Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 26,976–27,000 of 27,380 studies, newest first · page 1080 of 1096.

January 1991 13

  1. 1991-01-01
  2. 1991-01-01

    COGNITIVE IMPAIRMENT IN EARLY, UNTREATED PARKINSON'S DISEASE AND ITS RELATIONSHIP TO MOTOR DISABILITY

    ✓ Peer-reviewed Risk factors Brain

    Key finding: The results indicate dissociation of cognition and motor control in early PD which suggests that cognitive dysfunction is largely independent of frontostriatal dopamine deficiency underlying motor disability.

  3. 1991-01-01

    Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: The hippocampus and entorhinal cortex (parahippocampal gyrus) showed significant atrophy, with over 40% reduction in size. +1 more finding

  4. 1991 year only

    Out of pocket expenditures by family caregivers of dementia patients residing in the community

    ✓ Peer-reviewed Costs and economics Home health care services quarterly

    Key finding: Out of pocket expenditures by families (N = 182) of relatives with dementia residing in the community were examined. +2 more findings

  5. 1991-01-01

    Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

    ✓ Peer-reviewed Drug development The Biochemical journal

    Key finding: The ultrastructural appearance of the immunolabelling suggested that both the N- and C-terminal domains of tau extend outwards from the axis of PHF. +2 more findings

  6. 1991-01-01

    Visual dysfunction in Alzheimer's disease: relation to normal aging

    ✓ Peer-reviewed Brain scans and imaging Annals of neurology

    Key finding: In patients with Alzheimer's disease (AD), compared with age-matched and young healthy control subjects, visual deficits in the following functions were observed: color, stereoacuity, contrast sensitivity, and backward masking (homogeneous and pattern). +1 more finding

  7. 1991 no date recorded — placed by publication year
  8. 1991 no date recorded — placed by publication year

    The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

    ✓ Peer-reviewed Brain tissue and pathology Cerebral Cortex

    The distribution of neurofibrillary tangles (NFTs) and neuritic plaques (NPs) was mapped in 39 cortical areas of 11 brains of patients with Alzheimer's disease (AD).

  9. 1991-01-01

    Epidemiology of Multi-Infarct Dementia

    ✓ Peer-reviewed Risk factors Alzheimer Disease & Associated Disorders

    Key finding: Multi-infarct dementia (MID), thought to result from the cumulative effect of repeated episodes of cerebral infarction, represents a sizable proportion of the dementia cases in the population. +1 more finding

  10. 1991-01-01

    Measurement of amyloid peptide precursor of Alzheimer disease in human blood by double antibody immunoradiometric assay

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer disease and associated disorders

    Key finding: The dementia of Alzheimer disease (AD) correlates with the deposition of extracellular amyloid, and this amyloid arises from the abnormal processing of a high molecular weight amyloid peptide precursor (APP), which is a normal cellular protein that is found in both brain and in peripheral tissues in humans.

  11. 1991-01-01

    Familial Alzheimer disease: a large, multigeneration German kindred

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer disease and associated disorders

    Key finding: Ancestors were traced through seven generations to a couple residing in East-Westfalia during the middle of the 19th century. +4 more findings

  12. 1991-01-01

    Expression of human Cu-Zn superoxide dismutase gene in transgenic mice: model for gene dosage effect in Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical research communications

    Key finding: It was suggested that increased Cu-Zn superoxide dismutase (SOD-1) might be involved in the various biological abnormalities found in Down's syndrome (DS) such as premature aging and Alzheimer-type neurological lesions. +1 more finding

  13. 1991-01-01

    Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group

    ✓ Peer-reviewed Risk factors International journal of epidemiology

    Key finding: To increase comparability of studies, exposures were limited to head trauma with loss of consciousness (hereafter referred to as 'head trauma') and comparisons were restricted to community (versus hospital) controls. +4 more findings

December 1990 5

  1. 1990-12-15

    Clarifying Confusion: The Confusion Assessment Method

    ✓ Peer-reviewed Cognitive tests and assessment Annals of Internal Medicine

    The CAM is sensitive, specific, reliable, and easy to use for identification of delirium.

  2. 1990-12-01

    The Clinical Efficacy of Citalopram in Treatment of Emotional Disturbances in Dementia Disorders a Nordic Multicentre Study

    ✓ Peer-reviewed Clinical trials The British Journal of Psychiatry

    Key finding: Patients with AD/SDAT treated with citalopram showed a significant improvement in emotional bluntness, confusion, irritability, anxiety, fear/panic, depressed mood and restlessness. +1 more finding

  3. 1990-12-01

    Induction and regulation of interleukin-6 gene expression in rat astrocytes

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmunology

    Key finding: It is now established that astrocytes produce IL-6; however, the precise inducing molecules and the kinetics of their action have not yet been clearly identified. +3 more findings

  4. 1990-12-01

    Cerebral blood flow and oxygen metabolism in patients with vascular dementia of the Binswanger type

    ✓ Peer-reviewed Digital health tools Stroke

    Key finding: Digital subtraction angiography of the cervical and intracranial arteries demonstrated no occlusive lesion in any patient. +1 more finding

  5. 1990-12-01

November 1990 6

  1. 1990-11-01

    Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer's disease and aging

    ✓ Peer-reviewed Drug development Neuroscience letters

    Key finding: Neocortical neurofibrillary tangles (NFT) revealed by Bodian technique and anti-tau immunolabelling were seen in 5/5 cases of progressive supranuclear palsy (PSP) aged 58-76 years.

  2. 1990-11-01

    A MODEL FOR THE MANAGEMENT OF PEOPLE WITH DIAGNOSED DEMENTIA IN COUNTRY AREAS

    ✓ Peer-reviewed Health systems and care delivery Australasian Journal on Ageing

    Key finding: The aged population explosion along the Mid‐north Coastal fringe (increases of 39% in some areas) has identified a need for some form of programme to address the problems associated with the maintenance of clients diagnosed with dementia in the community for as long as possible.

  3. 1990-11-01

    Brain microglia constitutively express beta-2 integrins

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmunology

    Key finding: Resting microglia were found to express constitutively CD11a (LFA-1), CD11b (Mac-1, CR3), CD11c (P150, 95; CR4), and CD18 (beta-2). +3 more findings

  4. 1990-11-01

    Identification of nuclear tau isoforms in human neuroblastoma cells

    ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America

    Key finding: This work indicates that tau may function in processes not directly associated with microtubules and that highly insoluble complexes of tau may also play a role in normal cellular physiology.

  5. 1990-11-01

    A case-control study of Alzheimer's disease in Australia

    ✓ Peer-reviewed Risk factors Neurology

    Key finding: Significant odds ratios were found for 4 variables: a history of either dementia, probable AD, or Down's syndrome in a 1st-degree relative, and underactivity as a behavioral trait in both the recent and more distant past.

  6. 1990-11-01

    Slowly progressive aphasia: three cases with language, memory, CT and PET data

    ✓ Peer-reviewed Digital health tools Journal of neurology, neurosurgery, and psychiatry

    Key finding: The data suggest that the syndrome of "progressive aphasia": 1) does not involve a uniform symptom complex; 2) does not necessarily develop into a full blown dementia syndrome; 3) varies greatly in rate of progression from case to case; 4) is associated with normal brain structure (on computer tomography); and 5) is associated with abnormal left temporal lobe metabolism as measured by fluorodeoxyglucose (FDG) positron emission tomography (PET).

October 1990 1

  1. 1990-10-01

    Caregiving and the Stress Process: An Overview of Concepts and Their Measures

    ✓ Peer-reviewed Caregiving The Gerontologist

    This paper views caregiver stress as a consequence of a process comprising a number of interrelated conditions, including the socioeconomic characteristics and resources of caregivers and the primary and secondary stressors to which they are exposed.

Browse the library by subject, with the full score breakdown →