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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 20,976–21,000 of 27,380 studies, newest first · page 840 of 1096.

February 2010 25

  1. 2010-02-04

    Acetylcholinesterase: from 3D structure to function

    ✓ Peer-reviewed Disease mechanisms Chemico-biological interactions

    Key finding: The crystal structure of recombinant human acetylcholinesterase in its apo-state is similar in its overall features to that of the Torpedo enzyme; however, the unique crystal packing reveals a novel peptide sequence which blocks access to the active-site gorge.

    Full summary, score breakdown and related studies → Original source

  2. 2010-02-04

    -1154G/A and -2578C/A polymorphisms of the vascular endothelial growth factor gene in Tunisian Alzheimer patients in relation to beta-amyloid (1-42) and total tau protein

    ✓ Peer-reviewed Tau biomarkers Neuroscience letters

    Key finding: To further investigate, we have analyzed association between promoter polymorphisms of the VEGF gene in 93 AD patients and age and sex matched 113 controls from Tunisian population. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2010-02-04

    Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment

    ✓ Peer-reviewed Getting a diagnosis Geriatrics & gerontology international

    Key finding: The Cronbach's alpha of MoCA-J as an index of internal consistency was 0.74.

    Full summary, score breakdown and related studies → Original source

  4. 2010-02-03

    TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

    ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Moreover, the role of wild-type (WT) TDP-43, associated with the majority of familial and sporadic ALS/FTLD patients, is also currently unknown. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2010-02 month only

    Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study

    ✓ Peer-reviewed Treatments CNS drugs

    Key finding: No statistically significant improvement in the primary outcome measures (MMSE and ADAS-Cog) was observed with drug therapy at 36 weeks, at which point all groups had lost, on average, 1 point on the MMSE and gained 2-3 points on the ADAS-Cog scale compared with baseline. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2010-02-01

    Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

    ✓ Peer-reviewed Inflammation and the immune system Neurobiology of aging

    Key finding: Here we describe specific and significant alterations in IGF-1R, IR, and their key substrate adaptor proteins IRS-1 and IRS-2 in Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2010-02-01

    Inflammation in neurodegenerative diseases

    ✓ Peer-reviewed Inflammation and the immune system Immunology

    Key finding: Apart from the pathogenic role of immune responses, emerging evidence indicates that immune responses are also critical for neuroregeneration.

    Full summary, score breakdown and related studies → Original source

  8. 2010-02-01

    Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

    ✓ Peer-reviewed Risk factors Neuron

    Key finding: Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2010-02-01

    Does lithium protect against dementia?

    ✓ Peer-reviewed Drug development Bipolar disorders

    Key finding: Continued treatment with lithium was associated with a reduced rate of dementia in patients with bipolar disorder in contrast to continued treatment with anticonvulsants, antidepressants, or antipsychotics. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2010-02-01

    White matter pathology isolates the hippocampal formation in Alzheimer's disease

    ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of aging

    Key finding: Prior work has demonstrated that the memory dysfunction of Alzheimer's disease (AD) is accompanied by marked cortical pathology in medial temporal lobe (MTL) gray matter. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2010-02-01

    Hippocampal plasticity in response to exercise in schizophrenia

    ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry

    Key finding: These results indicate that in both healthy subjects and patients with schizophrenia hippocampal volume is plastic in response to aerobic exercise. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2010-02-01

    Recommendations on end-of-life care for people with dementia

    ✓ Peer-reviewed End-of-life care The journal of nutrition, health & aging

    Key finding: In this article we aim to present these recommendations and to invite professionals to consider these important issues and to contribute towards a broader discussion.

    Full summary, score breakdown and related studies → Original source

  13. 2010-02-01

    Hospital characteristics associated with feeding tube placement in nursing home residents with advanced cognitive impairment

    ✓ Peer-reviewed End-of-life care JAMA

    Key finding: Among nursing home residents with advanced cognitive impairment admitted to acute care hospitals, for-profit ownership, larger hospital size, and greater ICU use was associated with increased rates of feeding tube insertion, even after adjusting for patient-level characteristics. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2010-02-01

    Extraskeletal effects of vitamin D in older adults: cardiovascular disease, mortality, mood, and cognition

    ✓ Peer-reviewed Clinical safety The American journal of geriatric pharmacotherapy

    Key finding: Forty-two case-control, cohort, and randomized trials were identified and included in the review. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2010-02-01

    Nutrition and the brain

    ✓ Peer-reviewed Prevention trials Clinics in geriatric medicine

    Key finding: Severe nutritional deficiencies, such as protein energy malnutrition and deficiency of nicotinamide, vitamin B(12), folate, and thiamine, have long been recognized to cause severe confusion. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2010-02-01

    Diet and neurocognition: review of evidence and methodological considerations

    ✓ Peer-reviewed Prevention trials Current aging science

    Key finding: The relationship between diet and cognitive function has been a topic of increasing interest, as numerous studies have shown that variations in dietary practices and nutrient intake may protect against age-related cognitive decline, as well as the development of dementia and Alzheimer's Disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2010-02-01

    Cognitive exercise and its role in cognitive function in older adults

    ✓ Peer-reviewed Prevention trials Current psychiatry reports

    Key finding: Converging lines of research indicate that complex mental activity is associated with reduced dementia risk. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2010-02-01

    What features improve the accuracy of the clinical diagnosis of progressive supranuclear palsy-parkinsonism (PSP-P)?

    ✓ Peer-reviewed Disease mechanisms Movement disorders : official journal of the Movement Disorder Society

    Key finding: Using a retrospective case notes review the clinical features were compared between the PSP-P group and Lewy body associated parkinsonism (PD, n = 444 and dementia with Lewy bodies (DLB), n = 46), MSA (n = 90), and VP (n = 19), using the chi(2)-test for proportions for a two-by-two contingency table. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2010-02-01

    Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Glia

    Key finding: Inflammatory and immune response pathways are chronically activated in AD patient brains at low levels, and likely play a role in disease progression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2010-02-01

    Systemic infection and delirium: when cytokines and acetylcholine collide

    ✓ Peer-reviewed Inflammation and the immune system Lancet (London, England)

    Key finding: Experimental findings and neuropathological observations suggest that activation of microglia is pivotal for mediation of the behavioural effects of systemic infections. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2010-02-01

    CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: However, the relationship between CSF biomarkers and brain morphometry is poorly understood. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2010-02-01

    The secretases: enzymes with therapeutic potential in Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Nature reviews. Neurology

    Key finding: Three proteases that are involved in the processing of amyloid precursor protein-alpha-secretase, beta-secretase and gamma-secretase-are of particular interest as they are central to the generation and modulation of amyloid-beta peptide and can be targeted by small compounds in vitro and in vivo. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2010-02-01

    Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Journal of neuroscience research

    Key finding: In the present study, compared to controls, we observed in hippocampus from subjects with MCI a significantly decreased level of PSD95, a key synaptic protein, and also decreased levels of two proteins associated with PSD95, the N-methyl-D-aspartate receptor, subunit 2A (NR2A) and the low-density lipoprotein receptor-1 (LRP1). +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2010-02-01

    Oxidative stress in the progression of Alzheimer disease in the frontal cortex

    ✓ Peer-reviewed Mild cognitive impairment Journal of neuropathology and experimental neurology

    Key finding: All 3 neuropil fractions (postmitochondrial supernatant, mitochondrial, and synaptosomal) demonstrated significant disease-dependent increases in oxidative markers. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2010-02-01

    Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery

    ✓ Peer-reviewed Lewy body dementia Journal of proteome research

    Key finding: TDP-43 interacting proteins largely cluster into two distinct interaction networks, a nuclear/splicing cluster and a cytoplasmic/translation cluster, strongly suggesting that TDP-43 has multiple roles in RNA metabolism and functions in both the nucleus and the cytoplasm. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →