Newest studies

Relapsing Remitting Rapidly Progressive Dementia Due to Cerebral Amyloid Angiopathy-Related Inflammation (P11-3.012)

33/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: This report highlights a case of relapsing remitting rapidly progressive dementia due to cerebral amyloid angiopathy-related inflammation (CAA-ri), focusing on the diagnostic challenges and the dramatic response to corticosteroid treatment.

• Brain Biology

Full summary, score breakdown and related studies → Original source

A pilot study investigating the effectiveness, appreciation, and feasibility of a cognitive stimulation program in dementia patients: online versus face-to-face

38/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Psychology

Key finding: No significant differences were found between the in-person and remote groups in terms of age, education, or gender. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related Dementias

61/100 ✓ Peer-reviewed How common it is JAMA Neurology

Key finding: This study included 33 858 patients in the GLP-1RA vs other GLD cohort (mean age, 65 years; 53.1% female), 34 185 patients in the SGLT2i vs other GLD cohort (mean age, 65.8 years; 49.3% female), and 24 117 patients in the GLP-1RA vs SGLT2i cohort (mean age, 63.8 years; 51.7% female). +4 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Loneliness among dementia caregivers: evaluation of the psychometric properties and cutoff score of the Three-item UCLA Loneliness Scale

49/100 ✓ Peer-reviewed Caregiving Frontiers in Psychiatry

Key finding: One factor accounted for 79.0% of the variance in the UCLALS3; it was perfectly invariant across genders but variant at the metric level across countries. +4 more findings

• Caregiving
• Lifestyle

Full summary, score breakdown and related studies → Original source

Comparison of MK-6240 and Flortaucipir Tau PET for the Biological Staging of Alzheimer Disease (P11-4.004)

39/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: We aim to compare the biological staging of Alzheimer Disease using two different tau PET tracers.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Concurrent validity, test–retest reliability, and normative properties of the ignite app: A cognitive assessment for frontotemporal dementia

39/100 ✓ Peer-reviewed Getting a diagnosis Neuropsychology

Key finding: 90%) rated the app favorably, stating it was enjoyable and easy to complete unsupervised. +3 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Degree of Adherence to Brain Health Recommendations in Patients Pursuing Anti-Amyloid Antibody Therapy for Alzheimer’s Disease (S23.003)

35/100 ✓ Peer-reviewed Treatments Neurology

Key finding: To determine the degree to which patients with early Alzheimer disease (AD) being evaluated for anti-amyloid antibody therapies (AATs) adhere to optimal brain-health/lifestyle recommendations.

• Treatments

Full summary, score breakdown and related studies → Original source

Performance of Alzheimer Disease Plasma Biomarkers in a Specialty Memory Clinic (S15.005)

34/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Evaluate the performance of emerging Alzheimer disease (AD) plasma biomarkers in a specialty memory clinic.

• Biomarkers
• Care Services

Full summary, score breakdown and related studies → Original source

Clinical Benefits and Risks of Antiamyloid Antibodies in Sporadic Alzheimer Disease: Systematic Review and Network Meta-Analysis With a Web Application

62/100 ✓ Peer-reviewed Drug development Journal of medical Internet research

Key finding: Despite the increasing approval of antiamyloid antibodies for Alzheimer disease (AD), their clinical relevance and risk-benefit profile remain uncertain. +3 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Preventable adverse events and related outcomes among people with dementia in hospital settings: scoping review

34/100 ✓ Peer-reviewed Clinical safety Aging & Mental Health

Key finding: Of the 1976 retrieved studies, 16 were included. +4 more findings

• Side Effects
• Care Services

Full summary, score breakdown and related studies → Original source

Clarity AD: Asian regional analysis of a phase III trial of lecanemab in early Alzheimer's disease

58/100 ✓ Peer-reviewed Treatments The Journal of Prevention of Alzheimer s Disease

Key finding: Of the total of 1795 subjects randomized in Clarity AD, 294 subjects were in the Asian region (Japan:152; Korea:129; Singapore:13). +4 more findings

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Co-calibration of cognitive performance in the National Health and Aging Trends Study with the Health and Retirement Study's Harmonized Cognitive Assessment Protocol: Implications for dementia classification

45/100 ✓ Peer-reviewed Getting a diagnosis SSM - Population Health

Key finding: Study-specific algorithms yielded comparable dementia prevalence estimates: 10.8 % in NHATS and 11.1 % in HRS-HCAP. +4 more findings

• Diagnosis
• Health Equity

Full summary, score breakdown and related studies → Original source

The impact of gut microbial short-chain fatty acids on colorectal cancer development and prevention

51/100 ✓ Peer-reviewed Prevention and risk Gut Microbes

Key finding: Maintaining a healthy gut microbiome is crucial for overall health, and short-chain fatty acids (SCFAs) produced by gut microbiota play a vital role in this process. +2 more findings

• Prevention

Full summary, score breakdown and related studies → Original source

Intrinsic factors associated with engagement in healthy lifestyle behaviors for dementia risk reduction in midlife

40/100 ✓ Peer-reviewed Prevention and risk Alzheimer s & Dementia Behavior & Socioeconomics of Aging

Key finding: LPA identified four intrinsic profiles: Profile 1 had low motivation; Profile 2 had high motivation and self-efficacy, but poor dementia knowledge; Profile 3 had moderate motivation; and Profile 4 had low motivation and high apathy. +4 more findings

• Prevention
• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

The impact of tract‐ and county‐level segregation on 10‐year cognitive and everyday functioning outcomes of Black/African American older adults in the ACTIVE study

43/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia Behavior & Socioeconomics of Aging

Key finding: Higher segregation, indicated by lower tract and county-level interaction, was associated with better cognitive and everyday functioning levels but faster rates of decline. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Aging and disease

Key finding: Down syndrome (DS), caused by trisomy of chromosome 21 (HSA21), is a complex condition associated with neurodevelopmental impairments and accelerated brain aging, often culminating in early-onset Alzheimer's disease (AD).

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden

57/100 ✓ Peer-reviewed Vascular contributions Alzheimer s Research & Therapy

Key finding: Participants' median age was 70.7 years (Q1-Q3 = 67.8-74.0), with 52.4% being women. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Traumatic Brain Injury and Chronic Traumatic Encephalopathy: Not Only Trigger for Neurodegeneration but Also for Cerebral Amyloid Angiopathy?

40/100 ✓ Peer-reviewed Brain tissue and pathology Biomedicines

Key finding: Epidemiological studies indicate that TBI increases the risk of various dementias, not solely AD, emphasizing the need for a comprehensive understanding of TBI-related neurodegeneration as a polypathological condition. +1 more finding

• Brain Biology
• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Exploring the Role of microRNAs as Blood Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia

45/100 ✓ Peer-reviewed Lewy body dementia International Journal of Molecular Sciences

Key finding: AD is characterized by the accumulation of amyloid-β (Aβ) plaques and hyperphosphorylated tau in the brain, leading to progressive memory loss and cognitive decline, significantly impairing daily life. +1 more finding

• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source

Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration

43/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer s Research & Therapy

Key finding: These models revealed distinct network configurations corresponding to the patient's cognitive condition, with virtual neurodegeneration levels directly proportional to the severity of cognitive decline. +1 more finding

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Central Insulin-like Growth Factor-1 Treatment Enhances Working and Reference Memory by Reducing Neuroinflammation and Amyloid Beta Deposition in a Rat Model of Sporadic Alzheimer’s Disease

36/100 ✓ Peer-reviewed Inflammation and the immune system Pharmaceuticals

Key finding: We found that ICVIGF-1 administration protected working memory demonstrated as (1) reduced latency to reach the platform, and reduced swimming distance in trials 3 (p < 0.05) and 4 (p < 0.01) on days 45 and 90 post-injection and (2) a short-term (up to 45 days post-injection) enhancement of reference memory, manifested by a reduction in swimming distance and latency (p < 0.05). +2 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes

62/100 ✓ Peer-reviewed Prevention and risk Circulation

Key finding: A total of 8870 cases of all-cause dementia were observed over a median 13.9-year follow-up. +4 more findings

• Risk Factors
• Genetics
• Lifestyle

Full summary, score breakdown and related studies → Original source

Data-Driven Modeling of Amyloid-beta Targeted Antibodies for Alzheimer’s Disease

40/100 ✓ Peer-reviewed Treatments NPJ systems biology and applications

Key finding: The results indicate that Donanemab achieves the most significant reduction in fibrils. +1 more finding

• Treatments
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

A more irregular shape of white matter hyperintensities is associated with cognitive decline over five years in community-dwelling older adults

46/100 ✓ Peer-reviewed Vascular contributions Neurobiology of Aging

Key finding: WMH shape is associated with long-term risk for dementia after 10 years in community-dwelling older adults. +1 more finding

Full summary, score breakdown and related studies → Original source

Diet Quality Indices, All-Cause Mortality, Cardiovascular Disease, and Dementia—Outcomes from the Australian Longitudinal Study on Women’s Health

55/100 ✓ Peer-reviewed Prevention trials Journal of Nutrition

Key finding: There were 656 deaths, 1585 incidents of CVD and 165 dementia diagnoses during 17.2 years of follow-up. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source