Newest studies

Implementation of a standardized Video-based Asynchronous Neurological Examination (VANE) in a multi-center observational study of Alzheimer’s disease (AD) and AD related dementias

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: Engaging 55 research staff across 25 sites and 3 physician-reviewers, this study is the first to demonstrate feasibility of a VANE as an efficient neurological examination model enabled by commonly used devices. +1 more finding

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Episodic memory ERPs reflect preclinical Alzheimer’s disease progression

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis bioRxiv

Key finding: Structured Abstract Background Alzheimer’s disease (AD) neuropathology emerges decades before symptoms, requiring sensitive, non-invasive markers for early diagnosis. +1 more finding

• Early Stage

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Chart review and genetic validation of electronic medical record dementia diagnoses in VA: The impact of CMS data

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: We recommend using a broad (ADRD) algorithm without CMS or medication data, particularly for epidemiological studies or a strict AD algorithm including CMS and medication cases for genetic discovery of late-onset AD associations in VA EMR, and a strict AD algorithm without CMS data for applications focused solely on AD and sensitive to misspecification. +2 more findings

• Policy
• Genetics

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Reversibility and Access: A Two-Axis Framework for Glucagon-Like Peptide-1 Receptor Agonists Across the Neurological Spectrum, and a Falsifiable Analgesic Hypothesis for Chronic Migraine

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Preprints.org

Key finding: The first is tissue reversibility, which determines whether disease modification is possible at all: a remodellable vascular substrate responds, an autonomously degenerating parenchyma does not, and a functionally disordered but structurally intact network should. +4 more findings

• Clinical Trials

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Initial Technical and Clinical Validation of Mobile Pupillometry with Virtual Reality: A Digital Biomarker for Screening Cognitive Function and Impairment

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment medRxiv

Key finding: Mixed effects models revealed that similar to lab-based eye-tracking systems, pupil size increased in a sensible and distinguishable fashion as a function of working memory load. +3 more findings

• Digital Tools
• Diagnosis
• Biomarkers

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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End-of-life and Palliative Care in Dementia: An Overview for Clinicians

34/100 ✓ Peer-reviewed End-of-life care Current Treatment Options in Neurology

Key finding: Awareness of caregiver distress, burnout, and early grief, as a result of the loss of their loved one’s personhood, has increased. +2 more findings

• End-of-Life Care

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Mediterranean Diet and Neurodegenerative Diseases: Recent Advances from the Gut–Immune–Brain Axis to Multi-Omics-Guided Precision Nutrition

41/100 ✓ Peer-reviewed Prevention trials Cells

Key finding: The Mediterranean diet, rich in plant-based foods, olive oil, and fish, has been consistently associated with slower cognitive decline and reduced risk of neurodegeneration in observational studies and some clinical trials. +3 more findings

• Lifestyle
• Brain Biology

Full summary, score breakdown and related studies → Original source

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk

40/100 ✓ Peer-reviewed Risk genes beyond APOE Nature Communications

Key finding: We report the results of structural, functional and genetic studies on the CD33 sialic acid- binding receptor that reveal how non-coding variants in CD33 alter risk for Alzheimer’s disease (AD). +1 more finding

• Genetics
• Brain Biology

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Entropy Anatomy of Pre-Agitation Activity Disruption in the TIHM Home-Monitoring Cohort

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Research Square

Key finding: Agitation days showed higher median sample entropy (1.23 vs 1.06; p<0.001) and approximate entropy (1.24 vs 1.08; p<5 × 10−19). +4 more findings

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Curation of Mini Mental State Examination (MMSE) Scores in the VA Million Veteran Program (MVP): Applications for Cognitive Aging Research

16/100 ⚠ Preprint — not yet peer-reviewed Disparities medRxiv

Key finding: This study demonstrated MMSE scores can be systematically extracted and curated from the VA EHR. +2 more findings

• Diagnosis
• Genetics

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Exploration of the molecular origins of sex-specific and temporal comorbidity patterns in dementia: insights from the Austrian claims data

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv

Key finding: Recent estimates suggest that more than half of all dementia cases could be preventable by addressing their risk factors, including disease comorbidities such as diabetes and vision loss. +2 more findings

• Prevention

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A non-canonical androgen signaling pathway drives microglial activation and tau pathology in females

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics Research Square

Key finding: Together, our findings uncover a non-canonical DHT–TR4– Trem2 signaling axis in microglia and identify TR4 as a key regulator of neuroinflammation in female neurodegeneration, providing mechanistic insight into female-specific vulnerability to AD.

• Brain Biology
• Genetics

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Predictive value of plasma p-tau217 for Alzheimer's dementia compared to other blood-based biomarkers

75/100 ✓ Peer-reviewed Biomarkers EMBO molecular medicine

Key finding: Associations with AD were assessed and compared to those with previous measurements of p-tau181, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP). +2 more findings

• Biomarkers
• Brain Biology

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Population Attributable Risk in Alzheimer and Parkinson Diseases

55/100 ✓ Peer-reviewed Genetics Neurology Genetics

Key finding: ObjectivesEmerging evidence suggests that the genetic architecture of Alzheimer disease (AD) and Parkinson disease (PD) risk varies across ancestries. +3 more findings

• Genetics
• Other Dementias

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Associations of [ 18 F]PI-2620 Binding with Memory and Phosphorylated Tau 217 in Cognitively Unimpaired Older Adults

40/100 ✓ Peer-reviewed Biomarkers Journal of Nuclear Medicine

Key finding: In older adults, temporal [18F]PI-2620 binding was higher in women (β = 0.543, P < 0.001) and APOE4 carriers (β = 0.395, P = 0.030) and was positively associated with plasma p-tau217 (β = 0.22, P = 0.008). +3 more findings

• Biomarkers

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Anemia, iron deficiency, and blood biomarkers for Alzheimer disease: clinical interpretation and dementia risk stratification

30/100 ✓ Peer-reviewed Biomarkers Frontiers in Nutrition

Key finding: Among available analytes, p-tau217 is closest to routine clinical use within validated intended-use diagnostic pathways; however, its interpretation remains assay- and cutoff-specific and depends on pretest probability, gray-zone handling, kidney function, BMI, hemoglobin, ferritin, and transferrin saturation. +4 more findings

• Biomarkers
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

The Prognostic Value of Genetic Architectures in Cognitive Decline

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment medRxiv

Key finding: The unsupervised machine learning pipeline successfully identified a composite genetic cluster that emerged as an influential predictor in terms of relative magnitude ( η p 2 ). +4 more findings

• Diagnosis
• Genetics

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Multidomain lifestyle interventions for the risk reduction of cognitive impairment and dementia: A systematic review and meta-analysis

16/100 ⚠ Preprint — not yet peer-reviewed Prevention trials medRxiv

Key finding: Multidomain interventions have small but consistent beneficial effects on cognitive measures, suggesting the potential to reduce cognitive impairment and dementia risk. +2 more findings

• Prevention
• Clinical Trials
• Risk Factors

Scored 58 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Single-cell gene networks nominate IKZF1 as an Alzheimer’s microglial regulator

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: IKZF1 is prioritised as a candidate late-disease microglial TF, supported by six convergent evidence dimensions including independent bulk replication.

• Treatments
• Genetics
• Brain Biology

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Orthogonal Contributions of Genetic, Clinical, and Social Determinants of Health Risk Burdens on Alzheimer’s Disease Pathophysiology

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

Key finding: Genetic risks were primarily associated with Aβ and tau pathology, clinical risks with neurodegeneration, and SDoH risks with cognition, suggesting that risk factors exert differential effects on AD pathophysiology. +4 more findings

• Genetics
• Health Equity

Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Neurovascular Outer Retinal Degeneration in Presymptomatic Alzheimer’s Disease: An Oculomic Biomarker Study

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

Key finding: These findings demonstrate spatially concordant vascular and neuronal degeneration in the outer retina in preclinical AD. +2 more findings

• Biomarkers

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Real-world safety and implementation challenges of lecanemab therapy for Alzheimer's disease in South Korea: a single-center experience

37/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's research & therapy

Key finding: Only 1 patient with isolated ARIA-H presented with transient confusion. +4 more findings

• Treatments
• Side Effects

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Detecting Alzheimer’s Disease through Chinese Speech: A Contrast of Manual and Automatic Linguistic Feature Extraction

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools PsyArXiv

Key finding: Recent research has revealed that linguistic features are effective digital markers for the early detection of Alzheimer’s disease (AD). +4 more findings

• Diagnosis
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Alert Policy and Rare-Event Metrics for Seven-Day-Ahead Agitation Forecasting in Passive Dementia Monitoring

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Research Square

Key finding: Default thresholds yielded 20–23% precision with 94– 100% recall—unacceptable for caregiver-facing alerts. +4 more findings

• Policy

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Real-World Outcomes of a Telephone-Based Virtual Cognitive Rehabilitation Therapy Program: A Retrospective Cohort Analysis

16/100 ⚠ Preprint — not yet peer-reviewed Disparities medRxiv

Key finding: Changes in four outcome measures from initiation of treatment to discharge were evaluated for statistical significance: quality of life and three therapist-rated Functional Communication Measures (FCMs) of overall cognition, language expression, and language comprehension. +4 more findings

• Health Equity
• Treatments

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source