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Regulation of amyloid precursor protein processing by the Beclin 1 complex
Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T.. PloS one, 2010-06-15
Topic: Brain proteins, microglia and lab models
Autophagy is an intracellular degradation pathway that functions in protein and organelle turnover in response to starvation and cellular stress. Autophagy is initiated by the formation of a complex containing Beclin 1 (BECN1) and its binding partner Phosphoinositide-3-kinase, class 3 (PIK3C3). Recently, BECN1 deficiency was shown to enhance the pathology of a mouse model of Alzheimer Disease (AD).
Key findings
- Autophagy is initiated by the formation of a complex containing Beclin 1 (BECN1) and its binding partner Phosphoinositide-3-kinase, class 3 (PIK3C3).
- Recently, BECN1 deficiency was shown to enhance the pathology of a mouse model of Alzheimer Disease (AD).
- However, the mechanism by which BECN1 or autophagy mediate these effects are unknown.
- Here, we report that the levels of Amyloid precursor protein (APP) and its metabolites can be reduced through autophagy activation, indicating that they are a substrate for autophagy.
Why it matters
In laboratory work, activating autophagy reduced levels of amyloid precursor protein and its breakdown products, suggesting a possible way to lower these proteins. This is early mechanistic research and does not show that boosting autophagy helps patients or changes the course of Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (PloS one) |
| Journal's citation record | 4 / 4 | PLoS ONE: journal h-index 594 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 200 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.1 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 4 / 6 | Cited 9.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 2 / 4 | Cited 20 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Tony Wyss‐Coray: h-index 106 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Stanford University: institution h-index 2,684 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20559548) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
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Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Jaeger, P. A., Pickford, F., Sun, C. H., Lucin, K. M., Masliah, E., & Wyss-Coray, T. (2010). Regulation of amyloid precursor protein processing by the Beclin 1 complex. PloS one. https://doi.org/10.1371/journal.pone.0011102
Vancouver
Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T. Regulation of amyloid precursor protein processing by the Beclin 1 complex. PloS one. 2010. doi:10.1371/journal.pone.0011102. PMID: 20559548.
BibTeX
@article{jaeger2010-20559548,
author = {Jaeger, P. A. and Pickford, F. and Sun, C. H. and Lucin, K. M. and Masliah, E. and Wyss-Coray, T.},
title = {{Regulation of amyloid precursor protein processing by the Beclin 1 complex}},
journal = {PloS one},
year = {2010},
doi = {10.1371/journal.pone.0011102},
pmid = {20559548},
url = {https://doi.org/10.1371/journal.pone.0011102}
}
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