Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,476–20,500 of 27,380 studies, newest first · page 820 of 1096.
November 2010 16
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2010-11-01
Dementia and hip fractures: development of a pathogenic framework for understanding and studying risk
36/100 ✓ Peer-reviewed Clinical safety Geriatric orthopaedic surgery & rehabilitation
Key finding: Dementia and hip fractures are 2 conditions that are seen primarily in older adults, and both are associated with substantial morbidity and mortality.
Full summary, score breakdown and related studies → Original source
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2010-11-01
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: The hypothesis that amyloid-β (Aβ) peptides are the primary causative agents of AD retains significant support among researchers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-11-01
Palliative Care for Patients with Dementia: A National Survey
41/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: Ninety-four percent of hospices and 72% of PC programs had served at least one patient with a primary diagnosis of dementia within the past year. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
A recommended scale for cognitive screening in clinical trials of Parkinson's disease
46/100 ✓ Peer-reviewed Cognitive tests and assessment Movement disorders : official journal of the Movement Disorder Society
Key finding: There is a critical need for a brief, standard cognitive screening measure for use in PD trials whose primary focus is not on cognition. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Amyloid imaging of Lewy body-associated disorders
55/100 ✓ Peer-reviewed Mild cognitive impairment Movement disorders : official journal of the Movement Disorder Society
Key finding: Regional PIB BPs and the proportion of individuals with abnormally elevated MCBP were not significantly different across participant groups. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin
53/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: In the CNS, Sortilin is expressed by neurons and PGRN is most strongly expressed by activated microglial cells after injury. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Change in plasma Aß peptides and onset of dementia in adults with Down syndrome
54/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology
Key finding: Among adults with DS, decreasing levels of plasma Aβ42, a decline in the Aβ42/Aβ40 ratio, or increasing levels of Aβ40 may be sensitive indicators of conversion to AD, possibly reflecting compartmentalization of Aβ peptides in the brain. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease
60/100 ✓ Peer-reviewed How common it is Biological psychiatry
Key finding: These data demonstrate that YKL-40, a putative indicator of neuroinflammation, is elevated in AD and, together with Aβ42, has potential prognostic utility as a biomarker for preclinical AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
47/100 ✓ Peer-reviewed Caregiving Molecular neurodegeneration
Key finding: Neuroprotection alone is not sufficient to rescue tau-induced memory loss in a transgenic mouse model. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Impact of early onset dementia on caregivers: a review
44/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: Whether there is a difference in impact between EOD and LOD on caregivers is still unclear. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Imaging correlates of pathology in corticobasal syndrome
61/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Imaging patterns of atrophy in CBS vary according to pathologic diagnosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
50/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology
Key finding: White matter hyperintensity volume predicts 1-year cognitive decline in a relatively healthy convenience sample that was similar to clinical trial samples, and therefore should be considered as a covariate of interest at baseline and longitudinally in future AD treatment trials. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Loss of 'small-world' networks in Alzheimer's disease: graph analysis of FMRI resting-state functional connectivity
56/100 ✓ Peer-reviewed Brain scans and imaging PloS one
Key finding: We present evidence of AD-induced changes in global brain functional connectivity specifically affecting long-distance connectivity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-11-01
The MoCA: well-suited screen for cognitive impairment in Parkinson disease
58/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Primary outcomes using receiver operating characteristic (ROC) curve analyses showed that all 3 mental status tests produced excellent discrimination of PD-D from patients without dementia (area under the curve [AUC], 87%-91%) and PD-MCI from PD-N patients (AUC, 78%-90%), but the MoCA was generally better suited across both assessments.
Full summary, score breakdown and related studies → Original source
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2010-11-01
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial
80/100 ✓ Peer-reviewed Treatments JAMA
Key finding: Epidemiological studies suggest that consumption of DHA is associated with a reduced incidence of Alzheimer disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study
65/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Our findings suggest that insulin metabolism influences the clinical manifestation of AD only within 3 years. +4 more findings
Full summary, score breakdown and related studies → Original source
October 2010 9
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2010-10-30
Inflammation and Alzheimer's disease
43/100 ✓ Peer-reviewed Inflammation and the immune system Archives of pharmacal research
Key finding: It is characterized by extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-29
Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease
45/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: NPS are common even in the early stages of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-28
Review of effects of physical activity on strength, balance, mobility and ADL performance in elderly subjects with dementia
36/100 ✓ Peer-reviewed Prevention trials Dementia and geriatric cognitive disorders
Key finding: Multicomponent interventions can improve physical functioning and BADL in elderly subjects regardless of the stage of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-10-27
Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects
61/100 ✓ Peer-reviewed Genetics Neurology
Key finding: A slower rate of hippocampal atrophy in normal APOE2 carriers is consistent with the lower risk of Alzheimer disease in these individuals. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-26
Enhancing dementia care: a primary care-based memory clinic
48/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: The results indicate that memory clinics within primary care settings can support capacity building to ensure quality assessment and management of dementia at a primary care level.
Full summary, score breakdown and related studies → Original source
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2010-10-26
β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease
44/100 ✓ Peer-reviewed Risk genes beyond APOE Free radical biology & medicine
Key finding: The abnormal interactions of Aβ with metal ions such as iron are implicated in the process of Aβ deposition and oxidative stress in AD brains. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-25
Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia
53/100 ✓ Peer-reviewed Vascular contributions Archives of internal medicine
Key finding: In this large cohort, heavy smoking in midlife was associated with a greater than 100% increase in risk of dementia, AD, and VaD more than 2 decades later. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-25
Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies
73/100 ✓ Peer-reviewed Cognitive tests and assessment The Lancet. Neurology
Key finding: We investigated the effects of renin-angiotensin system blockade on cognitive function in patients aged 55 years and older with established atherosclerotic cardiovascular disease or diabetes with end-organ damage in two clinical trials. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-10-22
Smoking Characteristics of Adults With Selected Lifetime Mental Illnesses: Results From the 2007 National Health Interview Survey
43/100 ✓ Peer-reviewed Prevention and risk American Journal of Public Health
Key finding: The age-adjusted smoking prevalence of adults with mental illness or serious psychological distress ranged from 34.3% (phobias or fears) to 59.1% (schizophrenia) compared with 18.3% of adults with no such illness. +4 more findings
Full summary, score breakdown and related studies → Original source
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