Newest studies

A summary risk score for the prediction of Alzheimer disease in elderly persons

56/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: This risk score could be used to identify persons at risk of LOAD, but can also be used to adjust for confounders in epidemiologic studies. +1 more finding

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Depressive symptoms and risk of dementia: the Framingham Heart Study

62/100 ✓ Peer-reviewed Genetics Neurology

Key finding: During the 17-year follow-up period, 164 participants developed dementia; 136 of these cases were AD. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Measuring cognitive reserve based on the decomposition of episodic memory variance

59/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

Key finding: Among the multiple determinants of late-life cognitive course, cognitive reserve has been proposed as an important factor that modifies or buffers the impact of brain pathology on cognitive function. +3 more findings

Full summary, score breakdown and related studies → Original source

Comparing predictors of conversion and decline in mild cognitive impairment

72/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Patients with MCI converted to AD at an annual rate of 17.2%. +1 more finding

• Early Stage
• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

36/100 ✓ Peer-reviewed Disease mechanisms Experimental neurology

Key finding: Parkinson's disease (PD), a progressive neurodegenerative disease, results in abnormal accumulation of insoluble alpha-synuclein (alpha-Syn) in dopaminergic neurons. +1 more finding

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Alzheimer's pathology in primary progressive aphasia

45/100 ✓ Peer-reviewed Digital health tools Neurobiology of aging

Key finding: Of these subtypes, LPA is most commonly associated with Alzheimer's disease (AD) pathology. +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Mild traumatic brain injury: a risk factor for neurodegeneration

56/100 ✓ Peer-reviewed Prevention and risk Alzheimer's research & therapy

Key finding: Although the medical literature also implicates head trauma as a risk factor for Alzheimer's disease, these findings are predominantly based on clinical diagnostic criteria that lack specificity.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study

45/100 ✓ Peer-reviewed Long-term cohort studies Stroke

Key finding: Cerebral atrophy, detected as ventricular enlargement or sulcal widening on MRI, is recognized as a risk factor for vascular dementia or Alzheimer disease. +3 more findings

Full summary, score breakdown and related studies → Original source

Microglial immunoreceptor tyrosine-based activation and inhibition motif signaling in neuroinflammation

41/100 ✓ Peer-reviewed TREM2 and immune genetics International journal of Alzheimer's disease

Key finding: In the mammalian central nervous system, essential molecules in this process are the Fc receptors and the DAP12-associated receptors which both trigger the microglial immunoreceptor tyrosine-based activation motif- (ITAM-) Syk-signaling cascade. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis

57/100 ✓ Peer-reviewed Hippocampus size on brain scans Progress in neuro-psychopharmacology & biological psychiatry

Key finding: Trauma exposure itself in the absence of posttraumatic stress disorder (PTSD) may be associated with hippocampal volume deficits. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics

51/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neurology, neurosurgery, and psychiatry

Key finding: Executive predominant AD may reflect an alternative underlying pathophysiology related to genetic status, reflected in more prominent pathological alterations in frontoparietal regions subserving executive function. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia

53/100 ✓ Peer-reviewed Lewy body dementia Acta neuropathologica

Key finding: Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are usually associated with loss of dopaminergic neurons. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

A generative model for image segmentation based on label fusion

45/100 ✓ Peer-reviewed Hippocampus size on brain scans IEEE transactions on medical imaging

Key finding: Our results indicate that the proposed framework yields more accurate segmentation than FreeSurfer and previous label fusion algorithms.

• Brain Scans

Full summary, score breakdown and related studies → Original source

The BELFRAIL (BFC80+) study: a population-based prospective cohort study of the very elderly in Belgium

64/100 ✓ Peer-reviewed End-of-life care BMC geriatrics

Key finding: The BFC80+ was designed to acquire a better understanding of the epidemiology and pathophysiology of chronic diseases in the very elderly and to study the dynamic interaction between health, frailty and disability in a multi-system approach. +4 more findings

Full summary, score breakdown and related studies → Original source

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

54/100 ✓ Peer-reviewed Vascular contributions The Lancet Neurology

Key finding: Age-related and hypertension-related small vessel diseases and cerebral amyloid angiopathy are the most common forms. +2 more findings

• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Seoul Neuropsychological Screening Battery-dementia version (SNSB-D): a useful tool for assessing and monitoring cognitive impairments in dementia patients

53/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Korean medical science

Key finding: However, it may be a bit too lengthy for patients with decreased attention span; and it does not provide the score of global cognitive function (GCF), which is useful for monitoring patients longitudinally. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1

47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Equal modulated interaction of the iron regulatory proteins (IRP1 and IRP2) with canonical IREs controls iron-dependent translation of the ferritin subunits. +3 more findings

• Policy

Full summary, score breakdown and related studies → Original source

The role of microglia in amyloid clearance from the AD brain

49/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neural transmission (Vienna, Austria : 1996)

Key finding: It has been well accepted that AD pathogenesis arises from perturbation in the homeostasis of Abeta in the brain. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Regulation of amyloid precursor protein processing by the Beclin 1 complex

52/100 ✓ Peer-reviewed Risk genes beyond APOE PloS one

Key finding: Autophagy is initiated by the formation of a complex containing Beclin 1 (BECN1) and its binding partner Phosphoinositide-3-kinase, class 3 (PIK3C3). +3 more findings

Full summary, score breakdown and related studies → Original source

CSF amyloid-beta and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian ParkWest study

62/100 ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry

Key finding: CSF Aβ levels are altered in a subset of patients with early PD and relate to memory impairment. +3 more findings

• Biomarkers
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life

67/100 ✓ Peer-reviewed Prevention trials Annals of internal medicine

Key finding: An overall rating of the quality of evidence was assigned by using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) criteria. +2 more findings

• Prevention

Full summary, score breakdown and related studies → Original source

Replication of CLU, CR1, and PICALM associations with alzheimer disease

66/100 ✓ Peer-reviewed Risk genes beyond APOE Archives of neurology

Key finding: Follow-up case-control association study. +3 more findings

Full summary, score breakdown and related studies → Original source

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

40/100 ✓ Peer-reviewed Disease mechanisms Journal of Alzheimer s Disease

Key finding: Further investigation revealed expression of several neurospecific markers including synapse protein Sv2 and nuclear marker NeuN, as well as the presence of synapses and axonal vesicle transport. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Implication of the Immune System in Alzheimer's Disease: Evidence from Genome-Wide Pathway Analysis

40/100 ✓ Peer-reviewed Genetics Journal of Alzheimer s Disease

Key finding: The results of several genome-wide association studies (GWASs) in the field of Alzheimer's disease (AD) have recently been published. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

36/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: An immune-based therapy effective in reducing brain plaques, significantly reduced retinal Aβ plaque burden in immunized versus non-immunized AD mice (n=4 mice per group).

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source