Newest studies

ARTIFICIAL INTELLIGENCE IN THE MANAGEMENT OF AGING-RELATED DISEASES: CURRENT MODELS, LIMITATIONS, AND FUTURE DIRECTIONS

28/100 ✓ Peer-reviewed Digital health tools Anti-Aging Eastern Europe

Key finding: Overall, AI has substantial potential to support more precise, person-centred care for older adults, but realising this promise will require multimorbidity-aware, transparent models, robust evaluation in diverse geriatric populations and governance frameworks that ensure fairness, privacy and meaningful human oversight.

• Digital Tools

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Alzheimer Disease: An Integrated Multidisciplinary Perspective on Pathophysiology, Diagnosis, Management, and Contemporary Therapeutic Advances for Pharmacists, Neurologists, Nurses, Health Information Professionals, and Healthcare Assistants

27/100 ✓ Peer-reviewed Genetics Saudi Journal of Medicine and Public Health

Key finding: Alzheimer disease involves interacting mechanisms that include amyloid-beta accumulation, abnormal tau phosphorylation and aggregation, cholinergic dysfunction, synaptic degeneration, neuronal loss, neuroinflammation, vascular pathology, and genetic susceptibility. +4 more findings

• Treatments
• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

CMS GUIDE Model: Lessons Learned by an Established Track Program at End of Year One

60/100 ✓ Peer-reviewed Caregiving Innovation in Aging

Key finding: 158 beneficiary-caregiver pairs were enrolled in year one; average beneficiary age was 79 +4 more findings

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Budget Impact Analysis of Disease-Modifying Therapies for Alzheimer’s Disease in Ireland: A Model-Based Analysis

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: These therapies require complex diagnostic workup and safety monitoring, raising significant budget impact concerns for healthcare payers. +1 more finding

• Treatments
• Policy

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Lessons Learned from a Pandemic: Personhood and Caregiver Stress in Nursing Home Dementia Care

25/100 ✓ Peer-reviewed Health systems and care delivery Journal of Aging and Long-Term Care

Key finding: Biologic personhood declined through missed care, appetite loss, diminished grooming, and behavioral signs of distress. +4 more findings

• Care Services
• Caregiving

Full summary, score breakdown and related studies → Original source

Developing and Testing a Program to Strengthen the Dementia Palliative Care Trial Workforce

49/100 ✓ Peer-reviewed End-of-life care Journal of Pain and Symptom Management

Key finding: Three cohorts of interdisciplinary scholars (N = 53) have started and two have completed DEM-PCCT. +4 more findings

• End-of-Life Care
• Clinical Trials

Full summary, score breakdown and related studies → Original source

ICF Application and Assessment Tool Analysis for Dysphagia Evaluation in Patients with Dementia: A Scoping Review

32/100 ✓ Peer-reviewed Clinical safety Journal of the Korean Dysphagia Society

Key finding: Instrumental assessments (Videofluoroscopic Swallowing Study [VFSS], Fiberoptic Endoscopic Evaluation of Swallowing [FEES]) and the Water Swallow Test were most frequently used.ICF mapping revealed that 96.7% of tools focused on body functions, while only approximately 20% addressed participation and environmental factors. +1 more finding

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Associations between joint air pollution exposure, mental health, and physical health and dementia incidence in an aging U.S. cohort

39/100 ✓ Peer-reviewed How common it is The Journals of Gerontology Series B

Key finding: We found significant associations between ADRD risk and particulate matter <2.5 µm in diameter and nitrogen dioxide in women. +4 more findings

• Risk Factors

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Application of Convolutional Neural Network Based on ResNet18 for Alzheimer Disease Classification

28/100 ✓ Peer-reviewed Brain scans and imaging International Journal of Artificial Intelligence Research

Key finding: Alzheimer's disease is a form of progressive dementia that significantly impacts the quality of life of patients and their families. +2 more findings

• Brain Scans
• Digital Tools

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Klasifikasi Penyakit Alzheimer menggunakan CNN dengan pretrained VGG19 dan SMOTE berdasarkan Citra MRI Otak

28/100 ✓ Peer-reviewed Brain scans and imaging Arcitech Journal of Computer Science and Artificial Intelligence

Key finding: The evaluation results show that the classification accuracy reaches 95%, higher than previous studies using VGG-19 with an accuracy of 77.66%. +1 more finding

• Brain Scans

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Cardiovascular Risk as a Moderator of the Relationship Between Plasma Alzheimer Disease Biomarkers and Cognitive Status

50/100 ✓ Peer-reviewed Tau biomarkers Journal of the American Heart Association

Key finding: Plasma biomarkers may aid Alzheimer disease (AD) diagnosis and prognosis. +3 more findings

• Biomarkers
• Risk Factors

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Acoustic Analysis of Primary Care Patient-provider Conversations to Screen for Cognitive Impairment

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: The mean age was 66.8 years and 21% had CI. +4 more findings

• Care Services

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Large Language Model-Driven Prioritization of Alzheimer’s Disease Drug Targets Across Multidimensional Criteria

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: Together, these results demonstrate that retrieval-augmented LLMs, when combined with structured comparative prompting and multi-criteria integration, can approximate expert-level reasoning and meaningfully enrich target prioritization pipelines for AD.

• Treatments

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

NAD+ restores proteostasis through splicing-dependent autophagy

45/100 ✓ Peer-reviewed Disease mechanisms Autophagy

Key finding: Cross-species analyses in C. elegans, mice, and human samples reveal that NAD+ supplementation corrects hundreds of age- or Alzheimer-associated splicing errors, notably restoring balanced expression of EVA1C isoforms. +4 more findings

• Brain Biology

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Association of Plasma GFAP and NfL in Middle-Aged Adults With MRI Markers of Cerebral Small Vessel Disease Later in Life

50/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: NfL was not significantly associated with any MRI cSVD marker. +4 more findings

• Biomarkers
• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Inflammation as a mediator of air pollution's role in Alzheimer's disease and related dementias

43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease

Key finding: Long-term PM exposure, particularly PM 10 , may contribute to increased AD/ADRD susceptibility, potentially through inflammation-related pathways. +2 more findings

• Risk Factors
• Diagnosis
• Brain Biology

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Thirty-seven-year trends in the prevalence, incidence, and prognosis of dementia in a Japanese community: the Hisayama study

49/100 ✓ Peer-reviewed How common it is Alzheimer s Research & Therapy

Key finding: The crude prevalence of dementia significantly increased from 1985 to 2012 (6.7% in 1985, 5.7% in 1992, 7.1% in 1998, 12.5% in 2005, and 17.9% in 2012, p for trend < 0.01), but then decreased significantly from 2012 to 2022 (15.8% in 2017 and 12.1% in 2022; p for trend < 0.01). +4 more findings

• Risk Factors

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Association Between Circadian Rest-Activity Rhythms and Incident Dementia in Older Adults

60/100 ✓ Peer-reviewed Disparities Neurology

Key finding: Of the 2,183 participants (mean ± SD age 79 ± 4.5 years, 58% female, 24% Black), 176 (8%) developed dementia. +4 more findings

• Risk Factors

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LINE-1 retrotransposition in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and cell non-autonomous programmed cell death

40/100 ✓ Peer-reviewed Risk factors PLoS Genetics

Key finding: A causal role of RTEs/ERVs has been demonstrated in Drosophila in mediating both intracellular toxicity of TDP-43 and the intercellular spread of toxicity from glia to neurons. +2 more findings

• Brain Biology

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Exploring cellular heterogeneity: single-cell and spatial transcriptomics of Alzheimer's disease brains and iPSC-derived microglia

43/100 ✓ Peer-reviewed Genetics Alzheimer's research & therapy

Key finding: Our comprehensive atlas revealed pronounced heterogeneity among microglial states, with disease-associated microglia (DAM) significantly enriched in AD brains compared to controls. +4 more findings

• Brain Biology

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Digital health interventions for urinary tract infection prevention and management in people living with dementia and their family caregivers: a scoping review

51/100 ✓ Peer-reviewed Digital health tools The Gerontologist

Key finding: Seven studies were included from 1,800 screened. +4 more findings

• Digital Tools
• Caregiving

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Night-to-night REM sleep variability: a relevant marker of early amyloid-β deposition

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

Key finding: Shorter sleep duration and greater REM sleep variability may index early AD-related brain changes, warranting longitudinal studies to establish their prognostic significance. +1 more finding

• Clinical Trials
• Lifestyle

Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Activation of neurogenesis improves amyloid-β pathology and cognitive function through AMP kinase signaling in Alzheimer’s disease model mice

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Cell reports

Key finding: We previously demonstrated that a treatment of inducing Plagl2 , a zinc finger transcription factor gene, and antagonizing Dyrk1a , a gene associated with Down syndrome, referred to as iPaD, can functionally rejuvenate aged neural stem cells (NSCs), thereby enhancing neurogenesis and improving cognition in aged mice. +4 more findings

• Brain Biology

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Oxidative Stress as a Central Mechanistic Bridge Between Alzheimer’s and Vascular Pathologies in Mixed Dementia: Emerging Evidence and Therapeutic Perspectives

39/100 ✓ Peer-reviewed Inflammation and the immune system Biomedicines

Key finding: Mechanistic models demonstrate how chronic hypoperfusion and mitochondrial dysfunction exacerbate ROS generation and neuroinflammation, while impaired Nrf2-mediated antioxidant defense further amplifies damage. +4 more findings

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Correlation of White Matter Lesions, Cerebral Blood Flow, and Cognitive Decline in Patients With Alzheimer’s Disease and Vascular Dementia

44/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of Clinical Neuropsychology

Key finding: Compared to controls, the AD/VaD patient group had a significantly higher WML volume (p < .001), reduced global CBF (p < .001), greater brain atrophy, and worse ADAS-Cog scores (p < .001). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source