Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,701–20,725 of 27,380 studies, newest first · page 829 of 1096.
July 2010 25
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2010-07-01
Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification
36/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging
Key finding: MCI nonconverters (MCI-NC) had mixed baseline SPARE-AD and CSF values, suggesting that some MCI-NC subjects may later convert. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07-01
Elucidating the nature of deregulated semantic cognition in semantic aphasia: evidence for the roles of prefrontal and temporo-parietal cortices
36/100 ✓ Peer-reviewed Vascular contributions Journal of cognitive neuroscience
Key finding: Previous studies indicate that semantic dementia follows from a progressive yet specific degradation of conceptual knowledge. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Primary care and dementia: 2. Long-term care at home: psychosocial interventions, information provision, carer support and case management
64/100 ✓ Peer-reviewed End-of-life care International journal of geriatric psychiatry
Key finding: Caring for people with dementia in primary care demands the same systematic approach as the management of other long-term conditions.
Full summary, score breakdown and related studies → Original source
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2010-07-01
Documentation of advance care planning for community-dwelling elders
45/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Community-dwelling elders' preferences for end-of-life care are not consistent with documentation in their medical records.
Full summary, score breakdown and related studies → Original source
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2010-07-01
Cell-mediated neuroprotection in a mouse model of human tauopathy
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Together with evidence indicating that astrocyte transplantation may be neuroprotective, our findings suggest a beneficial role for glial cell-based repair in neurodegenerative diseases.
Full summary, score breakdown and related studies → Original source
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2010-07-01
Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection
40/100 ✓ Peer-reviewed Inflammation and the immune system Oxidative medicine and cellular longevity
Key finding: Increasing evidence suggests that α-synuclein aggregates can activate glial cells to induce neuroinflammation. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07-01
P3‐429: Response to cholinesterase inhibitor medication at first renewal in a Canadian provincial drug coverage initiative: the British Columbia Alzheimer's Drug Therapy Initiative (BC ADTI) experience
36/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia
Key finding: Assessment for renewal included SMMSE, GDS, and an Overall Patient Assessment Rating (OPAR): Very much improved (+4), Much improved (+2.5), Minimally improved (+1), grouped as positive response; No change (0) and Minimally worse (-1) grouped as indeterminate response; Much worse (-2.5) and Very much worse (-4) grouped as negative response. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07-01
Dietary antioxidants and long-term risk of dementia
64/100 ✓ Peer-reviewed Long-term cohort studies Archives of neurology
Key finding: The Rotterdam Study previously found that higher dietary intakes of vitamins E and C related to lower risk of dementia and Alzheimer disease (AD) over 6 years of follow-up. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Association between cognition and function in patients with Parkinson disease with and without dementia
47/100 ✓ Peer-reviewed Cognitive tests and assessment Movement disorders : official journal of the Movement Disorder Society
Key finding: Except in patients with dementia, the impact of cognitive symptoms on daily function is not well documented. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Could clinical profile influence CSF biomarkers in early-onset Alzheimer disease?
35/100 ✓ Peer-reviewed Tau biomarkers Alzheimer disease and associated disorders
Key finding: However, the disease, especially in its presenile forms, may also manifest itself through initial deficits that are predominantly of a nonmemory type. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease
42/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Pharmacological inhibition of calpain has been shown to improve memory and synaptic transmission in the mouse model of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
64/100 ✓ Peer-reviewed Mild cognitive impairment Archives of general psychiatry
Key finding: These results demonstrate an important role of clusterin in the pathogenesis of AD and suggest that alterations in amyloid chaperone proteins may be a biologically relevant peripheral signature of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update
51/100 ✓ Peer-reviewed Lewy body dementia Human mutation
Key finding: To date, molecular genetic analyses have identified over 500 distinct DNA variants in five disease genes associated with familial Parkinson disease; alpha-synuclein (SNCA), parkin (PARK2), PTEN-induced putative kinase 1 (PINK1), DJ-1 (PARK7), and Leucine-rich repeat kinase 2 (LRRK2).
Full summary, score breakdown and related studies → Original source
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2010-07-01
Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment
70/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: Our findings support the hypothesis that depression is a risk factor for dementia and suggest that recurrent depression is particularly pernicious. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis
82/100 ✓ Peer-reviewed How common it is JAMA
Key finding: Evidence suggests that delirium is associated with long-term poor outcome but delirium often occurs in individuals with more severe underlying disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Recruitment of a community-based cohort for research on diversity and risk of dementia
48/100 ✓ Peer-reviewed Disparities Alzheimer disease and associated disorders
Key finding: Implementation of these methods resulted in a dramatic increase in the number of ethnic minorities enrolled (and retained) in research protocols, including protocols that are complex and longitudinal. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Use of anticholinergics and the risk of cognitive impairment in an African American population
60/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: Limiting the clinical use of definite anticholinergics may reduce the incidence of cognitive impairment among African Americans. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07-01
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease
43/100 ✓ Peer-reviewed Brain scans and imaging Movement disorders : official journal of the Movement Disorder Society
Key finding: The CBS-AD subjects were younger at the time of scan when compared with CBS-CBD subjects (median: 60 years vs. 69; P = 0.04). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Vascular and degenerative processes differentially affect regional interhemispheric connections in normal aging, mild cognitive impairment, and Alzheimer disease
42/100 ✓ Peer-reviewed Brain scans and imaging Stroke
Key finding: We found differential region-specific associations between degenerative and vascular processes and the structural integrity of the CC across the spectrum of cognitive ability. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
White matter changes and diabetes predict cognitive decline in the elderly: the LADIS study
53/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: WMC severity and diabetes are independent predictors of cognitive decline in an initially nondisabled elderly population.
Full summary, score breakdown and related studies → Original source
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2010-07-01
Alzheimer's disease: clinical trials and drug development
60/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: Research into Alzheimer's disease therapy has been at least partly successful in terms of developing symptomatic treatments, but has also had several failures in terms of developing disease-modifying therapies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Vitamin D and risk of cognitive decline in elderly persons
66/100 ✓ Peer-reviewed Prevention and risk Archives of internal medicine
Key finding: Low levels of vitamin D were associated with substantial cognitive decline in the elderly population studied over a 6-year period, which raises important new possibilities for treatment and prevention. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Pilot study to show the feasibility of a multicenter trial of home-based assessment of people over 75 years old
41/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: In this sample of older individuals, a higher dropout rate occurred in those assigned to the high-technology assessment techniques; however, once participants had completed baseline in all 3 arms, they continued participation through 1 month. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-07-01
Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease
54/100 ✓ Peer-reviewed Genetics Neurology
Key finding: This study suggests that larger head circumference is associated with less cognitive impairment in the face of cerebral atrophy. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-07-01
Serial MRI and CSF biomarkers in normal aging, MCI, and AD
55/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Unlike the CSF biomarkers evaluated, changes in serial structural MRI are correlated with concurrent change on general cognitive and functional indices in impaired subjects, track with clinical disease stage, and are influenced by APOE genotype. +2 more findings
Full summary, score breakdown and related studies → Original source
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