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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 20,101–20,125 of 27,380 studies, newest first · page 805 of 1096.

May 2011 25

  1. 2011-05-31

    [Patients with mild cognitive impairment and a reduced CSF Aβ₁₋₄₂ protein progress rapidly to Alzheimer's disease]

    ✓ Peer-reviewed Tau biomarkers Neurologia (Barcelona, Spain)

    Key finding: Some studies have shown that CSF amyloid-beta 1-42 (Aβ₁₋₄₂), total tau (T-tau) and tau phosphorylated at threonine 181 (P-tau(181p)) proteins are useful diagnostic markers for distinguishing between clinically stable mild cognitive impairment (MCI) patients and those who will develop Alzheimeŕs disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2011-05-26

    Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of medicinal chemistry

    Key finding: Indeed leucettine L41 was demonstrated to modulate alternative pre-mRNA splicing, in a cell-based reporting system.

    Full summary, score breakdown and related studies → Original source

  3. 2011-05-26

    Associations between physical performance and executive function in older adults with mild cognitive impairment: gait speed and the timed "up & go" test

    ✓ Peer-reviewed Digital health tools Physical therapy

    Key finding: Physical performance speed was associated with executive function after adjusting for age, sex, and age-related factors in sedentary older adults with aMCI. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2011-05-26

    Measuring the quality of dying and quality of care when dying in long-term care settings: a qualitative content analysis of available instruments

    ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

    Key finding: Instruments that assess quality when dying differ in several ways and most do not measure a single construct, which is relevant to guiding and evaluating care. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2011-05-26

    Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) study, a randomized controlled trial

    ✓ Peer-reviewed Prevention trials BMC geriatrics

    Key finding: Good levels of participation, adherence, and retention appear to be achievable for participants through age 85 years. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2011-05-26

    Neuropathological background of phenotypical variability in frontotemporal dementia

    ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica

    Key finding: In addition, the clinical diagnosis of bvFTD does not have a strong relationship to any FTLD subtype or specific pathology and therefore remains a diagnostic challenge. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2011-05-24

    Self-efficacy for managing dementia may protect against burden and depression in Alzheimer's caregivers

    ✓ Peer-reviewed Cognitive tests and assessment Aging & mental health

    Key finding: Self-efficacy is the belief that one can perform a specific task or behaviour and is a modifiable attribute which has been shown to influence health behaviours. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2011-05-23

    Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

    Key finding: Oxidative DNA damage has been shown to be significantly elevated in Down syndrome patients, and this has been indicated as an early event promoting neurodegeneration and Alzheimer type dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2011-05-20

    Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases

    ✓ Peer-reviewed Treatments Cell death and differentiation

    Key finding: Emerging evidence has demonstrated that S-nitrosylation, representing covalent reaction of an NO group with a critical protein thiol, mediates the vast majority of NO signaling.

    Full summary, score breakdown and related studies → Original source

  10. 2011-05-20

    Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study

    ✓ Peer-reviewed How common it is BMC musculoskeletal disorders

    Key finding: During the study period, the risk of mortality in hip fracture patients was 3-fold higher than that in the general population and included every major cause of death. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2011-05-19

    The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

    ✓ Peer-reviewed End-of-life care Neuropharmacology

    Key finding: PF-04447943, (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one), a recently described PDE9 inhibitor, was found to have high affinity (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2011-05-19

    Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

    ✓ Peer-reviewed Risk factors The Journal of pathology

    Key finding: We found decreases in the levels and activities of several components of the insulin-PI3K-AKT signalling pathway in AD and T2DM cases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2011-05-18

    The natural history of treated Parkinson's disease in an incident, community based cohort

    ✓ Peer-reviewed Digital health tools Journal of neurology, neurosurgery, and psychiatry

    Key finding: Dementia risk is associated with increased age, impaired baseline semantic fluency and the MAPT H1/H1 genotype. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2011-05-18

    Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume

    ✓ Peer-reviewed Hippocampus size on brain scans The Journal of clinical psychiatry

    Key finding: Biological changes activated by stress represent a significant factor influencing brain structure and function in first-episode psychosis through an effect on BDNF. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2011-05-18

    Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: SVaD without abnormal amyloid imaging was more common than expected. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2011-05-17

    The use of the Digit Span Test in screening for cognitive impairment in acute medical inpatients

    ✓ Peer-reviewed Clinical safety International psychogeriatrics

    Key finding: Dementia and delirium were prevalent, yet under-recognized, in acute medical geriatric inpatients. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2011-05-15

    Change in comorbidity prevalence with advancing age among persons with heart failure

    ✓ Peer-reviewed Digital health tools Journal of general internal medicine

    Key finding: Among older Medicare beneficiaries with heart failure, there is a higher overall burden of comorbidity and greater prevalence of discordant comorbidity among the oldest old. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2011-05-15

    Clinical features and multidisciplinary approaches to dementia care

    ✓ Peer-reviewed Prevention and risk Journal of multidisciplinary healthcare

    Key finding: We provide a description of the risk factors, clinical presentation, and differential diagnosis of dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2011-05-13

    Association between environmental exposure to pesticides and neurodegenerative diseases

    ✓ Peer-reviewed Risk factors Toxicology and applied pharmacology

    Key finding: Prevalence rates and the risk of having Alzheimer's disease, Parkinson's disease, multiple sclerosis and suicide were significantly higher in districts with greater pesticide use as compared to those with lower pesticide use. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2011-05-12

    Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

    ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica

    Key finding: Accumulating experimental evidence in PD models suggests that astrogliosis and microgliosis act as important mediators of neurodegeneration playing a pivotal role in both disease initiation and progression. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2011-05-12

    A community-based exercise programme to improve functional ability in people with Alzheimer's disease: a randomized controlled trial

    ✓ Peer-reviewed Caregiving Scandinavian journal of caring sciences

    Key finding: Sixteen men and 24 women diagnosed with Alzheimer's disease participated in the study. +2 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2011-05-11

    Hippocampal dysfunction effects on context memory: possible etiology for posttraumatic stress disorder

    ✓ Peer-reviewed Hippocampus size on brain scans Neuropharmacology

    Key finding: Animal studies suggest that the hippocampus is required to form and recall associations between contextual stimuli and aversive events. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2011-05-10

    Caregiver burden, health utilities, and institutional service use in Alzheimer's disease

    ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry

    Key finding: Random effects results suggest that caregiver burden weakens the inverse relationship between health utilities and institutional service use, leading to greater likelihood of institutional use than would be expected at a given level of health. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2011-05-10

    Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial

    ✓ Peer-reviewed Treatments International journal of geriatric psychiatry

    Key finding: Naproxen may attenuate cognitive decline in slow decliners while accelerating decline in fast decliners. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2011-05-10

    APOE and Alzheimer disease: a major gene with semi-dominant inheritance

    ✓ Peer-reviewed Genetics Molecular psychiatry

    Key finding: Together, these results urge a reappraisal of the impact of APOE in Alzheimer disease.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →