alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 19,476–19,500 of 27,380 studies, newest first · page 780 of 1096.

May 2012 25

  1. 2012-05-10

    Wavelet coherence model for diagnosis of Alzheimer disease

    ✓ Peer-reviewed Brain scans and imaging Clinical EEG and neuroscience

    Key finding: A one-way analysis of variance test shows a set of statistically significant differences in wavelet coherence between AD and controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2012-05-09

    Heterogeneity of cholinergic denervation in Parkinson's disease without dementia

    ✓ Peer-reviewed Clinical safety Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: The low neocortical acetylcholinesterase activity subgroup had significantly lower global cognitive performance compared with the normal range subgroup (F=7.64, P=0.0069) with an independent effect for nigrostriatal denervation (F=7.60, P=0.0074). +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2012-05-08

    Is dementia incidence declining? Trends in dementia incidence since 1990 in the Rotterdam Study

    ✓ Peer-reviewed How common it is Neurology

    Key finding: Incidence rate ratio for dementia was 0.75 (95% CI 0.56-1.02) comparing the 2000 vs 1990 subcohort +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2012-05-07

    Behavioral and psychological symptoms of dementia

    ✓ Peer-reviewed Risk factors Frontiers in neurology

    Key finding: It is estimated that BPSD affect up to 90% of all dementia subjects over the course of their illness, and is independently associated with poor outcomes, including distress among patients and caregivers, long-term hospitalization, misuse of medication, and increased health care costs. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2012-05-04

    The role of neuronal calcium sensors in balancing synaptic plasticity and synaptic dysfunction

    ✓ Peer-reviewed Disease mechanisms Frontiers in molecular neuroscience

    Key finding: These interactions lead to dynamic alterations in protein trafficking that significantly impact upon synaptic function. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2012-05-04

    Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: Thus, interventions targeting HFD-induced metabolic dysfunctions may be effective in preventing the development of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2012-05-04

    How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder

    ✓ Peer-reviewed Risk factors Brain : a journal of neurology

    Key finding: Their results on motor testing from the preceding years were plotted, and then assessed with regression analysis, to determine when markers first deviated from normal values. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2012-05-03

    Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease

    ✓ Peer-reviewed Brain scans and imaging Progress in retinal and eye research

    Key finding: We review the cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2012-05-03

    Chronic kidney disease and cognitive impairment: a systematic review and meta-analysis

    ✓ Peer-reviewed Risk factors American journal of nephrology

    Key finding: Most cross-sectional and longitudinal studies suggest an association between cognitive impairment and CKD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2012-05-02

    Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study

    ✓ Peer-reviewed How common it is Neurology

    Key finding: In the 1990 subcohort (25,696 person-years), 286 persons developed dementia, and in the 2000 subcohort (8,384 person-years), 49 persons. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2012-05-02

    Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Of the 296 initially normal subjects, 31 (10%) progressed to a diagnosis of mild cognitive impairment (MCI) or dementia (27 amnestic MCI, 2 nonamnestic MCI, and 2 non-AD dementias) within 1 year.

    Full summary, score breakdown and related studies → Original source

  12. 2012-05-01

    The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment

    ✓ Peer-reviewed Getting a diagnosis Cold Spring Harbor perspectives in medicine

    Key finding: Clinicopathological studies support the presence of a long preclinical phase of the disease, with the initial deposition of AD pathology estimated to begin approximately 10-15 years prior to the onset of clinical symptoms. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2012-05-01

    Transitions in care for older adults with and without dementia

    ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

    Key finding: Individuals with dementia live and frequently die in community settings.

    Full summary, score breakdown and related studies → Original source

  14. 2012-05-01

    Patient-related risk factors for periprosthetic joint infection and postoperative mortality following total hip arthroplasty in Medicare patients

    ✓ Peer-reviewed Costs and economics The Journal of bone and joint surgery. American volume

    Key finding: The purpose of this study was to identify the specific patient comorbidities that are associated with an increased risk of periprosthetic joint infection and of ninety-day postoperative mortality in U.S. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2012-05-01

    Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

    ✓ Peer-reviewed Drug development Current Alzheimer research

    Key finding: Recent data indicate that Tau immunotherapy may be relevant for interfering with neurofibrillary degeneration in Alzheimer disease and related disorders referred to as Tauopathies. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2012-05-01

    Association of lifetime cognitive engagement and low β-amyloid deposition

    ✓ Peer-reviewed Brain scans and imaging Archives of neurology

    Key finding: Individuals with greater early- and middle-life cognitive activity had lower [(11)C]PiB uptake. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2012-05-01

    Hypertension in the elderly

    ✓ Peer-reviewed Vascular contributions World journal of cardiology

    Key finding: Data collected over a 30-year period have demonstrated the increasing prevalence of hypertension with age.

    Full summary, score breakdown and related studies → Original source

  18. 2012-05-01

    Childhood socioeconomic status and adult brain size: childhood socioeconomic status influences adult hippocampal size

    ✓ Peer-reviewed Hippocampus size on brain scans Annals of neurology

    Key finding: A significant association between childhood SES and hippocampal volumes in late life is consistent with the established neurodevelopmental findings that early life conditions have an effect on structural brain development. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2012-05-01

    Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium

    ✓ Peer-reviewed Clinical safety The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Intracerebroventricular injection of mu-p75-sap produced depletion of cholinergic neurons in the basal forebrain and decreased innervation of the hippocampus, but left performance on hippocampal-dependent reference and working memory tasks relatively intact. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2012-05-01

    Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

    ✓ Peer-reviewed Inflammation and the immune system Neuron

    Key finding: Microglia engulf presynaptic inputs during peak retinogeniculate pruning +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2012-05-01

    Contributions of the Framingham Heart Study to stroke and dementia epidemiologic research at 60 years

    ✓ Peer-reviewed Long-term cohort studies Archives of neurology

    Key finding: During the ensuing decades, the study of other diseases, notably stroke and dementia, was added. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2012-05-01

    Trafficking and proteolytic processing of APP

    ✓ Peer-reviewed Risk genes beyond APOE Cold Spring Harbor perspectives in medicine

    Key finding: Amyloid β-peptide is derived by sequential proteolytic processing from a large type I trans-membrane protein, the β-amyloid precursor protein. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2012-05-01

    Does lithium prevent Alzheimer's disease?

    ✓ Peer-reviewed Mild cognitive impairment Drugs & aging

    Key finding: In humans, lithium treatment has been associated with humoral and structural evidence of neuroprotection, such as increased expression of anti-apoptotic genes, inhibition of cellular oxidative stress, synthesis of brain-derived neurotrophic factor (BDNF), cortical thickening, increased grey matter density, and hippocampal enlargement. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2012-05-01

    Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: This study provides initial data that demonstrate elevated antibodies to periodontal disease bacteria in subjects years before cognitive impairment and suggests that periodontal disease could potentially contribute to the risk of AD onset/progression. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2012-05-01

    Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies

    ✓ Peer-reviewed Risk factors Internal medicine journal

    Key finding: The quantitative meta-analysis showed that subjects with diabetes had higher risk for AD (relative risk (RR):1.46, 95% confidence interval (CI): 1.20-1.77), VD (RR: 2.48, 95% CI: 2.08-2.96), any dementia (RR: 1.51, 95% CI: 1.31-1.74) and MCI (RR: 1.21, 95% CI: 1.02-1.45) than those without. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →