regarding the plasma p-Tau217 levels, the results were satisfactory for the cognitive disorders units; while ADNI cohort showed very low specificity. In conclusion, the multivariate model was clinically validated in independent cohorts from clinical units, representing its first step for implementation.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Martí-Navia, A., Álvarez‐Sánchez, L., Ferré‐González, L., López, A., Peña‐Bautista, C., Balaguer, Á., et al. (2025). Clinical validation of new alzheimer disease diagnosis tools based on plasma p-Tau217. Scientific Reports. https://doi.org/10.1038/s41598-025-31613-x

Vancouver

Martí-Navia A, Álvarez‐Sánchez L, Ferré‐González L, López A, Peña‐Bautista C, Balaguer Á, et al. Clinical validation of new alzheimer disease diagnosis tools based on plasma p-Tau217. Scientific Reports. 2025. doi:10.1038/s41598-025-31613-x. PMID: 41354755.

BibTeX

@article{martinavia2025-41354755,
  author  = {Martí-Navia, Aleix and Álvarez‐Sánchez, Lourdes and Ferré‐González, Laura and López, Alejandro and Peña‐Bautista, Carmen and Balaguer, Ángel and Pedrosa, N. Risueño and Vico, Helena and others},
  title   = {{Clinical validation of new alzheimer disease diagnosis tools based on plasma p-Tau217}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-31613-x},
  pmid    = {41354755},
  url     = {https://doi.org/10.1038/s41598-025-31613-x}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

Key findings

Such tools could significantly reduce the reliance on confirmatory tests that are invasive and costly, such as cerebrospinal fluid (CSF) biomarkers and neuroimaging.
Regarding the plasma p-Tau217 levels, the results were satisfactory for the cognitive disorders units; while ADNI cohort showed very low specificity.
In conclusion, the multivariate model was clinically validated in independent cohorts from clinical units, representing its first step for implementation.

Why it matters

A model using plasma p-Tau217, age and ApoE genotype detected Alzheimer's disease with good sensitivity and specificity in two clinical units but very low specificity in the ADNI cohort. This is a diagnostic validation and does not show any treatment or prevention effect.

New to this subject? Start with our plain-English guide: Blood tests & biomarkers →

Study details

Participants113
Effect size94.9%; 88.2%; 89.5%
Evidence strengthModerate

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Scientific Reports)
Journal's citation record	3 / 4	Scientific Reports: journal h-index 463 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	113 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Consuelo Cháfer‐Pericás: h-index 33 (OpenAlex, whole career)
Institution's track record	0 / 3	Hospital Universitari i Politècnic La Fe: institution h-index 376 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41354755)
Free to read	2 / 2	Free to read
Total	43 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Related studies in Biomarkers

Also tagged “phosphorylated”

733 studies in the library carry the topic tag “phosphorylated”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 733 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Biomarkers

See all studies in Biomarkers →