Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,976–27,000 of 27,380 studies, newest first · page 1080 of 1096.
January 1991 13
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1991-01-01
Association of deep white matter infarction with chronic communicating hydrocephalus: implications regarding the possible origin of normal-pressure hydrocephalus
47/100 ✓ Peer-reviewed Digital health tools PubMed Central
Key finding: The purpose of this MR study was to determine if the two diseases demonstrated a statistical association. +4 more findings
Full summary, score breakdown and related studies → Original source
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1991-01-01
COGNITIVE IMPAIRMENT IN EARLY, UNTREATED PARKINSON'S DISEASE AND ITS RELATIONSHIP TO MOTOR DISABILITY
62/100 ✓ Peer-reviewed Risk factors Brain
Key finding: The results indicate dissociation of cognition and motor control in early PD which suggests that cognitive dysfunction is largely independent of frontostriatal dopamine deficiency underlying motor disability.
Full summary, score breakdown and related studies → Original source
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1991-01-01
Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease
40/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: The hippocampus and entorhinal cortex (parahippocampal gyrus) showed significant atrophy, with over 40% reduction in size. +1 more finding
Full summary, score breakdown and related studies → Original source
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1991 year only
Out of pocket expenditures by family caregivers of dementia patients residing in the community
46/100 ✓ Peer-reviewed Costs and economics Home health care services quarterly
Key finding: Out of pocket expenditures by families (N = 182) of relatives with dementia residing in the community were examined. +2 more findings
Full summary, score breakdown and related studies → Original source
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1991-01-01
Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site
36/100 ✓ Peer-reviewed Drug development The Biochemical journal
Key finding: The ultrastructural appearance of the immunolabelling suggested that both the N- and C-terminal domains of tau extend outwards from the axis of PHF. +2 more findings
Full summary, score breakdown and related studies → Original source
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1991-01-01
Visual dysfunction in Alzheimer's disease: relation to normal aging
40/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology
Key finding: In patients with Alzheimer's disease (AD), compared with age-matched and young healthy control subjects, visual deficits in the following functions were observed: color, stereoacuity, contrast sensitivity, and backward masking (homogeneous and pattern). +1 more finding
Full summary, score breakdown and related studies → Original source
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1991 no date recorded — placed by publication year
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
49/100 ✓ Peer-reviewed Disease mechanisms Trends in Pharmacological Sciences
Full summary, score breakdown and related studies → Original source
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1991 no date recorded — placed by publication year
The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease
47/100 ✓ Peer-reviewed Brain tissue and pathology Cerebral Cortex
The distribution of neurofibrillary tangles (NFTs) and neuritic plaques (NPs) was mapped in 39 cortical areas of 11 brains of patients with Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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1991-01-01
Epidemiology of Multi-Infarct Dementia
33/100 ✓ Peer-reviewed Risk factors Alzheimer Disease & Associated Disorders
Key finding: Multi-infarct dementia (MID), thought to result from the cumulative effect of repeated episodes of cerebral infarction, represents a sizable proportion of the dementia cases in the population. +1 more finding
Full summary, score breakdown and related studies → Original source
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1991-01-01
Measurement of amyloid peptide precursor of Alzheimer disease in human blood by double antibody immunoradiometric assay
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer disease and associated disorders
Key finding: The dementia of Alzheimer disease (AD) correlates with the deposition of extracellular amyloid, and this amyloid arises from the abnormal processing of a high molecular weight amyloid peptide precursor (APP), which is a normal cellular protein that is found in both brain and in peripheral tissues in humans.
Full summary, score breakdown and related studies → Original source
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1991-01-01
Familial Alzheimer disease: a large, multigeneration German kindred
32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer disease and associated disorders
Key finding: Ancestors were traced through seven generations to a couple residing in East-Westfalia during the middle of the 19th century. +4 more findings
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1991-01-01
Expression of human Cu-Zn superoxide dismutase gene in transgenic mice: model for gene dosage effect in Down syndrome
37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical research communications
Key finding: It was suggested that increased Cu-Zn superoxide dismutase (SOD-1) might be involved in the various biological abnormalities found in Down's syndrome (DS) such as premature aging and Alzheimer-type neurological lesions. +1 more finding
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1991-01-01
Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group
55/100 ✓ Peer-reviewed Risk factors International journal of epidemiology
Key finding: To increase comparability of studies, exposures were limited to head trauma with loss of consciousness (hereafter referred to as 'head trauma') and comparisons were restricted to community (versus hospital) controls. +4 more findings
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December 1990 5
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1990-12-15
Clarifying Confusion: The Confusion Assessment Method
51/100 ✓ Peer-reviewed Cognitive tests and assessment Annals of Internal Medicine
The CAM is sensitive, specific, reliable, and easy to use for identification of delirium.
Full summary, score breakdown and related studies → Original source
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1990-12-01
The Clinical Efficacy of Citalopram in Treatment of Emotional Disturbances in Dementia Disorders a Nordic Multicentre Study
43/100 ✓ Peer-reviewed Clinical trials The British Journal of Psychiatry
Key finding: Patients with AD/SDAT treated with citalopram showed a significant improvement in emotional bluntness, confusion, irritability, anxiety, fear/panic, depressed mood and restlessness. +1 more finding
Full summary, score breakdown and related studies → Original source
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1990-12-01
Induction and regulation of interleukin-6 gene expression in rat astrocytes
41/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmunology
Key finding: It is now established that astrocytes produce IL-6; however, the precise inducing molecules and the kinetics of their action have not yet been clearly identified. +3 more findings
Full summary, score breakdown and related studies → Original source
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1990-12-01
Cerebral blood flow and oxygen metabolism in patients with vascular dementia of the Binswanger type
39/100 ✓ Peer-reviewed Digital health tools Stroke
Key finding: Digital subtraction angiography of the cervical and intracranial arteries demonstrated no occlusive lesion in any patient. +1 more finding
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1990-12-01
Glial fibrillary acidic protein and beta A4 protein deposits in temporal lobe of aging brain and senile dementia of the Alzheimer type: relation with the cognitive state and with quantitative studies of senile plaques and neurofibrillary tangles
38/100 ✓ Peer-reviewed Biomarkers Journal of neuroscience research
Key finding: A significant correlation between the BTS and the amount of GFAP could be found only when using the non parametric test of Spearman. +2 more findings
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November 1990 6
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1990-11-01
Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer's disease and aging
36/100 ✓ Peer-reviewed Drug development Neuroscience letters
Key finding: Neocortical neurofibrillary tangles (NFT) revealed by Bodian technique and anti-tau immunolabelling were seen in 5/5 cases of progressive supranuclear palsy (PSP) aged 58-76 years.
Full summary, score breakdown and related studies → Original source
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1990-11-01
A MODEL FOR THE MANAGEMENT OF PEOPLE WITH DIAGNOSED DEMENTIA IN COUNTRY AREAS
29/100 ✓ Peer-reviewed Health systems and care delivery Australasian Journal on Ageing
Key finding: The aged population explosion along the Mid‐north Coastal fringe (increases of 39% in some areas) has identified a need for some form of programme to address the problems associated with the maintenance of clients diagnosed with dementia in the community for as long as possible.
Full summary, score breakdown and related studies → Original source
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1990-11-01
Brain microglia constitutively express beta-2 integrins
44/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmunology
Key finding: Resting microglia were found to express constitutively CD11a (LFA-1), CD11b (Mac-1, CR3), CD11c (P150, 95; CR4), and CD18 (beta-2). +3 more findings
Full summary, score breakdown and related studies → Original source
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1990-11-01
Identification of nuclear tau isoforms in human neuroblastoma cells
42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: This work indicates that tau may function in processes not directly associated with microtubules and that highly insoluble complexes of tau may also play a role in normal cellular physiology.
Full summary, score breakdown and related studies → Original source
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1990-11-01
A case-control study of Alzheimer's disease in Australia
59/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: Significant odds ratios were found for 4 variables: a history of either dementia, probable AD, or Down's syndrome in a 1st-degree relative, and underactivity as a behavioral trait in both the recent and more distant past.
Full summary, score breakdown and related studies → Original source
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1990-11-01
Slowly progressive aphasia: three cases with language, memory, CT and PET data
44/100 ✓ Peer-reviewed Digital health tools Journal of neurology, neurosurgery, and psychiatry
Key finding: The data suggest that the syndrome of "progressive aphasia": 1) does not involve a uniform symptom complex; 2) does not necessarily develop into a full blown dementia syndrome; 3) varies greatly in rate of progression from case to case; 4) is associated with normal brain structure (on computer tomography); and 5) is associated with abnormal left temporal lobe metabolism as measured by fluorodeoxyglucose (FDG) positron emission tomography (PET).
Full summary, score breakdown and related studies → Original source
October 1990 1
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1990-10-01
Caregiving and the Stress Process: An Overview of Concepts and Their Measures
51/100 ✓ Peer-reviewed Caregiving The Gerontologist
This paper views caregiver stress as a consequence of a process comprising a number of interrelated conditions, including the socioeconomic characteristics and resources of caregivers and the primary and secondary stressors to which they are exposed.
Full summary, score breakdown and related studies → Original source
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