Newest studies

Decoding TREM2 Signaling Pathways

48/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology Neuroimmunology & Neuroinflammation

Key finding: Loss-of-function sequence variants, such as R47H, disrupt lipid metabolism, impair phagocytic activity, and destabilize immune homeostasis, thereby significantly increasing disease susceptibility.

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

EEG-based classification of alzheimer’s disease and frontotemporal dementia using functional connectivity

52/100 ✓ Peer-reviewed Lewy body dementia Scientific Reports

Key finding: Overall, these findings highlight the potential of EEG connectivity features for dementia classification and emphasize the importance of careful feature engineering and low-complexity models in the case of small-sample datasets.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Obesity and Cancer: Mechanisms, Epidemiological Evidence, and Potential Risk Reduction

58/100 ✓ Peer-reviewed Prevention and risk Journal of Obesity & Metabolic Syndrome

Key finding: We also review prevention data: observational studies and select trials suggest that intentional weight loss-via lifestyle interventions, pharmacotherapy (including glucagon-like peptide-1 receptor agonists), or bariatric surgery-can reduce overall or site-specific cancer incidence, although estimates are heterogeneous and causal certainty is limited. +1 more finding

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Blood biomarkers of frailty and cognition: A scoping review

42/100 ✓ Peer-reviewed Biomarkers Neurobiology of Aging

Key finding: Five of the 76 unique biomarkers identified —A disintegrin and Metalloproteinase 10 (ADAM10), fibrinogen, interleukin (IL)-6, neurofilament light chain (NfL) and vitamin D— were significantly and independently associated with both frailty and cognition.

• Biomarkers

Full summary, score breakdown and related studies → Original source

The Societal Cost of Alzheimer’s Disease depends on the Diagnosis Timing

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: Earlier diagnosis increases total expenditures but improves care and cost allocation.

• Policy
• Diagnosis

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

CSF proteomics of semorinemab Alzheimer's disease trials identifies cell-type specific signatures

84/100 ✓ Peer-reviewed Drug development Brain : a journal of neurology

Key finding: However, semorinemab was associated with a significant slowing in progression in a co-primary end point of cognition only in Lauriet but not in Tauriel. +4 more findings

• Clinical Trials
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

The Lifestyle Intervention in memory clinics of General and academic Hospitals Trial (LIGHT): Rationale and study design of a randomized controlled trial to reduce modifiable dementia risk

55/100 ✓ Peer-reviewed Prevention trials Alzheimer s Research & Therapy

Key finding: LIGHT will provide insight into the implementation and (cost-)effectiveness of a lifestyle intervention for indicated prevention in a memory clinic setting. +1 more finding

• Clinical Trials
• Prevention
• Care Services

Full summary, score breakdown and related studies → Original source

Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer’s disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort

55/100 ✓ Peer-reviewed Mild cognitive impairment The Journal of Prevention of Alzheimer s Disease

Key finding: Low baseline Aβ42/Aβ40 was significantly associated with increased amyloid accumulation (β = 0.257, 95% confidence interval (CI) 0.177-0.336, P < 0.001), and with higher risk of conversion to Aβ-PET positivity (Hazard ratio (HR) = 2.84, 95% CI 1.14-7.04, P = 0.025) and to MCI due to AD (HR = 3.25, 95% CI 1.17-9.01, P = 0.024). +4 more findings

• Early Stage
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes

39/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging Neuroscience

Key finding: We found interactions between APOE4 and cognitive states in the aperiodic EEG exponent and the spectral power ratio (SPR). +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Incidence of dementia diagnosis in Denmark, 1986–2023: an age-period-cohort analysis

40/100 ✓ Peer-reviewed How common it is Social Science & Medicine

Key finding: Younger cohorts showed lower dementia incidence rates compared to older cohorts at similar ages, likely due to changes to modifiable risk factors.

• Risk Factors
• Diagnosis

Full summary, score breakdown and related studies → Original source

Intervention Without Borders - an Automated Self-Guided AI-Enhanced Psychoeducation Intervention for Dementia Caregivers: Parallel-Group Randomized Waitlist-Controlled Trial

60/100 ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: The effects on depression and other outcomes were consistent with those observed for in-person programs, suggesting the viability of well-designed automated intervention. +1 more finding

• Clinical Trials
• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer’s disease by chemically distinct air pollutants

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: Air pollution (AirP) exposure is associated with increased Alzheimer’s disease (AD) risk, yet AirP is chemically heterogeneous, complicating identification of shared pathogenic drivers. +1 more finding

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice

39/100 ✓ Peer-reviewed Inflammation and the immune system Science Translational Medicine

Key finding: These findings suggest that a durable yet modest restoration of PGRN expression in the CNS is sufficient to correct pathology.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Altered temporal dynamics of prefrontal ERP responses reflecting neural adaptation in patients with amnestic mild cognitive impairment

43/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s Research & Therapy

Key finding: Event-related potentials (ERPs), particularly the P200 component, have been studied as potential biomarkers, but conventional grand-averaged approaches often yield inconsistent results. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Assessing the Impact of Sociodemographic Factors on Artificial Intelligence Models in Predicting Dementia: Retrospective Cohort Study

45/100 ✓ Peer-reviewed Risk factors JMIR Medical Informatics

Key finding: Across both cohorts, individuals with lower SES generally exhibited higher BERs (worse performance) than high SES groups, confirming the presence of bias. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Evaluation of [18F]MK-6240 binding to tau protein in postmortem human brains of Down syndrome and Alzheimer’s disease and assessment of off-target (non-tau) binding

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: Our findings suggest [ 18 F]MK-6240 to be selective tau imaging agent in DSAD and AD, harmine to be a weak tau drug, and off-target nonspecific meninges binding maybe due to the primary aromatic amine group in [ 18 F]MK-6240.

• Brain Biology
• Down Syndrome

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

ATN Classification and Machine-Learned Plasma Biomarker Phenotypes Reveal Distinct Alzheimer’s Pathology in a Population-Based Cohort

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: The analytic sample included 4,465 individuals (mean age 69.7±10.4 years; 58.7% female; 75.8% non-Hispanic White). +3 more findings

• Biomarkers

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Current and Emerging Therapeutic Approaches for Vascular Cognitive Impairment and Dementia

45/100 ✓ Peer-reviewed Risk factors Journal of the American College of Cardiology

Key finding: VCID treatment developments have been slow compared with Alzheimer's disease (AD), which now has several FDA-approved symptom- and disease-modifying agents.

• Treatments
• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Phase 3 randomized clinical trials of simufilam in mild-to-moderate Alzheimer's disease

58/100 ✓ Peer-reviewed Inflammation and the immune system The journal of prevention of Alzheimer's disease

Key finding: Simufilam did not meet co-primary or secondary endpoints in these Phase 3 trials. +2 more findings

• Clinical Trials
• Brain Biology
• Diagnosis

Full summary, score breakdown and related studies → Original source

A multimodal sleep foundation model for disease prediction

64/100 ✓ Peer-reviewed Risk factors Nature Medicine

Key finding: Sleep is a fundamental biological process with broad implications for physical and mental health, yet its complex relationship with disease remains poorly understood. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Digital biomarkers in early Alzheimer's disease from wearable or portable technology: A scoping review

49/100 ✓ Peer-reviewed Digital health tools Journal of the Neurological Sciences

Key finding: After deduplication and screening of 8893 records, we included 109 studies describing a wide array of wearable or portable DHTs that obtained digital biomarkers. +4 more findings

• Digital Tools
• Biomarkers

Full summary, score breakdown and related studies → Original source

Exponential random graph-based eXplainable Artificial Intelligence for Alzheimer disease

32/100 ✓ Peer-reviewed Brain scans and imaging Physical review. E

Key finding: The use of statistical physics models to investigate real-world networks and reveal their underlying dynamics has shown promising results and acquired increasing attention. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Polygenic risk for white matter hyperintensities is associated with early cerebrovascular events partly through hemodynamic measures in cognitively unimpaired middle-aged and older adults with low cardiovascular risk

46/100 ✓ Peer-reviewed Vascular contributions Frontiers in Neurology

Key finding: They are often found in middle-aged individuals and are associated with a greater risk of stroke and vascular dementia. +4 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

In Vitro and In Vivo Evaluation of Small-Molecule Disassemblers of Pathological Tau Fibrils

41/100 ✓ Peer-reviewed Disease mechanisms ACS Chemical Neuroscience

Key finding: Thus, reversing tau aggregation is a potential therapeutic avenue for AD. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Charting the research frontier for viral infections, immunomodulation, and dementia: a perspective on synaptic biomarkers as essential clinical trial endpoints

55/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Cellular and Infection Microbiology

Key finding: The paradoxical trial results may arise from omitting these synaptic measures, creating a mechanistic "black box" obscuring their true biological effects.

• Clinical Trials
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source