Newest studies

Monoclonal antibodies for treatment Alzheimer`s disease

44/100 ✓ Peer-reviewed Treatments Reports of Vinnytsia National Medical University

Key finding: The reviewed evidence indicates that mAbs can reduce amyloid plaques and tau aggregates, thereby slowing cognitive decline, particularly in early stages of AD. +2 more findings

• Treatments
• Clinical Trials
• Side Effects

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Safety of Lecanemab After 6‐Month Treatment in the DIAN‐TU‐001 Trial

49/100 ✓ Peer-reviewed Treatments Alzheimer s & Dementia

Key finding: Lecanemab was generally well-tolerated during the 6-month lecanemab-only treatment period. +4 more findings

• Treatments
• Side Effects

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How to efficiently move towards primary prevention in sporadic AD

49/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: The findings from the AHEAD Study screening process and longitudinal data from the LEARN Study are providing critical data to guide future prevention trial design. +4 more findings

• Prevention
• Health Equity

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CSF sTREM2 is associated with distinct microglial responses with separate effects on Alzheimer's pathology in the disease's trajectory

39/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: There is significant evidence that microglia contribute to neuroinflammation and neurotoxicity in AD 1,2 , yet there is also evidence to the contrary. +4 more findings

• Brain Biology

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Application of supervised and unsupervised machine learning approaches to identify somatic T‐cell receptor sequence variation in Alzheimer disease among Midwestern Amish

37/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Participants did not differ significantly based on sex. +4 more findings

• Genetics

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Genetic Colocalization of Expression Quantitative Trait Loci (eQTL) Mapping and GWAS in a multiethnic brain bank: An Insight into ancestry‐specific Regulatory Architecture in Alzheimer's disease

33/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: In the colocalization of cis-eQTL and GWAS signals for Hispanics, we observed a high posterior probability (posterior prob = 0.9947) for the upstream gene variant rs755980338 on chromosome 11, which locally regulates EHD1 gene (GWAS p-value = 0.009, cis-eQTL p-value = 0.0041). +4 more findings

• Genetics
• Policy

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Aplicaciones de la genética clínica en el diagnóstico y pronóstico de Alzheimer: una revisión actualizada

27/100 ✓ Peer-reviewed Genetics Polo del Conocimiento

Key finding: La integración de pruebas genéticas y moleculares, como la identificación de variantes en los genes APOE, APP, PSEN1 y PSEN2, así como el uso de biomarcadores en plasma y líquido cefalorraquídeo, ha demostrado mejorar de manera significativa la precisión diagnóstica y la capacidad de anticipar la progresión clínica. +4 more findings

• Genetics

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APOE‐Genotype Modifies the Association of Meat Consumption with Cognitive Decline: Longitudinal Analyses of The Swedish National Study on Aging and Care, SNAC‐K

42/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Higher total meat consumption (red meat: 51%, poultry: 20%, processed meat: 29%), was associated with a better cognitive trajectory only in the APOE34/44 stratum (β per 1 z-unit increase: 0.011; CI: 0.004 to 0.018 versus -0.003; CI: -0.008 to 0.003; P for interaction = 0.002). +4 more findings

• Genetics

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Elevated CSF levels of matrix metalloproteinase‐12 as a potential marker for microhemorrhage risk in autosomal dominant Alzheimer disease

34/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Eight proteins were differently expressed in carriers with larger WMH volumes (Figure 1). +4 more findings

• Genetics
• Biomarkers

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Elevated CSF levels of matrix metalloproteinase‐12 as a potential marker for microhemorrhage risk in autosomal dominant Alzheimer disease

31/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Eight proteins were differently expressed in carriers with larger WMH volumes (Figure 1). +4 more findings

• Genetics
• Biomarkers

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Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration

44/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Analysis of the genotyping data revealed that the TMEM106B locus consists of four major haplotypes: HA/Ha (covering the coding region), and HB/Hb (covering the upstream regulatory region). +4 more findings

• Genetics

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Lecanemab, aducanumab, and donanemab bind the same human Alzheimer disease Aβ aggregates at different epitopes

36/100 ✓ Peer-reviewed Treatments Alzheimer s & Dementia

Key finding: Within the limitations of measuring in vitro equilibrium binding activity of in‐house recombinant antibodies to aqueously extracted Aβ from human postmortem brain tissue, we could not discern a population of Aβ aggregates ( e.g . protofibrils) accessible to one antibody but not the other two. +2 more findings

• Treatments
• Brain Biology

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Alzheimer‐related neuropathology is improved by treatment with longevity‐enhancing treatments in aged male EFAD mice

37/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Both 17αE2 and FMD independently reduced AD neuropathology in the EFAD mice, in an APOE-dependent manner. +4 more findings

• Brain Biology
• Genetics
• Treatments

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Identification of genetic modifiers influencing disease risk in autosomal dominant Alzheimer disease mutation carriers

40/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Finally, at the RHOJ locus, the rare allele was associated with increased tTau ( p ‐value=4.74×10 ‐05 ) and pTau181 ( p ‐value=4.07×10 ‐07 ), and decreased Aβ42/40 ratio ( p ‐value=4.32×10 ‐05 ). +1 more finding

• Genetics

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Evidence of recent natural selection at Alzheimer Disease risk loci and implications for precision medicine

42/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Of the 75 LOAD associated loci, 52 had at least one variant in the top1% of |nSL| in two populations from the 1000 Genomes data. +4 more findings

• Health Equity

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Novel early‐onset Alzheimer‐associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways

38/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Alzheimer Disease (AD) is a highly polygenic dementia that presents with relatively earlier onset (≤65yo; EOAD) in about 5% of cases. +1 more finding

• Genetics

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Heterogeneity in the Genetic Architecture of Alzheimer disease (AD) across Ancestry Groups

40/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Overall SNP‐based heritability estimates using this restricted set of variants varied: AA ( h 2 = 0.13, SE=0.05), NHW ( h 2 = 0.14, SE=0.01), AsA ( h 2 = 0.29, SE=0.09) and HL ( h 2 = 0.48, SE=0.17). +1 more finding

• Genetics

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Leveraging African Ancestry Diversity for Global Advances in Alzheimer Disease Genetics

33/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Our findings highlight the potential of diverse genomic backgrounds to uncover protective genetic factors, such as the African-specific protective PSG2 locus, found to confer a protective effect among APOE4 carriers.

• Genetics

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Investigating the effects of complement loci CFH and ARMS2/HTRA1 on Alzheimer Disease

37/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Our preliminary results found no significant association between LOAD and the individual SNPs defining the CFH or ARMS2/HTRA1 loci. +3 more findings

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Declining to learn results of research biomarker tests for Alzheimer Disease

49/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: 274 participants [average age 75.9 (SD 5.8); 57% women; 13% self-identified as Black] were offered their research results and 40% declined. +4 more findings

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Multimorbidity, Cognition, and Alzheimer Disease Biomarkers: A Pathway Analysis

37/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: After adjusting for age, sex, race/ethnicity, education, APOE ε4, and physical activity, a greater multimorbidity burden (per 3 additional conditions) was associated with worse overall cognition (standardized β = -0.074, 95%CI -0.104 to -0.043) and biomarkers indicative of greater AD pathology, neurodegeneration, and SVD (Figure 1). +4 more findings

• Biomarkers

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Tau is associated with atrophy in MCI independently of beta‐amyloid and APOE e4 genotype

41/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: The first SVD component accounted for 21.56%, 12.93%, 11.91% of the total co-variability between the pairs (cortical thickness, tau), (relative GM density, tau) and (absolute GM density, tau), respectively. +4 more findings

• Genetics
• Early Stage

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Peruvian Population Empowers Discovery of a TREM2 Missense Variant in Alzheimer Disease

39/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Peruvian GWAS identified Amerindian ancestry specific exonic AD susceptibility variant p.H157Y. This variant has been previously reported as AD marker in Han Chinese populations with extreme effect size, but its rarity and contradictory findings in other groups suggest a potential ancestry‐specific effect. +3 more findings

• Genetics

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Significant association between SCN8A and Alzheimer disease in Puerto Ricans

54/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: ) within the first intron of SCN8A on chromosome 12 (Figure 1), overlapping a significant region in the previous admixture mapping analysis. eHiCA revealed more and stronger interactions between rs4761988 and SLC4A8, SCN8A and FIGNL2 in EU compared to AF genome (Figure 2), consistent with the admixture mapping result. +3 more findings

• Genetics

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Microglia‐specific Alzheimer's disease polygenic risk score predicts longitudinal increase in plasma tau and faster cognitive decline in cognitively unimpaired older adults

49/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: We included 1179 CU subjects (n = 474 females (40%), 70.9 ± 4.5 years old) of European descent who had pTau217 and PACC. +4 more findings

• Genetics
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source