Newest studies

Optimizing mobile cognitive assessment reduces administration time while maintaining screening accuracy in older adults

47/100 ✓ Peer-reviewed Getting a diagnosis Scientific Reports

Key finding: By providing rapid, accurate remote assessment without additional equipment, DACI may significantly enhance accessibility of cognitive screening among older adults.

• Diagnosis

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Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease

63/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: A total of 807 K-ROAD participants (median age 72.0 years, 58.7% female) and 230 ADNI participants (median age 70.9 years, 49.1% female) were analyzed. +4 more findings

• Biomarkers
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes

45/100 ✓ Peer-reviewed Inflammation and the immune system Genome Medicine

Key finding: SnRNA-seq analysis revealed elevated microglial proportions across all dementia subtypes compared to NCI. +4 more findings

• Brain Biology

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TDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord

43/100 ✓ Peer-reviewed Brain tissue and pathology Acta Neuropathologica Communications

Key finding: This study examined the proteome associated with TDP-43 inclusions in ALS, using mass spectrometry-based proteomic analysis of spinal cord and cerebral cortex from donors with phosphoTDP-43 positive ALS (n = 16), alpha-synuclein positive Parkinson's disease (PD, n = 8), phosphotau and beta-amyloid positive Alzheimer's disease (AD, n = 8) and age matched non-neurological controls (n = 8), comparing ALS with non-ALS conditions, spinal cord with cerebral cortex samples, and detergent-soluble with -insoluble fractions. +4 more findings

• Brain Biology

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Tailored Dementia Care across Seven Swiss Memory Clinics: The CareMENS Model Improves Patients’ Mood and Quality of Life

40/100 ✓ Peer-reviewed Cognitive tests and assessment Neurodegenerative Diseases

Key finding: anxiety and depression symptoms (HADS), functional autonomy (DAD-6), global cognition (MoCA), and quality of life (WHOQOL). +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Fluid biomarkers in familial frontotemporal dementia: progress and prospects

32/100 ✓ Peer-reviewed Lewy body dementia Frontiers in Neurology

Key finding: Familial frontotemporal dementia (FTD) is a genetically heterogeneous disease with various clinical manifestations, making it difficult to diagnose. +4 more findings

• Biomarkers
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Proteomic signature of dementia risk in type 2 diabetes

50/100 ✓ Peer-reviewed Digital health tools Journal of Advanced Research

Key finding: We identified 471 proteins with significant interaction effects between T2D and dementia risk. +4 more findings

• Risk Factors

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Intersectional research on dementia care for post-migrants and ethnic minority groups: a scoping review

53/100 ✓ Peer-reviewed Disparities Frontiers in Dementia

Key finding: Limited studies focusing on the intersectional determinants of preferences of ethnic minority groups or post-migrants with dementia were found. +4 more findings

• Health Equity

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Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association

49/100 ✓ Peer-reviewed Caregiving Stroke

Key finding: Vascular contributions to cognitive impairment and dementia (VCID) are common and may be the most preventable cause of clinically significant cognitive decline. +2 more findings

• Risk Factors
• Brain Scans

Full summary, score breakdown and related studies → Original source

A Scoping Review of Clinical Utility from the Montreal Cognitive Assessment Memory Index Score

37/100 ✓ Peer-reviewed Getting a diagnosis Journal of Geriatric Psychiatry and Neurology

Key finding: Peer-reviewed studies that reported data on the diagnostic or prognostic utility of the MIS in assessing neurodegenerative dementia populations were included. +4 more findings

• Diagnosis

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Self-Reported Hearing Aid Use and Risk of Incident Dementia

56/100 ✓ Peer-reviewed Prevention and risk JAMA Neurology

Key finding: This cohort study compares the risk of incident all-cause dementia among people with hearing loss who use vs do not use hearing aids.

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Multilevel and multidimensional features of socioeconomic status and cognitive function in older adulthood: a cross-sectional analysis of the IGNITE study

43/100 ✓ Peer-reviewed Risk factors The Lancet Regional Health - Americas

Key finding: [95% CI] = 0.148 [0.077-0.219]; executive function, 0.138 [0.067-0.208]; episodic memory, 0.020 [-0.051 to 0.091]; working memory, 0.128 [0.059-0.197]; visuospatial processing, 0.094 [0.023-0.164]) outperformed area-level SES in detecting cognitive deficits, and demonstrated widespread associations with poorer performance across cognitive domains. +4 more findings

• Health Equity

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Mixed Pathologies and Cognitive Outcomes in Persons Considered for Anti-Amyloid Treatment Eligibility Assessment: A Community-Based Study

46/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Among 428 older autopsied persons (mean age at death = 91 years, 70% women) considered for anti-amyloid treatment eligibility assessment, 58% had MCI and 42% had mild-stage Alzheimer dementia. +4 more findings

• Treatments
• Brain Biology

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Emotion regulation strategies to improve outcomes in family caregivers of people with Alzheimer's disease and related dementias: A systematic review

71/100 ✓ Peer-reviewed Caregiving Journal of health psychology

Key finding: We hypothesized that the inclusion of adaptive strategies like cognitive reappraisal would be associated with significant outcomes, rather than the number of trained strategies. +3 more findings

• Caregiving
• Policy

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Palliative Care Needs of Older Adults With and Without Dementia During Post-Acute Care in Skilled Nursing Facilities

49/100 ✓ Peer-reviewed End-of-life care Journal of Applied Gerontology

Key finding: While there was no statistically significant difference in PC needs between the two groups, the most prevalent PC needs for all were pain (63.5%), feeling anxious or worried (59.6%), family and friends being anxious or worried (57.7%), and need for information (46.2%).

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Cross-cultural functional assessment for dementia: A commentary

42/100 ✓ Peer-reviewed Disparities The Clinical Neuropsychologist

Key finding: We critically examine methodological limitations in current functional assessment tools, including poor cultural adaptability, inadequate validation processes, and limited stakeholder engagement. +4 more findings

• Health Equity

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Physical Activity and the Myokine Irisin in Non-pharmacological Treatment of Alzheimer Disease

29/100 ✓ Peer-reviewed Disease mechanisms Russian Journal of Physiotherapy Balneology and Rehabilitation

Key finding: Preclinical studies have demonstrated that irisin improves memory performance, spatial learning, and synaptic plasticity in animal models of AD. +1 more finding

• Brain Biology
• Lifestyle
• Treatments

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Identifying the optimal combinations of modifiable dementia risk factors to target in multidomain intervention – Three-year longitudinal findings from the Canadian longitudinal study on aging

51/100 ✓ Peer-reviewed Prevention trials The Journal of Prevention of Alzheimer s Disease

Key finding: The combinations that were both highly prevalent and had the most detrimental effect on global cognition were: hearing loss and physical inactivity for the dyad (mean difference in change score = -0.07 SD; 95 % CI: -0.09 to -0.06; p < 0.001; effect size = -0.28), hearing loss, physical inactivity, and hypertension for the triad (mean difference in change score = -0.07; 95 % CI: -0.09 to -0.06; p < 0.001; effect size = -0.28), and hearing loss, physical inactivity, hypertension, and sleep disturbance for the tetrad (mean difference in change score = -0.05; 95 % CI: -0.07 to -0.03; p < 0.001; effect size = -0.20). +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Detecting amyloid and tau pathology in Parkinson’s disease, 4R-tauopathies and control subjects with plasma pTau217

48/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Neurology

Key finding: Plasma pTau217 levels serve as a scalable, non-invasive marker of AD-pathology across Lewy body diseases, PSP/CBS, and MCI/CU populations. +1 more finding

• Biomarkers
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Disrupted Calcium Dynamics in Reactive Astrocytes Occur with End Feet–Arteriole Decoupling in an Amyloid Mouse Model of Alzheimer's Disease

40/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroscience

Key finding: Moreover, end feet calcium transients following arteriole dilations exhibited a slower onset, reduced amplitude, and lacked relative proportionality to vasomotive activity compared with WTs. +2 more findings

• Brain Biology

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Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids

41/100 ✓ Peer-reviewed Risk genes beyond APOE Stem Cell Reports

Key finding: Here, we developed cerebral organoids from induced pluripotent stem cells (iPSCs) with mutations in amyloid precursor protein (APP) associated with familial AD (fAD) and analyzed the dynamic changes of cellular states. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Unraveling the conformational landscape of amyloid precursor protein intracellular domain

35/100 ✓ Peer-reviewed Risk genes beyond APOE Biophysical Journal

Key finding: Our results reveal that AICD fluctuates between compact and extended states, exhibiting dynamic secondary structure elements and heterogeneous solvent accessibility. +1 more finding

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Mitochondrial Reactive Oxygen Species Production in Vascular Dementia Following Experimental Diabetes

35/100 ✓ Peer-reviewed Risk factors Cells

Key finding: Our findings indicated that significant cognitive impairment, memory loss, and vascular dementia occurred in male and female T1D mice. +2 more findings

• Brain Biology
• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Insomnia Phenotypes, Cardiovascular Risk and Their Link to Brain Health

50/100 ✓ Peer-reviewed Risk factors Circulation research

Key finding: In fact, recent meta-analytic evidence from epidemiological studies has demonstrated that insomnia, especially when accompanied by objective short sleep duration, is a risk factor for incident hypertension, type 2 diabetes, heart failure, stroke, cognitive impairment, Alzheimer disease, and all-cause mortality. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis

89/100 ✓ Peer-reviewed Drug development BMJ (Clinical research ed.)

Key finding: The systematic review and NMA includes 493 168 participants from 869 trials (adding 53 trials since October 2022) reporting data for 13 drug classes (63 drugs) and 26 outcomes of interest. +4 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source