Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,601–20,625 of 27,380 studies, newest first · page 825 of 1096.
September 2010 12
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2010-09-01
The word processing deficit in semantic dementia: all categories are equal, but some categories are more equal than others
43/100 ✓ Peer-reviewed Digital health tools Journal of cognitive neuroscience
Key finding: Furthermore, this specific pattern of deficits cannot be captured by classic category distinctions such as nouns versus verbs or living versus nonliving things. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-09-01
Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants
52/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology
Key finding: Prospective studies have shown that although the beneficial effects of this procedure are maintained at 5 years, axial motor features and cognitive decline may occur in the long term after the implants. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-01
Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the U.K
63/100 ✓ Peer-reviewed How common it is The British journal of dermatology
Key finding: Severe psoriasis is associated with an increased risk of death from a variety of causes, with cardiovascular death being the most common aetiology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-01
Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis
65/100 ✓ Peer-reviewed How common it is Neurology
Key finding: MCI is common in patients with PD without dementia, affecting a range of cognitive domains, including memory, visual-spatial, and attention/executive abilities. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-09-01
A biobehavioral home-based intervention and the well-being of patients with dementia and their caregivers: the COPE randomized trial
72/100 ✓ Peer-reviewed Caregiving JAMA
Key finding: Among community-living dyads, a nonpharmacologic biobehavioral environmental intervention compared with control resulted in better outcomes for COPE dyads at 4 months. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-01
Distinct cerebral perfusion patterns in FTLD and AD
54/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Doubly dissociated areas of hypoperfusion in FTLD and AD are consistent with areas of significant histopathologic burden in these groups. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-01
18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial
71/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology
Key finding: (18)F-Flutemetamol performs similarly to the (11)C-PIB parent molecule within the same subjects and provides high test-retest replicability and potentially much wider accessibility for clinical and research use. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-01
Older patients in the emergency department: a review
45/100 ✓ Peer-reviewed Getting a diagnosis Annals of emergency medicine
Key finding: Increased frailty, delayed diagnosis, and greater illness severity contribute to a higher risk of adverse outcomes.
Full summary, score breakdown and related studies → Original source
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2010-09-01
Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging
63/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Among 1,969 subjects without dementia, 329 subjects had MCI, with a prevalence of 16.0% (95% confidence interval [CI] 14.4-17.5) for any MCI, 11.1% (95% CI 9.8-12.3) for amnestic MCI, and 4.9% (95% CI 4.0-5.8) for nonamnestic MCI. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-01
Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke
48/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology
Key finding: Cognitive dysfunction ranges from focal deficits, resulting directly from an area of infarction or from hypoperfusion in adjacent tissue, to more global cognitive dysfunction. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-01
A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2
51/100 ✓ Peer-reviewed Genetics Neurology
Key finding: This comprehensive population genetic study in control subjects fills the void for a PARK2 reference dataset. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-09-01
A serum protein-based algorithm for the detection of Alzheimer disease
59/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: These initial data suggest that serum protein-based biomarkers can be combined with clinical information to accurately classify AD. +2 more findings
Full summary, score breakdown and related studies → Original source
August 2010 13
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2010-08-27
Encephalopathies: the emerging diabetic complications
40/100 ✓ Peer-reviewed Brain scans and imaging Acta diabetologica
Key finding: The increased incidence of Alzheimer's disease in type 2 diabetes is associated with insulin resistance, hyperinsulinemia and hyperglycemia, and commonly accompanying attributes such as hypercholesterolemia, hypertension and obesity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-08-25
Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice
42/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Previously, we showed that human apolipoprotein A-I (apoA-I) decreases Aβ(40) aggregation and toxicity. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-08-25
Cognitive impairment and 7-year mortality in dialysis patients
57/100 ✓ Peer-reviewed Prevention and risk American journal of kidney diseases : the official journal of the National Kidney Foundation
Key finding: Cognitive impairment is an independent predictor of mortality in dialysis patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-08-25
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice
46/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: ABCA1 was required to observe significantly elevated apoE levels in brain tissue and cerebrospinal fluid upon therapeutic (33 mg/kg/day) GW3965 treatment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-08-25
Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study
50/100 ✓ Peer-reviewed Genetics Neurology
Key finding: The results of this study suggest that hyperinsulinemia and hyperglycemia caused by insulin resistance accelerate NP formation in combination with the effects of APOE epsilon4. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-08-25
Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study
58/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Elderly patients with diabetes develop more extensive vascular pathology, which alone or together with AD-type pathology (particularly in APOE ε4 carriers) results in increased dementia risk. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-08-23
The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model
31/100 ✓ Peer-reviewed Biomarkers Phytomedicine : international journal of phytotherapy and phytopharmacology
Key finding: This study offers evidence of functional and neuroprotective effects of two weeks treatment with a Ptychopetalum olacoides extract against Aβ peptide-induced neurotoxicity in mice.
Full summary, score breakdown and related studies → Original source
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2010-08-22
Metals, oxidative stress and neurodegenerative disorders
36/100 ✓ Peer-reviewed Inflammation and the immune system Molecular and cellular biochemistry
Key finding: Biochemical analysis of amyloid plaques revealed that the main constituent is fibrillar aggregates of a 39-42 residue peptide referred to as the amyloid-β protein (Aβ). +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-08-22
A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain research
Key finding: Animal research has indicated that aerobic exercise is related to increased cell proliferation and survival in the hippocampus as well as enhanced hippocampal-dependent learning and memory. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-08-21
Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study
74/100 ✓ Peer-reviewed Treatments Dementia and geriatric cognitive disorders
Key finding: No evidence of efficacy of 2 mg or 8 mg RSG XR monotherapy in cognition or global function was detected in the APOE-ε4-negative or other analysis populations. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-08-20
Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial
71/100 ✓ Peer-reviewed Treatments The Lancet. Neurology
Key finding: No significant differences were noted between the two treatments in patients with PDD (3·6 with memantine vs 3·8 with placebo, -0·1 [-0·6 to 0·3]; p=0·576) or in the total population (3·5 with memantine vs 3·8 with placebo, -0·3 [-0·7 to 0·1]; p=0·120). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-08-19
Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats
36/100 ✓ Peer-reviewed Drug development Neuroscience
Key finding: The results showed that (1) Aβ1-40 (5 nmol) injection did not affect the baseline field excitatory postsynaptic potentials (fEPSPs), but significantly suppressed multiple high frequency stimulation (HFS)-induced L-LTP in hippocampal CA1 region; (2) Val(8)-GLP-1(7-36) (0.05 pmol) administration alone did not affect the baseline synaptic transmission and the maintenance of L-LTP; (3) pretreatment with Val(8)-GLP-1(7-36) (0.05 pmol) effectively prevented Aβ1-40-induced deficit of L-LTP; (4) i.c.v. injection of 5 nmol Aβ1-40 resulted in a significant decline learning a spatial Morris water maze (MWM) test; (5) Val(8)-GLP-1(7-36) (0.05 pmol) administration alone did not affect spatial learning in this task, while pretreatment with Val(8)-GLP-1(7-36) effectively reversed the impairment of spatial learning and memory induced by Aβ1-40. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-08-18
A systematic review of the prevalence, associations and outcomes of dementia in older general hospital inpatients
60/100 ✓ Peer-reviewed Clinical safety International psychogeriatrics
Key finding: When planning liaison services, the setting and demographic features of the population need to be taken into account. +4 more findings
Full summary, score breakdown and related studies → Original source
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