Newest studies

The measurement of everyday cognition (ECog): scale development and psychometric properties

36/100 ✓ Peer-reviewed Risk factors Neuropsychology

Key finding: External validity was evaluated by comparing ECog results across different clinical groups [cognitively normal, mild cognitive impairment (MCI), dementia]. +1 more finding

• Early Stage

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Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

70/100 ✓ Peer-reviewed Clinical trials Lancet (London, England)

Key finding: 155 (85%) patients completed the trial (78 [88%] in dimebon group, 77 [82%] in placebo group). +4 more findings

• Clinical Trials

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Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons

36/100 ✓ Peer-reviewed Treatments Journal of neurochemistry

Key finding: In this study, we showed that NMDA and oligomeric Abeta(1-42) could induce reactive oxygen species (ROS) production from cortical neurons through activation of NADPH oxidase. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Tau-based treatment strategies in neurodegenerative diseases

36/100 ✓ Peer-reviewed Drug development Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Key finding: The present review, therefore, focuses on therapeutic approaches that aim to inhibit tau phosphorylation and aggregation or to dissolve preexisting tau aggregates. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Modulation of temporally coherent brain networks estimated using ICA at rest and during cognitive tasks

36/100 ✓ Peer-reviewed Brain scans and imaging Human brain mapping

Key finding: Recent studies have examined ways TCNs can be used to identify patterns associated with various brain disorders (e.g. schizophrenia, autism or Alzheimer's disease). +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Thyroid function and the risk of Alzheimer disease: the Framingham Study

48/100 ✓ Peer-reviewed Vascular contributions Archives of internal medicine

Key finding: Low and high thyrotropin levels were associated with an increased risk of incident AD in women but not in men. +4 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study

71/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: Statin users were less likely to have incident dementia/cognitive impairment without dementia during a 5-year follow-up. +1 more finding

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

The link between childhood trauma and depression: insights from HPA axis studies in humans

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Psychoneuroendocrinology

Key finding: We here summarize results from a series of clinical studies suggesting that childhood trauma in humans is associated with sensitization of the neuroendocrine stress response, glucocorticoid resistance, increased central corticotropin-releasing factor (CRF) activity, immune activation, and reduced hippocampal volume, closely paralleling several of the neuroendocrine features of depression. +2 more findings

Full summary, score breakdown and related studies → Original source

Dementia and dysphagia

36/100 ✓ Peer-reviewed Clinical safety Geriatric nursing (New York, N.Y.)

Key finding: Dysphagia can be a result of behavioral, sensory, or motor problems (or a combination of these) and is common in individuals with neurologic disease and dementia. +1 more finding

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New therapeutic targets in the neurovascular pathway in Alzheimer's disease

36/100 ✓ Peer-reviewed Disease mechanisms Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Key finding: Recent findings indicate that neurovascular dysfunction is an integral part of Alzheimer's disease (AD). +1 more finding

• Brain Biology
• Treatments

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Tauopathy with paired helical filaments in an aged chimpanzee

41/100 ✓ Peer-reviewed Disease mechanisms The Journal of comparative neurology

Key finding: Sequencing of the exons and flanking intronic regions in the genomic MAPT locus disclosed no mutations that are associated with the known human hereditary tauopathies, nor any polymorphisms of obvious functional significance. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

P3‐482: Creation and implementation of the nation's first Alzheimer's disease advantage plan

24/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: Members enrolling in this new plan are intensively co-managed by the medical team and the identified case manager. +4 more findings

• Caregiving
• Policy

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Traumatic Brain Injury and Cognitive Rehabilitation: Current Approaches to Research, Reimbursement, and Clinical Treatment

42/100 ✓ Peer-reviewed Risk factors ASHA Leader

Key finding: The existing evidence suggests that both could be addressed with either antecedent behavior management strategies, such as creating verbal scripts and routines (e.g., an “escape” routine when he is losing his temper, greeting routines for customers), or consequence-oriented management such as reinforcement of either positive behaviors or low rates of negative behaviors (Ylvisaker, Turkstra, & Coelho, 2005). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

45/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry

Key finding: In this study, we evaluated the cognitive performance in rodent models of hypercholesterolemia in relation to neuroinflammatory changes and amyloid precursor protein (APP) processing, the two key parameters of Alzheimer's disease pathogenesis. +3 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI

41/100 ✓ Peer-reviewed Tau biomarkers Journal of the International Neuropsychological Society : JINS

Key finding: Mild cognitive impairment (MCI) is regarded as the prodromal stage of dementia disorders, such as Alzheimer's disease (AD). +3 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing

41/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry

Key finding: The proteolytic cleavage of the amyloid precursor protein (APP) through the alpha-secretase pathway decreases in AD, concurrent with cognitive impairment. +3 more findings

• Treatments

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Mild cognitive impairment in the general population: occurrence and progression to Alzheimer disease

46/100 ✓ Peer-reviewed Mild cognitive impairment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Two-thirds of MCI-multidomains, but only half of MCI-amnestic progress to AD.

• Early Stage

Full summary, score breakdown and related studies → Original source

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

54/100 ✓ Peer-reviewed Lewy body dementia Annals of neurology

Key finding: These results suggest that phosphorylated TDP-43 is a major component of the inclusions, and that abnormal phosphorylation of TDP-43 is a critical step in the pathogenesis of FTLD-U and ALS. +1 more finding

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients

51/100 ✓ Peer-reviewed How common it is The Journal of trauma

Key finding: Approximately 7 of 10 SICU and TICU patients experience delirium. +1 more finding

• Risk Factors

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Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

71/100 ✓ Peer-reviewed How common it is Lancet (London, England)

Key finding: 20 participants--15 in the AN1792 group, five in the placebo group--died before follow-up started. +1 more finding

• Clinical Trials
• Brain Biology

Full summary, score breakdown and related studies → Original source

The attitudes and practices of general practitioners regarding dementia diagnosis in Ireland

46/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry

Key finding: Future educational supports for GPs need to be developed which concentrate on these areas.

• Diagnosis

Full summary, score breakdown and related studies → Original source

Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline

49/100 ✓ Peer-reviewed Caregiving Neurology

Key finding: Increased total and periventricular (PV) white matter hyperintensity (WMH) burden and progression of PV WMH burden are associated with decreased gait performance over time, while progression of subcortical WMH volume is associated with memory decline in cognitively intact elderly. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Cardiorespiratory fitness and brain atrophy in early Alzheimer disease

55/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Increased cardiorespiratory fitness is associated with reduced brain atrophy in Alzheimer disease (AD). +4 more findings

• Brain Scans
• Lifestyle

Full summary, score breakdown and related studies → Original source

Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence

52/100 ✓ Peer-reviewed Getting a diagnosis The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Imbalances between cholinergic and other neurotransmitter pathways may result in delirium.

Full summary, score breakdown and related studies → Original source

Animal models of Alzheimer's disease and frontotemporal dementia

47/100 ✓ Peer-reviewed Getting a diagnosis Nature reviews. Neuroscience

Key finding: Recent work in transgenic mice has shed light on the role of these aggregates by identifying soluble oligomeric species that may interfere with essential cellular mechanisms at an early disease stage. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source