Newest studies

Usability and feasibility of INFORMA platform for computerized cognitive stimulation in mild cognitive impairment and early dementia: an 8-week multicenter study

45/100 ✓ Peer-reviewed Cognitive tests and assessment Aging Clinical and Experimental Research

Key finding: Of 219 completing participants (mean age 73.5 years), the mean SUS score was 82.0 (95% CI: 80.3-83.8), with 84% exceeding the usability threshold (SUS score > 68). +4 more findings

• Early Stage
• Lifestyle
• Digital Tools

Full summary, score breakdown and related studies → Original source

Progress in Machine Learning-Assisted Biosensors for Alzheimer’s Disease

38/100 ✓ Peer-reviewed Digital health tools Biosensors

Key finding: This disease is associated with changes in the concentration of AD biomarkers, such as microRNAs, amyloid peptides, Tau protein, and neurofilament light chains.

• Digital Tools
• Brain Biology

Full summary, score breakdown and related studies → Original source

Late-life body mass index and Alzheimer disease conversion in mild cognitive impairment: Nonlinear risk and structural MRI correlates

40/100 ✓ Peer-reviewed Brain scans and imaging Archives of Gerontology and Geriatrics

Key finding: Over a median follow-up of 3.26 years, 321 participants converted to AD. +4 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Amyloid spatial extent with florbetapir-PET for early detection of preclinical Alzheimer’s disease

46/100 ✓ Peer-reviewed Treatments The Journal of Prevention of Alzheimer s Disease

Key finding: EXT showed high cross-sectional reliability and longitudinal stability. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Additional file 1 of Telehealth among Medicare Advantage beneficiaries with and without Alzheimer's Disease and Related Dementias (ADRD), 2018–2024: from pandemic-era surge to post-pandemic decline

32/100 ✓ Peer-reviewed Health systems and care delivery Figshare

Full summary, score breakdown and related studies → Original source

Additional file 1 of Telehealth among Medicare Advantage beneficiaries with and without Alzheimer's Disease and Related Dementias (ADRD), 2018–2024: from pandemic-era surge to post-pandemic decline

41/100 ✓ Peer-reviewed Health systems and care delivery Figshare

Full summary, score breakdown and related studies → Original source

Telehealth among Medicare Advantage beneficiaries with and without Alzheimer's Disease and Related Dementias (ADRD), 2018–2024: from pandemic-era surge to post-pandemic decline

44/100 ✓ Peer-reviewed Health systems and care delivery BMC Health Services Research

Key finding: Among 421,131 MA beneficiaries, telehealth use increased sharply in Q2 2020 for both ADRD and non-ADRD groups, peaking at 33.9 and 30.6% respectively. +4 more findings

• Digital Tools
• Policy

Full summary, score breakdown and related studies → Original source

Risk Adjustment for Alzheimer Disease and Related Dementias in Medicare Advantage and Health Care Experiences

46/100 ✓ Peer-reviewed Health systems and care delivery JAMA Network Open

Key finding: Among 5353 MA beneficiary observations (1239 [23.1%] aged 65-74 years; 3127 [58.4%] aged ≥75 years; 1785 male [33.3%]), 1629 (30.4%) reported a diagnosis of ADRD, and 3724 (69.6%) did not report an ADRD diagnosis. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Study of the utility and impact of a plasma p-tau181 Alzheimer's biomarker (SUITABLE)

49/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia: Translational Research & Clinical Interventions

Key finding: Non-elevated plasma p-tau181 results impacted the diagnosis and use of amyloid PET imaging in a memory clinic. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Music therapy in health care practice: promise, pitfalls, and policy implications

35/100 ✓ Peer-reviewed Health systems and care delivery Frontiers in human neuroscience

Key finding: This review concludes with actionable policy recommendations that are imperative to implementing music-based interventions for person-centered, holistic care and ensuring the sustainability of health care systems in the face of aging populations and rising prevalence of chronic illnesses.

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

Microglia protein profiles in CSF across Alzheimer’s disease clinical stages

51/100 ✓ Peer-reviewed Inflammation and the immune system Nature Aging

Key finding: Microglia are implicated in the progression of Alzheimer's disease (AD) pathology from its earliest stages, suggesting that cerebrospinal fluid (CSF) microglia profiling across clinical AD stages can aid in treatment development and monitoring. +2 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

ALS and Huntington Disease: Unraveling the Connections between TDP-43 and Huntingtin

40/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Neuroscience

Key finding: Though their etiology and pathology are distinct, recent evidence suggests commonalities between TAR DNA-binding protein (TDP-43), which is associated with 97% of ALS cases, and huntingtin (HTT), the causative protein of HD. +2 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Liver–metabolic stress, apolipoprotein E ε4, and cognition and amyloid burden: findings from the dementia platform Korea trial-ready registry

51/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Aging Neuroscience

Key finding: Routine liver–metabolic indices were associated with cognitive performance, while FIB-4 stage showed effect modification by APOE ε4 in relation to both cognition and amyloid PET SUVR. +3 more findings

• Genetics
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Health literacy and urban–rural disparities: a cross-sectional study of access, adherence, and quality of life across the neurological spectrum

52/100 ✓ Peer-reviewed Disparities Frontiers in Public Health

Key finding: One-third of adults with neurological conditions in China have low health literacy, with pronounced socioeconomic and geographic disparities. +3 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Anti‐amyloid antibodies in Europe: Where are we now?

33/100 ✓ Peer-reviewed Treatments British Journal of Clinical Pharmacology

Key finding: In the pivotal study in the overall population, the treatment showed a difference of −0.45 points between lecanemab and placebo in the adjusted mean change from baseline on the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) at 18 months (the primary endpoint). +4 more findings

• Treatments
• Clinical Trials
• Side Effects

Full summary, score breakdown and related studies → Original source

Blood phosphorylated tau elevation as a biomarker in immunoglobulin light chain and transthyretin amyloidosis

51/100 ✓ Peer-reviewed Tau biomarkers Nature medicine

Key finding: Elevated p-tau levels have also been associated with cerebral deposition of Danish amyloid and prion protein amyloid. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Multi-site MRI analysis of morphometric differences in brain regions in the presence of hearing loss and tinnitus across the adult lifespan

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: The impact of age and hearing loss on the brain has garnered significant attention, as both factors have been implicated in the development of cognitive impairment or dementia. +4 more findings

• Risk Factors

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Balancing benefit and risk in early Alzheimer's disease: the European Medicines Agency (EMA) assessment of lecanemab and donanemab

47/100 ✓ Peer-reviewed Treatments The Lancet regional health. Europe

Key finding: Recent regulatory approvals of lecanemab and donanemab in the EU mark a significant milestone. +1 more finding

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Healthcare Utilization Among Older Adults With Dementia in France: A Comparative Analysis of a Dementia Village and Traditional Nursing Homes

51/100 ✓ Peer-reviewed End-of-life care Value in Health

Key finding: VLAHE residents had fewer hospitalizations and shorter stays (10.5 vs 15.2 days, P = .0004) than comparable NH residents, particularly for acute care. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

LDL oxidation and cerebrovascular aging: mechanisms of endothelial dysfunction, inflammation, and vascular cognitive impairment and dementia

43/100 ✓ Peer-reviewed Inflammation and the immune system Redox Biology

Key finding: Epidemiological evidence suggests that aging is associated with modifications in circulating low-density lipoprotein (LDL) and high-density lipoproteins (HDL), particularly oxidation, which further accelerates neurovascular pathology.

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases

39/100 ✓ Peer-reviewed Brain tissue and pathology Communications Biology

Key finding: Together, these findings reveal a critical link between metabolic dysregulation and genomic instability in TDP-43 pathology-associated motor neuron diseases, and underscore therapeutic potential of F2,6BP.

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Understanding the family caregivers’ needs in late-stage dementia: a qualitative perspective to inform policy action

40/100 ✓ Peer-reviewed Brain tissue and pathology BMC Geriatrics

Key finding: Family caregivers had information, psychosocial, and self-care needs that were deeply intertwined and frequently coexisted at the same time. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

TDP-43 pathology triggers neuroinflammation and cognitive impairment by inducing microglial necroptosis

36/100 ✓ Peer-reviewed Brain tissue and pathology EMBO Molecular Medicine

Key finding: In this study, we demonstrated that cytoplasmically mis-localized TDP-43 exacerbated neuroinflammation, induced cell death, and impaired phagocytic function in microglial cells, primarily through receptor interacting serine/threonine kinase 3 (RIPK3)-dependent necroptosis. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Proteinopathy

36/100 ✓ Peer-reviewed Brain tissue and pathology Molecules

Key finding: The cytoplasmic accumulation of TDP-43 aggregates remains a persistent pathological hallmark of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and limbic-predominant age-related TDP-43 encephalopathy (LATE). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma p-tau217 and glucose metabolism correlate in neocortical association areas in Alzheimer's disease

52/100 ✓ Peer-reviewed Biomarkers Brain communications

Key finding: This suggests that, despite the above correlations, imaging provides additional information. +1 more finding

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source