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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 20,751–20,775 of 27,380 studies, newest first · page 831 of 1096.

June 2010 25

  1. 2010-06-11

    Boosting power for clinical trials using classifiers based on multiple biomarkers

    ✓ Peer-reviewed Digital health tools Neurobiology of aging

    Key finding: We created a Support Vector Machine algorithm that combines brain imaging and other biomarkers to classify 737 Alzheimer's disease Neuroimaging initiative (ADNI) subjects as having Alzheimer's disease (AD), mild cognitive impairment (MCI), or normal controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2010-06-11

    Automatic classification of patients with Alzheimer's disease from structural MRI: a comparison of ten methods using the ADNI database

    ✓ Peer-reviewed Brain scans and imaging NeuroImage

    Key finding: For the prediction of conversion, no classifier obtained significantly better results than chance. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2010-06-11

    3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

    ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of aging

    Key finding: All CSF measures showed significant associations with hippocampal volume and radial distance in the pooled sample.

    Full summary, score breakdown and related studies → Original source

  4. 2010-06-11

    The role of inflammation in the pathogenesis of delirium and dementia in older adults: a review

    ✓ Peer-reviewed Clinical safety CNS neuroscience & therapeutics

    Key finding: Delirium and dementia share similarities in clinical and pathogenic features, leading to the speculation that instead of being distinct clinical entities, the two age-related conditions may be linked by a common pathogenic mechanism. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2010-06-11

    Enrichment through biomarkers in clinical trials of Alzheimer's drugs in patients with mild cognitive impairment

    ✓ Peer-reviewed Long-term cohort studies Neurobiology of aging

    Key finding: Four hundred five MCI patients (143 converters and 262 nonconverters to AD within 2 years) of the Alzheimer's disease Neuroimaging Initiative (ADNI) were used. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2010-06-11

    3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects

    ✓ Peer-reviewed Cognitive tests and assessment Neurobiology of aging

    Key finding: Here we mapped the 3D profile of caudate atrophy using a surface mapping approach in subjects with AD and mild cognitive impairment (MCI) to identify potential clinical and pathological correlates. 3D surface models of the caudate were automatically extracted from 400 baseline MRI scans (100 AD, 200 MCI, 100 healthy elderly). +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2010-06-11

    The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort

    ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging

    Key finding: For most biomarkers the sigmoid model fitted data significantly better than the linear model. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2010-06-11

    Prevalence and pattern of cognitive impairment in rural and urban populations from Northern Portugal

    ✓ Peer-reviewed Disparities BMC neurology

    Key finding: The prevalence of cognitive impairment is higher in rural compared with urban populations. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2010-06-10

    Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

    ✓ Peer-reviewed Risk genes beyond APOE Cell

    Key finding: In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autophagosome clearance during macroautophagy are prevented as a result of a selective impairment of autolysosome acidification and cathepsin activation.

    Full summary, score breakdown and related studies → Original source

  10. 2010-06-09

    Hospitalization in community-dwelling persons with Alzheimer's disease: frequency and causes

    ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

    Key finding: In a community-dwelling population with generally mild AD, hospitalization is frequent, occurring in two-thirds of participants over a median follow-up time of 3 years. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2010-06-09

    Subtypes based on cerebrospinal fluid and magnetic resonance imaging markers in normal elderly predict cognitive decline

    ✓ Peer-reviewed Long-term cohort studies Neurobiology of aging

    Key finding: The Alzheimer's Disease Neuroimaging Initiative (ADNI) studied normal controls (NC), subjects with mild cognitive impairment (MCI), and subjects with AD to identify patterns of biomarkers to aid in early diagnosis and effective treatment of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2010-06-08

    Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: evidence in optical coherence tomography

    ✓ Peer-reviewed Brain scans and imaging Neuroscience letters

    Key finding: Compared with healthy age-matched controls, the RNFL thickness of AD patients were much thinner (p<0.05), especially in supra-retina and infra-retina, while no difference was found in the other retinal area. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2010-06-08

    Neurotoxic effects of TDP-43 overexpression in C. elegans

    ✓ Peer-reviewed Brain tissue and pathology Human molecular genetics

    Key finding: We have engineered pan-neuronal expression of human TDP-43 protein in Caenorhabditis elegans, with the goal of generating a convenient in vivo model of TDP-43 function and neurotoxicity. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2010-06-08

    Obesity is linked with lower brain volume in 700 AD and MCI patients

    ✓ Peer-reviewed Long-term cohort studies Neurobiology of aging

    Key finding: To determine if higher body mass index (BMI) is associated with brain volume deficits in cognitively impaired elderly subjects, we analyzed brain magnetic resonance imaging (MRI) scans of 700 MCI or AD patients from 2 different cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Cardiovascular Health Study-Cognition Study (CHS-CS). +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2010-06-04

    Prevalence of psychiatric disorders among older adults in long-term care homes: a systematic review

    ✓ Peer-reviewed How common it is International psychogeriatrics

    Key finding: Dementia, depression and anxiety disorders are the most common psychiatric disorders among older adults in LTC. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2010-06-03

    Utilization patterns of ambulatory medical care before and after the diagnosis of dementia in Germany--results of a case-control study

    ✓ Peer-reviewed Digital health tools Dementia and geriatric cognitive disorders

    Key finding: Service utilization by demented patients increases already within the year before the first diagnosis and stays on a relatively high level within the year after.

    Full summary, score breakdown and related studies → Original source

  17. 2010-06-03

    Niemann-Pick disease type C

    ✓ Peer-reviewed Getting a diagnosis Orphanet journal of rare diseases

    Key finding: Genotyping of patients is useful to confirm the diagnosis in the latter patients and essential for future prenatal diagnosis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2010-06-02

    Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment

    ✓ Peer-reviewed Disease mechanisms Journal of Neuroscience

    Key finding: In contrast to Alzheimer's disease (AD), in which circuit disruption occurs through neuron death, AAMI is due to circuit and synapse disruption in the absence of significant neuron loss and thus may be more amenable to prevention or treatment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2010-06-01

    Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Behavioral neuroscience

    Key finding: Specifically, the adult offspring of choline-supplemented Ts65Dn dams performed significantly better than unsupplemented Ts65Dn mice on a series of 5 visual attention tasks, and in fact, on some tasks did not differ from the normosomic (2N) controls. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2010-06-01

    Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease

    ✓ Peer-reviewed Drug development Recent patents on CNS drug discovery

    Key finding: The receptors for GIP and GLP-1 are expressed in neurons, and both GIP and GLP-1 are expressed and released as transmitters by neurons. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2010-06-01

    Amygdala and hippocampus enlargement during adolescence in autism

    ✓ Peer-reviewed Hippocampus size on brain scans Journal of the American Academy of Child and Adolescent Psychiatry

    Key finding: The abnormal enlargement of the amygdala and hippocampus in adolescents with autism adds to previous findings of enlargement of these structures in children with autism. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2010-06-01

    Withholding, discontinuing and withdrawing medications in dementia patients at the end of life: a neglected problem in the disadvantaged dying?

    ✓ Peer-reviewed End-of-life care Drugs & aging

    Key finding: Significant research must be undertaken in the area of medication discontinuation in patients with advanced dementia nearing the end of life to determine how physicians currently decide whether medications should be discontinued, and also to develop the evidence base and provide guidance on systematic medication discontinuation.

    Full summary, score breakdown and related studies → Original source

  23. 2010-06-01

    A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration

    ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Indeed, several endogenous presynaptic proteins involved in exocytosis and endocytosis were undetectable in a subset of transgenic boutons ("vacant synapses") with diminished levels in the remainder, suggesting that such diminutions were triggering the overall synaptic pathology.

    Full summary, score breakdown and related studies → Original source

  24. 2010-06-01

    TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97

    ✓ Peer-reviewed Brain tissue and pathology The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: VCP (p97 in mouse, TER94 in Drosophila melanogaster, and CDC48 in Saccharomyces cerevisiae) is a highly conserved AAA(+) (ATPases associated with multiple cellular activities) ATPase that regulates a wide array of cellular processes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2010-06-01

    In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)

    ✓ Peer-reviewed Brain tissue and pathology Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: An (18)F-labeled PET amyloid-beta (Abeta) imaging agent could facilitate the clinical evaluation of late-life cognitive impairment by providing an objective measure for Alzheimer disease (AD) pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →