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Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges
Leonardo Pantoni. The Lancet Neurology, 2010-06-17
Topic: Brain proteins, microglia and lab models
The text describes cerebral small vessel disease as a group of pathological processes affecting the brain's small vessels, with age-related and hypertension-related forms and cerebral amyloid angiopathy being most common. It explains that the consequences on the brain parenchyma mainly include subcortical lesions like lacunar infarcts, white matter lesions, large haemorrhages, and microbleeds. Furthermore, it notes that small vessel disease is a leading cause of cognitive decline and functional loss in the elderly, and should be a main target for prevention and treatment strategies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Pantoni, L. (2010). Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(10)70104-6
Vancouver
Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. The Lancet Neurology. 2010. doi:10.1016/s1474-4422(10)70104-6. PMID: 20610345.
BibTeX
@article{pantoni2010-20610345,
author = {Pantoni, Leonardo},
title = {{Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges}},
journal = {The Lancet Neurology},
year = {2010},
doi = {10.1016/s1474-4422(10)70104-6},
pmid = {20610345},
url = {https://doi.org/10.1016/s1474-4422(10)70104-6}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Age-related and hypertension-related small vessel diseases and cerebral amyloid angiopathy are the most common forms.
- The consequences of small vessel disease on the brain parenchyma are mainly lesions located in the subcortical structures such as lacunar infarcts, white matter lesions, large haemorrhages, and microbleeds.
- Small vessel disease has an important role in cerebrovascular disease and is a leading cause of cognitive decline and functional loss in the elderly.
Why it matters
Covers cerebral small vessel disease, from how it develops and its clinical characteristics to the challenges of treating it.
How this study scored 54/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 51 of the 95 points we could judge it on, which is 54 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 3,398 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 188.8 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 6 / 6 | Cited 44.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 730 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Leonardo Pantoni: h-index 87 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Florence: institution h-index 739 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20610345) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 51 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 51 of the 95 points we could judge it on is 54 out of 100. |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
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