Newest studies

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

59/100 ✓ Peer-reviewed Cognitive tests and assessment BMJ

Key finding: David Moher and colleagues introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses

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How citation distortions create unfounded authority: analysis of a citation network

43/100 ✓ Peer-reviewed Drug development BMJ (Clinical research ed.)

Key finding: Citation is both an impartial scholarly method and a powerful form of social communication.

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Cognitive impairment predicts poststroke death in long-term follow-up

51/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry

Key finding: Whether deficits in specific cognitive domains are associated with long-term survival in patients with ischaemic stroke is not known in detail. +2 more findings

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The pharmacology of sigma-1 receptors

36/100 ✓ Peer-reviewed Brain scans and imaging Pharmacology & therapeutics

Key finding: We found that the most prominent action of sigma-1 receptors in biological systems including cell lines, primary cultures, and animals is the regulation and modulation of voltage-regulated and ligand-gated ion channels, including Ca(2+)-, K(+)-, Na(+), Cl(-), and SK channels, and NMDA and IP3 receptors. +2 more findings

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(-)-epigallocatechin-3-gallate (EGCG) maintains kappa-casein in its pre-fibrillar state without redirecting its aggregation pathway

36/100 ✓ Peer-reviewed Treatments Journal of molecular biology

Key finding: EGCG redirects the aggregation of these polypeptides to a disordered off-folding pathway that results in the formation of non-toxic amorphous aggregates. +1 more finding

• Brain Biology

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Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease

41/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: (18)F-flutemetamol uptake can be readily quantified. +2 more findings

• Clinical Trials

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What do community-dwelling people with dementia need? A survey of those who are known to care and welfare services

44/100 ✓ Peer-reviewed Caregiving International psychogeriatrics

Key finding: This study showed a large number of unmet needs in dementia. +1 more finding

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Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry: an ADNI study of 515 subjects

57/100 ✓ Peer-reviewed Cognitive tests and assessment NeuroImage

Key finding: We optimized a TBM-based image analysis method to determine what methodological factors, and which image-derived measures, maximize statistical power to track brain change. 3D maps, tracking rates of structural atrophy over time, were created from 1030 longitudinal brain MRI scans (1-year follow-up) of 104 AD patients (age: 75.7+/-7.2 years; MMSE: 23.3+/-1.8, at baseline), 254 amnestic MCI subjects (75.0+/-7.2 years; 27.0+/-1.8), and 157 healthy elderly subjects (75.9+/-5.1 years; 29.1+/-1.0), as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI). +3 more findings

• Early Stage

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A novel pathway for amyloid precursor protein processing

38/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging

Key finding: Using immunoprecipitation and mass spectrometry we have shown that Aβ is present in cerebrospinal fluid (CSF) as several shorter isoforms in addition to Aβ1-40 and Aβ1-42. +3 more findings

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Primary Care Physicians' Dementia Care Practices: Evidence of Geographic Variation

44/100 ✓ Peer-reviewed Risk factors The Gerontologist

Key finding: Nearly 90% of PCPs prescribed donepezil in the previous year for their dementia patients. +4 more findings

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Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production

41/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: In several studies APP has recently been shown to form homodimers, and this event appears to influence Abeta generation. +3 more findings

• Brain Biology

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The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

57/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America

Key finding: Down syndrome (DS), or trisomy 21, is a common disorder associated with several complex clinical phenotypes.

• Down Syndrome
• Genetics

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Early parental care is important for hippocampal maturation: evidence from brain morphology in humans

52/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

Key finding: Parental nurturance at age 4 predicts the volume of the left hippocampus in adolescence, with better nurturance associated with smaller hippocampal volume. +2 more findings

• Brain Scans

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Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study

56/100 ✓ Peer-reviewed Genetics Neurology

Key finding: PIB-positive subjects with mild cognitive impairment (MCI) are significantly more likely to convert to AD than PIB-negative patients, faster converters having higher PIB retention levels at baseline than slower converters. +3 more findings

• Genetics
• Brain Scans
• Early Stage

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Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

59/100 ✓ Peer-reviewed Vascular contributions BMJ (Clinical research ed.)

Key finding: The three year results of the LADIS study suggest that in older adults who seek medical attention for non-disabling complaints, severe age related changes in white matter independently and strongly predict rapid global functional decline. +2 more findings

• Risk Factors

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Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche

55/100 ✓ Peer-reviewed Vascular contributions PubMed

Key finding: G) Functions, such as vessel stabilization, regulation of vascular tone and maintenance of local and tissue homeostasis (contractile capacity and vessel permeability regulation), matrix protein synthesis, macrophage-like properties, immunological defense, intervention in coagulation, participation in mechanisms that regulate the quiescent and angiogenic stages of blood vessels (including the behaviour of pericytes during sprouting angiogenesis and intussuceptive vascular growth, as well as pericyte interactions with endothelium and other cells, and with extracellular matrix) and plasticity, as progenitor cells with great mesenchymal potential, originating other pericytes, fibroblast/myofibroblasts, preadipocytes, chondroblasts, osteoblasts, odontoblasts, vascular smooth muscle and myointimal cells. +4 more findings

• Risk Factors

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Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: In vitro evidence suggests that amyloid-beta (A beta) contributes to BDNF downregulation in AD, but the specific A beta aggregation state responsible for this downregulation in vivo is unknown. +2 more findings

• Brain Biology

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The association between dementia and long-term use of benzodiazepine in the elderly: nested case-control study using claims data

59/100 ✓ Peer-reviewed Digital health tools The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Our findings suggest that long-term use of BZDs is associated with an increased risk for dementia, but the underlying mechanisms remain unclear, and further investigations are needed. +2 more findings

• Side Effects
• Risk Factors

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Clinical and cost effectiveness of services for early diagnosis and intervention in dementia

36/100 ✓ Peer-reviewed Costs and economics International journal of geriatric psychiatry

Key finding: The new services would cost around pound sterling 220 million extra per year nationally in England. +2 more findings

• Policy
• Diagnosis

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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: We found that mitochondria were redistributed away from axons in the pyramidal neurons of AD brain. +3 more findings

• Brain Biology

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Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin

36/100 ✓ Peer-reviewed Prevention and risk The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Here, we report Abeta oligomers significantly increased active JNK and phosphorylation of IRS-1 (Ser616) and tau (Ser422) in cultured hippocampal neurons, whereas JNK inhibition blocked these responses. +1 more finding

• Brain Biology
• Lifestyle

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Elevated serum pesticide levels and risk of Parkinson disease

57/100 ✓ Peer-reviewed Risk factors Archives of neurology

Key finding: These data suggest that beta-HCH is associated with a diagnosis of PD. +3 more findings

• Other Dementias

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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

36/100 ✓ Peer-reviewed Risk factors Nature chemistry

Key finding: We applied these methods to a number of the amyloid-β protein isoforms of Aβ40 and Aβ42 and showed that their oligomer-size distributions are very different. +1 more finding

• Brain Biology

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Disclosure of APOE genotype for risk of Alzheimer's disease

74/100 ✓ Peer-reviewed Clinical trials The New England journal of medicine

Key finding: The disclosure of APOE genotyping results to adult children of patients with Alzheimer's disease did not result in significant short-term psychological risks. +4 more findings

• Genetics
• Clinical Trials
• Risk Factors

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Capturing the costs of end-of-life care: comparisons of multiple sclerosis, Parkinson's disease, and dementia

36/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: What is clear is that the costs of providing end-of-life care can be high and that informal care from family members and friends accounts for a substantial amount of the overall costs.

• End-of-Life Care
• Policy
• Other Dementias

Full summary, score breakdown and related studies → Original source