Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,851–20,875 of 27,380 studies, newest first · page 835 of 1096.
April 2010 25
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2010-04-15
MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Aberrant expression and function of microRNAs has been observed in AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-15
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
56/100 ✓ Peer-reviewed Lewy body dementia Human molecular genetics
Key finding: Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative diseases with clinical and pathological overlap. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-15
Randomized, placebo-controlled, clinical trial of donepezil in vascular dementia: differential effects by hippocampal size
56/100 ✓ Peer-reviewed Treatments Stroke
Key finding: Donepezil was relatively well tolerated; adverse events were consistent with current labeling. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-04-14
Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines
36/100 ✓ Peer-reviewed Risk factors Pharmacological reviews
Key finding: Estrogen-based therapy therefore holds considerable promise for brain disorders that affect both men and women. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-14
Daily medication use in nursing home residents with advanced dementia
64/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Questionably beneficial medications are common in advanced dementia, even as death approaches. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-13
Current status on Alzheimer disease molecular genetics: from past, to present, to future
46/100 ✓ Peer-reviewed Genetics Human molecular genetics
Key finding: Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-12
EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity
36/100 ✓ Peer-reviewed Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America
Key finding: Recently, we demonstrated that the polyphenol (-)-epi-gallocatechine gallate (EGCG) inhibits alpha-synuclein and amyloid-beta fibrillogenesis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-12
Food combination and Alzheimer disease risk: a protective diet
58/100 ✓ Peer-reviewed Prevention and risk Archives of neurology
Key finding: Simultaneous consideration of previous knowledge regarding potentially AD-related nutrients and multiple food groups can aid in identifying food combinations that are associated with AD risk. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-12
Practice parameter update: evaluation and management of driving risk in dementia: report of the Quality Standards Subcommittee of the American Academy of Neurology
64/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: Systematic review of the literature using the American Academy of Neurology's evidence-based methods. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-04-11
Understanding amyloid aggregation by statistical analysis of atomic force microscopy images
36/100 ✓ Peer-reviewed Brain scans and imaging Nature nanotechnology
Key finding: Our results also indicate a possible general model for amyloid fibril assembly and illustrate the potential of this approach for investigating fibrillar systems.
Full summary, score breakdown and related studies → Original source
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2010-04-10
Vascular risk factor detection and control may prevent Alzheimer's disease
43/100 ✓ Peer-reviewed Prevention and risk Ageing research reviews
Key finding: Prevention-by-detection of VRF and target treatment, if found effective, could significantly promote healthier mental and physical aging and lessen the socio-economic calamity anticipated from the growing prevalence of dementia.
Full summary, score breakdown and related studies → Original source
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2010-04-09
Measurement of hippocampal atrophy using 4D graph-cut segmentation: application to ADNI
60/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage
Key finding: In this approach a 4D graph is used to represent the longitudinal data: edges are weighted based on spatial and intensity priors and connect spatially and temporally neighboring voxels represented by vertices in the graph. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-09
Machine-learning techniques for building a diagnostic model for very mild dementia
44/100 ✓ Peer-reviewed Digital health tools NeuroImage
Key finding: We found that there were significant performance differences across these seven diagnostic models.
Full summary, score breakdown and related studies → Original source
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2010-04-08
Underestimation of cognitive impairment by Mini-Mental State Examination versus the Montreal Cognitive Assessment in patients with transient ischemic attack and stroke: a population-based study
58/100 ✓ Peer-reviewed Getting a diagnosis Stroke
Key finding: The Mini-Mental State Examination (MMSE) is insensitive to mild cognitive impairment and executive function. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-04-07
MicroRNAs as biomarkers for CNS cancer and other disorders
42/100 ✓ Peer-reviewed Genetics Brain research
Key finding: The use of miRNAs as biomarkers has gained growing interest in the last few years. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-06
Korean version of mini mental status examination for dementia screening and its' short form
16/100 ⚠ Retracted — do not rely on it Cognitive tests and assessment Psychiatry investigation
Key finding: We developed a Korean version of Mini-Mental Status Examination (MMSE) optimized for screening dementia (MMSE-DS) and its' short form (SMMSE-DS). +3 more findings
Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2010-04-05
Relationships between age and late progression of Parkinson's disease: a clinico-pathological study
51/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology
Key finding: Cases were separated into five groups according to age at death, thus comparing patients who reached the advanced stage of the disease at different ages. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-05
Differential features of burden between spouse and adult-child caregivers of patients with Alzheimer's disease: an exploratory comparative design
52/100 ✓ Peer-reviewed Caregiving International journal of nursing studies
Key finding: Overall burden was greater among adult-child caregivers, especially those who lived with the patient and who had other family duties. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-03
Delirium in the emergency department: an independent predictor of death within 6 months
60/100 ✓ Peer-reviewed Caregiving Annals of emergency medicine
Key finding: As a result, we seek to determine whether delirium in the ED is independently associated with 6-month mortality in older patients and whether this relationship is modified by nursing home status. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-01
Drugs for Alzheimer's disease: are they effective?
40/100 ✓ Peer-reviewed End-of-life care PubMed Central
Key finding: Currently, five drugs have been approved by the FDA for use in AD, including four cholinesterase inhibitors and one N-methyl-d-aspartate (NMDA) receptor antagonist (see Drug Therapy). +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-01
Assessment and management of pressure ulcers in the elderly: current strategies
36/100 ✓ Peer-reviewed End-of-life care Drugs & aging
Key finding: If the ulcer has become chronic, the ultimate goal changes from healing the wound to controlling symptoms (such as foul odour, pain, discomfort and infection) and preventing complications, thereby contributing to the patient's overall well-being; providing support for the patient's family is also important.
Full summary, score breakdown and related studies → Original source
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2010-04-01
Trajectories of disability in the last year of life
67/100 ✓ Peer-reviewed End-of-life care The New England journal of medicine
Key finding: In most of the decedents, the course of disability in the last year of life did not follow a predictable pattern based on the condition leading to death.
Full summary, score breakdown and related studies → Original source
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2010-04-01
The relationship of 60 disease diagnoses and 15 conditions to preference-based health-related quality of life in Ontario hospital-based long-term care residents
40/100 ✓ Peer-reviewed Health systems and care delivery Medical care
Key finding: The findings suggest that diseases affect preference-based HRQoL differently in a hospital-based LTC population compared with previous studies in the general population. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-01
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
40/100 ✓ Peer-reviewed Disease mechanisms PloS one
Key finding: Our data suggest that inhibition of mTOR by rapamycin, an intervention that extends lifespan in mice, can slow or block AD progression in a transgenic mouse model of the disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-04-01
A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline
48/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology
Key finding: With the increased interest in the use of sequential magnetic resonance images as potential surrogate biomarkers of the disease process, it has also been shown that the rate of hippocampal atrophy is higher in persons with Alzheimer's disease compared to those with mild cognitive impairment and the healthy elderly. +4 more findings
Full summary, score breakdown and related studies → Original source
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