Newest studies

Microbiome-targeted Alzheimer's interventions via gut-brain axis

43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in microbiology

Key finding: This dysbiosis, characterized by a reduction in beneficial microbes and an increase in pro-inflammatory taxa, compromises intestinal and blood-brain barrier integrity, promoting systemic inflammation and the translocation of neurotoxic agents like lipopolysaccharide (LPS). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Long-Term Effects of Mobile-Based Metamemory Cognitive Training in Older Adults With Mild Cognitive Impairment: 15-Month Prospective Single-Arm Longitudinal Study

34/100 ✓ Peer-reviewed Prevention trials JMIR Aging

Key finding: Greater cognitive improvements were associated with younger age, higher functional status, and lower baseline cognitive function. +2 more findings

• Lifestyle

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Epilepsia como manifestación temprana en el espectro de la enfermedad de Alzheimer: explorando la variante epiléptica

26/100 ✓ Peer-reviewed Risk genes beyond APOE Acta neurológica colombiana

Key finding: Por lo tanto, la epilepsia es una comorbilidad frecuente en la EA de inicio temprano. +4 more findings

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Qualitative Evaluation of an Online Technology to Support Rural Caregivers of People with Dementia

32/100 ✓ Peer-reviewed Disparities Geriatrics

Key finding: Key barriers included limited digital literacy, resistance to technology and privacy concerns, as well as competing organisational priorities, and inadequate technological infrastructure. +3 more findings

• Digital Tools
• Health Equity
• Caregiving

Full summary, score breakdown and related studies → Original source

Clinical, Biological, and Functional Connectivity Profile of Patients With De Novo Parkinson Disease Who Are APOE ε4 Carriers

42/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Growing evidence suggests that the APOE ε4 allele, a genetic risk factor for Alzheimer disease (AD), influences the clinical-pathologic features of Parkinson disease (PD).

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Cognitive screening biases in a secondary prevention Alzheimer’s disease clinical trial

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: Biases in cognitive/functional screening tests may disproportionately exclude ethnoracial minorities in AD prevention trials.

• Diagnosis
• Clinical Trials
• Treatments

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Dementia and communication comorbidities within the context of caregiver support systems: a scoping review

71/100 ✓ Peer-reviewed Caregiving BMC geriatrics

Key finding: A total of 228 articles were screened at the title and abstract levels, and 120 full-text articles were assessed for eligibility. 23 eligible studies were included in the narrative synthesis. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Early proteasome downregulation and dysfunction drive proteostasis failure in Alzheimer's disease

46/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology

Key finding: Here, we integrated multiple approaches to characterize proteasome function, composition and regulation in post-mortem human AD brain tissue compared with age-matched controls. +3 more findings

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Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis

48/100 ✓ Peer-reviewed Genetics Aging cell

Key finding: Major depressive disorder (MDD) is linked to a higher risk of premature aging, but the mechanisms underlying this association remain unclear. +4 more findings

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CRISPR editing of miR-33 restores ApoE lipidation and amyloid-β metabolism in ApoE4 sporadic Alzheimer's disease

46/100 ✓ Peer-reviewed Genetics Brain : a journal of neurology

Key finding: Our results show that targeted miR-33 regulation in astrocytes via CRISPR/Cas9 restores ApoE lipidation and mitigates AD pathology in both in vitro and in vivo AD mice. +1 more finding

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Influence of patient characteristics on efficacy and safety of anti-amyloid monoclonal antibodies in Alzheimer's disease: A systematic review and meta-analysis

81/100 ✓ Peer-reviewed Treatments Ageing research reviews

Key finding: The efficacy and safety of anti-amyloid mAbs in AD may differ based on patients' demographic and genetic factors. +3 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

The White Matter Hyperintensity Shape and Brain Clearance (WHIMAS) Study for Identification of Novel 7T Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease: Protocol for a Cross-Sectional Study

40/100 ✓ Peer-reviewed Vascular contributions JMIR Research Protocols

Key finding: Patient inclusion started in January 2023, and study enrollment of patients is expected to finish in the second quarter of 2027, whereas the main results are expected to be published in the first quarter of 2028. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Saccade Tasks: A Noninvasive Approach for Predicting Postoperative Delirium in Elderly Arthroplasty Patients

45/100 ✓ Peer-reviewed Clinical safety Anesthesiology

Key finding: The incidence of POD was 8.2% (26 of 316). +4 more findings

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PS19 mouse tauopathy is associated with sex-dependent sleep loss and hyperarousal, and predicts cognitive performance

46/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of Aging

Key finding: PS19s demonstrated profound sleep loss, and locomotor hyperarousal; paralleling observations in AD patients and other studies of mouse tauopathy. +2 more findings

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Association between anosognosia and neuropsychiatric symptoms in Alzheimer’s disease dementia patients

54/100 ✓ Peer-reviewed Cognitive tests and assessment Scientific Reports

Key finding: In those with anosognosia at baseline, we observed a trend toward greater prevalence of agitation and motor symptoms. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Alzheimer disease predicting from clinical and MRI data using DeepALZNET dual pathway framework

35/100 ✓ Peer-reviewed Brain scans and imaging Scientific Reports

Key finding: Alzheimer's Disease (AD) is a significant neurological condition characterized by progressive cognitive deterioration, with prevalence rising exponentially with age. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Regional disparities of antidementia drug treatment in Germany: what can we learn for the new generation of Alzheimer’s therapies

44/100 ✓ Peer-reviewed Risk factors Alzheimer s Research & Therapy

Key finding: Overall, 64% of PlwAD received at least one AD-Rx. +4 more findings

• Treatments
• Health Equity

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Human Wild-Type α-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of Synucleinopathy

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology Research square

Key finding: Prior work has shown that this model develops α-Syn pathology across key brain regions, including the substantia nigra, cortex, hippocampus, and striatum, accompanied by microglial activation and synaptic dysfunction. +2 more findings

• Brain Biology
• Other Dementias

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Exploring Centiloid Robustness: Impact of Sample Size and Image Resolution on Centiloid Conversion Accuracy

52/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: In the smallest required sample of 15 cAD and 10 Aβ-negative participants, conversion error was 1.7 Centiloids at 25 Centiloids and 3.4 Centiloids at 100 Centiloids. +4 more findings

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Family carers' knowledge and practices in dementia care for hospitalized older adults: a multi-center cross-sectional study in Thailand

41/100 ✓ Peer-reviewed End-of-life care Frontiers in Medicine

Key finding: Carers' knowledge about dementia was moderate overall, with higher scores among those with greater education and previous dementia exposure. +4 more findings

• Caregiving
• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants

46/100 ✓ Peer-reviewed Long-term cohort studies BMC Medicine

Key finding: The mean age of the sample was 63 years (Q1, Q3, 56, 68); 56% were women. +4 more findings

• Lifestyle
• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Individualized prediction of clinical progression to dementia using plasma biomarkers in non-demented elderly

46/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s Research & Therapy

Key finding: During follow-up 20 SCD and 99 MCI patients developed dementia. +4 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Longitudinal assessment of cognitive decline and resilience in high-level Alzheimer disease neuropathologic change

56/100 ✓ Peer-reviewed Genetics Alzheimer s Research & Therapy

Key finding: Individuals with rapid progression were more likely to have at least one APOE ε4 allele (OR: 2.08 [95% CI: 1.16–3.74], p < 0.01), higher Braak stage (2.19 [1.20–3.98], p < 0.01), higher Thal phase (2.45 [1.24–4.83], p < 0.01), more severe white matter rarefaction (1.68 [1.21–2.35], p < 0.01), and in the final 24 months of life, more frequent untreated/undertreated hyperlipidemia (1.74 [1.35–5.56], p < 0.01) and less frequent untreated/undertreated depression (0.40 [0.17–0.91], p < 0.05). +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Kidney Function, Alzheimer Disease Blood Biomarkers, and Dementia Risk in Community-Dwelling Older Adults

68/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: At baseline, 2,279 dementia-free participants with available blood samples were included (median age 72 (interquartile range, 61-81) years; 62% female). +3 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

The effects of nicotine on neurocognitive outcomes: evidence from a polygenic risk score analysis

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv

Key finding: Our findings demonstrate differential effects of nicotine on AD risk and smoking intensity on white matter integrity, requiring triangulation with complementary methodological approaches to better inform potential long-term risks of nicotine intake on neurocognitive outcomes. +2 more findings

• Genetics

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source