Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,226–23,250 of 27,380 studies, newest first · page 930 of 1096.
March 2006 25
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2006-03-01
Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease
43/100 ✓ Peer-reviewed Drug development Nature clinical practice. Neurology
Key finding: A number of well-designed epidemiological studies have linked type 2 diabetes mellitus (T2DM) with an increased risk of Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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2006-03-01
Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life
59/100 ✓ Peer-reviewed Treatments Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Key finding: Cognitive functioning, mood, and health-related QOL were significantly improved following a 24-week course of the acetylcholinesterase inhibitor donepezil. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease
43/100 ✓ Peer-reviewed Brain scans and imaging Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
Key finding: Our study confirms some other studies in showing that in AD patients there is a reduction of parapapillary and macular RNFL thickness and macular volume as measured by OCT. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
40/100 ✓ Peer-reviewed Tau biomarkers FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Key finding: Using this ELISA, we report the presence of significantly elevated (P=0.002) levels of oligomeric forms of alpha-syn in plasma samples obtained from 34 PD patients compared with 27 controls; 52% (95% confidence intervals 0.353-0.687) of the PD patients displayed signals >0.5 OD with our ELISA assay in comparison to only 14.8% (95% confidence intervals 0.014-0.281) for the control cases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-03-01
Elevation in plasma Abeta42 in geriatric depression: a pilot study
36/100 ✓ Peer-reviewed Biomarkers Neurochemical research
Key finding: Elevated plasma amyloid beta 1-42 (Abeta42) level has been linked to increased risk for incident AD in cognitively-intact elderly. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease
36/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: The cascade of Alzheimer's disease (AD) neurodegeneration is associated with persistent oxidative stress, mitochondrial dysfunction, impaired energy metabolism, and activation of pro-death signaling pathways. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives
45/100 ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry
Key finding: Schizophrenia and psychotic bipolar disorder are characterized by morphometric distinctions in ventricular and hippocampal regions.
Full summary, score breakdown and related studies → Original source
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2006-03-01
Is hospice associated with improved end-of-life care in nursing homes and assisted living facilities?
44/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Rates of hospice use observed in this study (22%) were considerably higher than previously reported, although persons with dementia may continue to be underreferred. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-03-01
Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study
45/100 ✓ Peer-reviewed Clinical safety The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: Our findings show an association between low circulating levels of one of the most important components of the human antioxidant system and the presence of frailty. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Cognitive processes related to gait velocity: results from the Einstein Aging Study
36/100 ✓ Peer-reviewed Clinical safety Neuropsychology
Key finding: Regression analyses revealed that these factors were significant predictors of variance in gait velocity, but the relationship varied as a function of task condition. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-03-01
Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials
74/100 ✓ Peer-reviewed Clinical safety The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Quality of the reporting of trials varied. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology
Key finding: However, in most of DLB cases, LBs are associated with neurofibrillary tangles and amyloid plaques (both Alzheimer disease [AD]-related lesions). +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: We conclude that protein tau plays an important beneficial role in normal neuronal processes of hippocampal memory, and conversely, that not tau mutations per se, but the ensuing hyperphosphorylation must be critical for cognitive decline in tauopathies.
Full summary, score breakdown and related studies → Original source
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2006-03-01
Interface between tauopathies and synucleinopathies: a tale of two proteins
40/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology
Key finding: This overlap extends to the neuropathological findings; the pathognomonic hallmark for one set of disorders, Lewy bodies or neurofibrillary tangles, is present more often than expected in the other set. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
[Biochemical markers for Alzheimer disease]
37/100 ✓ Peer-reviewed Tau biomarkers Ugeskrift for laeger
Key finding: Symptomatic treatment now exists which can temporarily inhibit the loss of brain function. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Neurobiological studies of dementia--biological markers and neuroprotective strategies for Alzheimer disease
27/100 ✓ Peer-reviewed Tau biomarkers Acta neurologica Taiwanica
Key finding: Total tau protein in CSF is a biomarker for AD, however increased levels of total tau in CSF were also observed in other neurological disease with dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Astaxanthin, a carotenoid with potential in human health and nutrition
42/100 ✓ Peer-reviewed Risk factors Journal of natural products
Key finding: The potent antioxidant property of 1 has been implicated in its various biological activities demonstrated in both experimental animals and clinical studies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-03-01
Neurobiology of exercise
51/100 ✓ Peer-reviewed Risk factors Obesity (Silver Spring, Md.)
Key finding: These adaptations in the central nervous system have implications for the prevention and treatment of obesity, cancer, depression, the decline in cognition associated with aging, and neurological disorders such as Parkinson's disease, Alzheimer's dementia, ischemic stroke, and head and spinal cord injury.
Full summary, score breakdown and related studies → Original source
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2006-03-01
Neuropsychiatric symptoms as a predictor of caregiver burden in Alzheimer's disease
45/100 ✓ Peer-reviewed Caregiving Neuropsychiatric disease and treatment
Key finding: No correlation with neuropsychiatric symptoms such as apathy and depression was found. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-03-01
Education and rates of cognitive decline in incident Alzheimer's disease
63/100 ✓ Peer-reviewed Caregiving Journal of neurology, neurosurgery, and psychiatry
Key finding: We conclude that higher education AD patients experience faster cognitive decline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study
69/100 ✓ Peer-reviewed Getting a diagnosis Archives of general psychiatry
Key finding: Depressive symptoms were associated with increased risk of MCI, and this association was independent of underlying vascular disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-03-01
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
58/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology
Key finding: These observations suggest that brain amyloid deposition results in low CSF Abeta(42), and that amyloid imaging and CSF Abeta(42) may potentially serve as antecedent biomarkers of (preclinical) AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-03-01
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
59/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: During follow-up, 57 (42%) patients with MCI developed Alzheimer's disease, 21 (15%) developed other forms of dementia, and 56 (41%) remained cognitively stable for 5.2 years (range 4.0-6.8).
Full summary, score breakdown and related studies → Original source
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2006-03-01
Poor sleep is associated with higher plasma proinflammatory cytokine interleukin-6 and procoagulant marker fibrin D-dimer in older caregivers of people with Alzheimer's disease
49/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society
Key finding: These effects were most pronounced in caregivers of subjects with Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2006-03-01
Risperidone in the treatment of psychosis of Alzheimer disease: results from a prospective clinical trial
64/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Efficacy analysis included 416 patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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