Implication of the Immune System in Alzheimer's Disease: Evidence from Genome-Wide Pathway Analysis
Jean‐Charles Lambert, Benjamin Grenier‐Boley, Vincent Antoine Chouraki, Simon Charles Heath, Diana Zélénika, Nathalie Fiévet, Didier Hannequin, Florence Pasquier et al.. Journal of Alzheimer s Disease, 2010-06-13
Topic: Genetics and APOE
The results of several genome-wide association studies (GWASs) in the field of Alzheimer's disease (AD) have recently been published. Although these studies reported in detail on single-nucleotide polymorphisms (SNPs) and the neighboring genes with the strongest evidence of association with AD, little attention was paid to the rest of the genome. However, complementary statistical and bio-informatics approaches now enable the extraction of pertinent information from other SNPs and/or genes which are only nominally associated with the disease risk. Two different tools (the ALIGATOR and GenGen/KEGG software packages) were used to analyze a large GWAS dataset containing 2,032 AD cases and 5,328 controls. Convergent outputs from the two gene set enrichment approaches suggested an immune system dysfunction in AD. Furthermore, although these statistical approaches did not adopt a priori hypotheses concerning a biological function's putative role in the disease process, genes associated with AD risk were overrepresented in the "Alzheimer's disease" KEGG pathway. In conclusion, a systematic search for biological pathways using GWAS data set seems to comfort the primary causes already suspected but may specifically highlight the importance of the immune system in AD.
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APA 7th
Lambert, J., Grenier‐Boley, B., Chouraki, V. A., Heath, S. C., Zélénika, D., Fiévet, N., et al. (2010). Implication of the Immune System in Alzheimer's Disease: Evidence from Genome-Wide Pathway Analysis. Journal of Alzheimer s Disease. https://doi.org/10.3233/jad-2010-100018
Vancouver
Lambert J, Grenier‐Boley B, Chouraki VA, Heath SC, Zélénika D, Fiévet N, et al. Implication of the Immune System in Alzheimer's Disease: Evidence from Genome-Wide Pathway Analysis. Journal of Alzheimer s Disease. 2010. doi:10.3233/jad-2010-100018. PMID: 20413860.
BibTeX
@article{lambert2010-20413860,
author = {Lambert, Jean‐Charles and Grenier‐Boley, Benjamin and Chouraki, Vincent Antoine and Heath, Simon Charles and Zélénika, Diana and Fiévet, Nathalie and Hannequin, Didier and Pasquier, Florence and others},
title = {{Implication of the Immune System in Alzheimer's Disease: Evidence from Genome-Wide Pathway Analysis}},
journal = {Journal of Alzheimer s Disease},
year = {2010},
doi = {10.3233/jad-2010-100018},
pmid = {20413860},
url = {https://doi.org/10.3233/jad-2010-100018}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- The results of several genome-wide association studies (GWASs) in the field of Alzheimer's disease (AD) have recently been published.
- However, complementary statistical and bio-informatics approaches now enable the extraction of pertinent information from other SNPs and/or genes which are only nominally associated with the disease risk.
- Furthermore, although these statistical approaches did not adopt a priori hypotheses concerning a biological function's putative role in the disease process, genes associated with AD risk were overrepresented in the "Alzheimer's disease" KEGG pathway.
- In conclusion, a systematic search for biological pathways using GWAS data set seems to comfort the primary causes already suspected but may specifically highlight the importance of the immune system in AD.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 23 of the 58 points we could judge it on, which is 40 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20413860) |
| Free to read | 2 / 2 | Free to read |
| Points | 23 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 23 of the 58 points we could judge it on is 40 out of 100. |
| Total | 40 / 100 | — |
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