Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 14,476–14,500 of 27,380 studies, newest first · page 580 of 1096.
December 2017 25
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2017-12-29
Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline
49/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy
Key finding: Cerebrovascular disease (CVD) and amyloid-β (Aβ) often coexist, but their influence on neurodegeneration and cognition in predementia stages remains unclear. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-28
Botanicals and phytochemicals active on cognitive decline: The clinical evidence
66/100 ✓ Peer-reviewed Prevention trials Pharmacological research
Key finding: Then, the aim of the present study was to review and comment the available evidence on botanicals and phytochemicals with a clinically demonstrable effect on cognitive decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-28
Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18
46/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: Test-retest analyses demonstrated low variability in flortaucipir F 18 SUVR. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-27
Underreporting of Gender and Race/Ethnicity Differences in NIH-Funded Dementia Caregiver Support Interventions
61/100 ✓ Peer-reviewed Caregiving American journal of Alzheimer's disease and other dementias
Key finding: The majority of studies included women and racial/ethnic minorities; however, 67% did not report results by gender or racial/ethnic group. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-12-27
Differential effects of childhood neglect and abuse during sensitive exposure periods on male and female hippocampus
38/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: Exposure at peak age had greater predictive importance than multiplicity, severity or duration. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-27
A Novel Screening Method to Identify Late-Stage Dementia Patients for Palliative Care Research and Practice
67/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: A novel method using an EHR phenotype plus brief medical record review is effective to identify hospitalized patients with late-stage dementia.
Full summary, score breakdown and related studies → Original source
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2017-12-27
Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia: a systematic review
76/100 ✓ Peer-reviewed Clinical safety Journal of physiotherapy
Key finding: Question Does physical exercise training improve physical function and quality of life in people with cognitive impairment and dementia? +3 more findings
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2017-12-27
Adherence to Mediterranean Diet and Frailty
62/100 ✓ Peer-reviewed Prevention trials Journal of the American Medical Directors Association
Key finding: According to study results, a higher adherence to the Mediterranean diet was associated with lower odds of frailty, irrespective of the definition used. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-27
The Efficacy of Cognitive Intervention in Mild Cognitive Impairment (MCI): a Meta-Analysis of Outcomes on Neuropsychological Measures
72/100 ✓ Peer-reviewed Prevention trials Neuropsychology review
Key finding: As such, this meta-analytic review was conducted to examine the efficacy of cognitive intervention in individuals diagnosed with mild cognitive impairment (MCI) versus MCI controls based on performance of neuropsychological outcome measures in randomized controlled trials (RCT). +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-27
Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample
53/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: [ 18 F]AV1451-PET and CSF p-tau had comparable value for differential diagnosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-27
Practice guideline update summary: Mild cognitive impairment [RETIRED]: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
74/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: MCI prevalence was 6.7% for ages 60-64, 8.4% for 65-69, 10.1% for 70-74, 14.8% for 75-79, and 25.2% for 80-84.
Full summary, score breakdown and related studies → Original source
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2017-12-27
CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP
63/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Both CSF p-tau and NfL correlate with disease severity and rate of disease progression in PSP. +3 more findings
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2017-12-26
The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases
38/100 ✓ Peer-reviewed Brain scans and imaging Movement disorders : official journal of the Movement Disorder Society
Key finding: High affinity of AV-1451 for monoamine oxidase proteins may limit its utility as a tau PET tracer in PSP and Alzheimer's disease because of high levels of monoamine oxidase expression in brain regions also affected by tau deposition, especially if monoamine oxidase levels change over time or with a treatment intervention. © 2017 International Parkinson and Movement Disorder Society. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-24
Efficacy of computer-based cognitive training in neuropsychological performance of patients with multiple sclerosis: A systematic review and meta-analysis
66/100 ✓ Peer-reviewed Prevention trials Multiple sclerosis and related disorders
Key finding: The present meta-analysis revealed a significant effect for computer-based cognitive training on the performance of the memory domain of patients with MS. This finding may have significant implications in the current treatment practice when cognitive decline is detected in MS patients. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-22
Neuroinflammatory responses in Alzheimer's disease
39/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neural transmission (Vienna, Austria : 1996)
Key finding: They involve various cellular and molecular players and associate interaction between the central nervous system (CNS) and the periphery. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-21
The role of microbial amyloid in neurodegeneration
52/100 ✓ Peer-reviewed Inflammation and the immune system PLoS pathogens
Key finding: Recent work has demonstrated that the microbiota also influences brain function in healthy and diseased individuals. +3 more findings
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2017-12-20
Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease
39/100 ✓ Peer-reviewed Drug development Chinese medical journal
Key finding: Amyloid plaques enriched with extracellular amyloid beta (Aβ) and intracellular neurofibrillary tangles comprised of hyperphosphorylated tau proteins are the two main pathological hallmarks of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-20
Analyzing the relationship between store attributes, satisfaction, patronage-intention and lifestyle in food and grocery store choice behavior
35/100 ✓ Peer-reviewed Risk factors International Journal of Retail & Distribution Management
Key finding: Practical implications With 100 percent foreign direct investment permitted in the F&G category in India, the research outcomes will be useful to all food retailers (prospective and current) interested in this retail market. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-20
Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages
42/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: In CN subjects, study-wide significant (P -9 ) loci were identified for total tau near SRRM4 and C14orf79 and for hippocampal volume near MTUS1. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-19
Exenatide exerts cognitive effects by modulating the BDNF-TrkB neurotrophic axis in adult mice
38/100 ✓ Peer-reviewed Drug development Neurobiology of aging
Key finding: Moreover, recent evidence indicates that GLP-1 modulates the activity of the brain-derived neurotrophic factor (BDNF). +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-12-19
Predictors of Smartphone Uses for Health Information Seeking in the Korean Elderly
38/100 ✓ Peer-reviewed Cognitive tests and assessment Social work in public health
Key finding: SHIS was significantly predicted by younger age, higher education levels, having a regular exercise, higher medical expenditures, and health literacy.
Full summary, score breakdown and related studies → Original source
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2017-12-19
Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies
38/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry
Key finding: Our findings revealed stark differences between FTDP-17 Tau variants in their ability to be seeded, with variants at Pro 301 and Ser 320 showing robust aggregation with seeding. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-19
Involvement of Astrocytes in Alzheimer's Disease from a Neuroinflammatory and Oxidative Stress Perspective
48/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in molecular neuroscience
Key finding: Although many explicative theories have been proposed, precise pathophysiological mechanisms are unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-19
The pathology and pathophysiology of vascular dementia
48/100 ✓ Peer-reviewed Brain tissue and pathology Neuropharmacology
Key finding: Consensus and accurate diagnosis of clinically suspected VaD relies on wide-ranging clinical, neuropsychological and neuroimaging measures in life but more importantly pathological confirmation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-12-19
Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
50/100 ✓ Peer-reviewed TREM2 and immune genetics Scientific reports
Key finding: Oxidative stress and inflammation are considered to play an important role in the development and progression of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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