Newest studies

Investigating the Amyloid-Tau-Neurodegeneration Framework in Alzheimer’s Disease Using Semi-Supervised Multimodal Imaging Data Fusion

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

Key finding: Semi-supervised multimodal fusion improves prediction and reveals interpretable imaging patterns that predict APOE4 and clinical diagnoses better than traditional approaches. +1 more finding

• Brain Scans
• Biomarkers

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Real-world experience with baseline characteristics and safety of lecanemab for Alzheimer's disease in Eastern China

59/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

Key finding: Logistic regression for distinguishing early AD from the Aβ negative cognitively unimpaired populations showed that p-Tau 217 independently provided better classification efficacy (area under the curve = 0.9983, p < 0.0001). +2 more findings

• Treatments
• Side Effects
• Diagnosis

Full summary, score breakdown and related studies → Original source

Effectiveness of acetylcholinesterase inhibitors and memantine in patients affected by severe dementia

42/100 ✓ Peer-reviewed Treatments GeroScience

Key finding: Overall, 703 patients (mean age:78.3 ± 7.2 years; females:56.1%) with severe dementia (Mini-Mental State Examination-MMSE ≤ 10/30) were included [407 late-onset Alzheimer's disease (LOAD), 126 Lewy body dementia (LBD), 170 vascular dementia (VD)]. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Nutritional strategies against dementia in rural populations

31/100 ✓ Peer-reviewed Disparities Frontiers in Nutrition

Key finding: The burden of dementia is high in rural communities, where access to healthcare services, nutritional resources, and educational opportunities is significantly limited. +2 more findings

• Health Equity
• Lifestyle
• Brain Biology

Full summary, score breakdown and related studies → Original source

Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clinical Mismatch

61/100 ✓ Peer-reviewed Biomarkers JAMA Neurology

Key finding: A total of 365 participants (mean [SD] age, 75.4 [7.9] years; 192 female [52.6%]) in the ADNI tau-PET group and 524 participants (mean [SD] age, 77.1 [7.9] years; 268 male [51.1%]) in the ADNI p-tau217 group were selected from the 998 individuals who were Aβ+ in the ADNI cohort and used to generate tau-clinical mismatch models with 55.6% to 57.1% classified as canonical (CDR-SB commensurate to tau), 23.7% to 24.7% as resilient (CDR-SB < tau), and 19.3% to 19.7% as vulnerable (CDR-SB > tau). +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Persistent Functional Impairment as an Early Indicator of Alzheimer Disease Pathology and Progression

55/100 ✓ Peer-reviewed Tau biomarkers Journal of the American Geriatrics Society

Key finding: Functional impairment (FI) is a key criterion for diagnosing dementia. +3 more findings

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Specific midlife depressive symptoms and long-term dementia risk: a 23-year UK prospective cohort study

60/100 ✓ Peer-reviewed Prevention and risk Lancet Psychiatry

Key finding: A distinct set of midlife depressive symptoms was associated with an increased risk of dementia, suggesting that these symptoms might be early markers of underlying neurodegenerative processes. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease

43/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

Key finding: We demonstrate that the small-molecule TREM2 ligand SULF A functions as an immunomodulator that reprograms microglia toward a reparative phenotype. +4 more findings

• Brain Biology

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NIA perspective on harmonizing International Health and Retirement Studies (HRS) and Harmonized Cognitive Assessment Protocol (HCAP) studies

45/100 ✓ Peer-reviewed Getting a diagnosis The Journals of Gerontology Series B

Key finding: The NIA hopes to see continued collection and harmonization of the International HRS and HCAP data, as well as continued use of the data to advance our knowledge of how behavioral and social factors influence aging and life course outcomes, including those related to AD/ADRD. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment

69/100 ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy

Key finding: Both intervention and control groups showed cognitive improvement over 24 weeks, with greater gains in the intervention arm. +4 more findings

• Genetics
• Early Stage

Full summary, score breakdown and related studies → Original source

Mirtazapine for gastrointestinal side effects of glucagon-like peptide-1 receptor agonist therapy in older adults

48/100 ✓ Peer-reviewed Drug development Endocrine regulations

Key finding: This case suggests that mirtazapine may be beneficial in mitigating GLP-1 RA-induced gastrointestinal side effects, thereby improving adherence and therapeutic efficacy. +3 more findings

• Treatments
• Side Effects
• Risk Factors

Full summary, score breakdown and related studies → Original source

Luteolin in Safflower Leaves Suppresses Microglial Inflammation Through FOXO3-Mediated Trem2 Transcription

43/100 ✓ Peer-reviewed TREM2 and immune genetics Antioxidants (Basel, Switzerland)

Key finding: Here, we demonstrated that safflower leaves inhibit microglial inflammation and upregulate TREM2 in APP/PS1 mice. +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Impact of multidomain lifestyle intervention on dynamics of cognitive frailty: post hoc analysis of the FINGER trial

49/100 ✓ Peer-reviewed Prevention trials The Journals of Gerontology Series A

Key finding: At baseline, 219 participants (18%) had CF. +4 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support

44/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroinflammation

Key finding: As these mitochondrial features are related to the acquisition of cell senescence, we evaluated this at the transcriptome level and found that these AD-derived astrocytes significantly upregulated gene signatures of cellular senescence and displayed a senescence-associated secretory phenotype (SASP). +2 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study

42/100 ✓ Peer-reviewed Long-term cohort studies Diabetes Obesity and Metabolism

Key finding: In UKB, higher 2-h post-load glucose was associated with a 69% increased Alzheimer's dementia risk (odds ratio 1.69 [95% confidence interval 1.38-2.07]), though this did not replicate in an independent GWAS. +4 more findings

Full summary, score breakdown and related studies → Original source

Análogos do glp-1 na doença de alzheimer: potencial neuroprotetor além do controle glicêmico uma revisão narrativa

27/100 ✓ Peer-reviewed Tau biomarkers DELOS Desarrollo Local Sostenible

Key finding: A síntese foi organizada em quatro eixos: plausibilidade fisiopatológica, evidência experimental, evidência clínica e segurança. +4 more findings

• Biomarkers

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Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group

40/100 ✓ Peer-reviewed Lewy body dementia Communications Medicine

Key finding: Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Innovations in Dementia Empowerment and Action: RCT for Underserved Communities

53/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: The cultural tailoring of interventions is promising to address disparities in dementia care and interventions in underserved communities. +3 more findings

• Health Equity
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Periodontitis and incident cognitive decline and dementia: A 15-year prospective cohort study of older men residing in Northern Ireland

52/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer s Disease

Key finding: We also assessed associations between exposure to periodontal pathogens and blood inflammatory markers. +3 more findings

• Early Stage

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Impact of rheumatoid arthritis on Alzheimer’s disease: A two-sample bidirectional Mendelian randomization study

37/100 ✓ Peer-reviewed Genetics Medicine

Key finding: Further sensitivity analyses were conducted using leave-one-out method and funnel plots, to evaluate the robustness of the results. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Cost-effectiveness of testing biofluid biomarkers to diagnose Alzheimer's disease: a systematic review

48/100 ✓ Peer-reviewed Costs and economics European Journal of Health Economics

Key finding: Our review supports that biofluid biomarker testing could be cost-effective to diagnose AD. +1 more finding

• Policy
• Biomarkers

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The effects of vortioxetine versus placebo on cognitive functioning in mild cognitive impairment: a placebo-controlled, randomized, double-blind study

16/100 ⚠ Preprint — not yet peer-reviewed Clinical trials medRxiv

Key finding: In a recent open-label, single-arm study, vortioxetine, an antidepressant, was associated with improved cognitive function in patients with MCI, however, no placebo-controlled studies have been conducted to support these findings. +4 more findings

• Clinical Trials
• Early Stage

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Distinct cerebrovascular pathways underlying Alzheimer's disease-related neurodegeneration

54/100 ✓ Peer-reviewed Vascular contributions Acta neuropathologica

Key finding: More severe CAA was also explained by cortical atrophy and AD pathology (β = 0.6, 95% CI 0.2 to 1.2, p = 0.007), and associated with poorer memory (β = - 0.2, 95% CI - 0.3 to -0.09, p = 0.0009). +2 more findings

• Treatments
• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Environmental Factors and Risk of Early-Onset Dementia: A Population-Based Case-Control Study

57/100 ✓ Peer-reviewed Risk factors Neuroepidemiology

Key finding: Green spaces generally showed an inverse association with EOD risk that was almost linear for AD and inverted U-shaped for non-AD. +4 more findings

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Plasma NfL, GFAP, and pTau181 in patients with isolated REM sleep behavior disorder

61/100 ✓ Peer-reviewed Biomarkers Sleep

Key finding: The study included 44 iRBD patients (81.8% males, mean age 71.0 ± 6.4 years), 55 HC (66.3% males, mean age 69.1 ± 5.5 years), and 28 AD patients (82.1% males, mean age of 70.4 ± 6.7 years). iRBD patients showed significantly higher plasma NfL and GFAP levels and similar pTau181 levels compared to HC. +4 more findings

• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source