Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,851–12,875 of 27,380 studies, newest first · page 515 of 1096.
May 2019 25
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2019-05-10
Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease?
50/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: We found no disease effects on retinal vascular measures (all β's < |0.15|, all P > .2), adjusted for confounders. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-10
Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer's disease
48/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: We found brain volume reduction in the bilateral temporal, amygdala, parahippocampal and lower parietal lobe and left cingulate and precuneus regions (family-wise error, p < 0.05). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-10
Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer's disease
38/100 ✓ Peer-reviewed Drug development Behavioural brain research
Key finding: Spatial memory test showed that exenatide administration (100 μg/kg twice per day) prevented cognitive decline after 16 weeks of treatment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-09
Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study
64/100 ✓ Peer-reviewed Treatments International journal of environmental research and public health
Key finding: In conclusion, our analysis showed no positive association of sepsis with statin use in patients with dementia.
Full summary, score breakdown and related studies → Original source
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2019-05-09
Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers
41/100 ✓ Peer-reviewed Brain scans and imaging Experimental & molecular medicine
Key finding: However, research attempting to establish the reliability of Aβ and tau as biomarkers has culminated in an amalgamation of contradictory results and theories regarding the biomarker concentrations necessary for an accurate diagnosis.
Full summary, score breakdown and related studies → Original source
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2019-05-09
Your Robot Therapist Will See You Now: Ethical Implications of Embodied Artificial Intelligence in Psychiatry, Psychology, and Psychotherapy
53/100 ✓ Peer-reviewed Prevention and risk Journal of medical Internet research
Key finding: From an ethical perspective, important benefits of embodied AI applications in mental health include new modes of treatment, opportunities to engage hard-to-reach populations, better patient response, and freeing up time for physicians. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-09
Alzheimer's disease: risk factors and potentially protective measures
52/100 ✓ Peer-reviewed Prevention and risk Journal of biomedical science
Key finding: As a complement, some protective factors associated with a lower risk of disease incidence, such as cognitive reserve, physical activity and diet will also be addressed.
Full summary, score breakdown and related studies → Original source
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2019-05-08
Determinants of self- and carer-rated quality of life and caregiver burden in Alzheimer disease
43/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: There was a strong correlation between carer- and self-rated QoL, with patients consistently rating their QoL higher than caregivers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-08
Elevated cerebrospinal fluid total tau in former professional athletes with multiple concussions
46/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Concentrations of phosphorylated tau181, total tau (t-tau), and β-amyloid in the CSF were measured in 3 groups: 22 former professional athletes with multiple concussions (mean ± SD age 55.9 ± 12.2 years), 5 healthy controls (age 57.4 ± 5.2 years), and 12 participants (age 60.0 ± 6.6 years) diagnosed with Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-08
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
53/100 ✓ Peer-reviewed Risk genes beyond APOE Molecular neurodegeneration
Key finding: Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-08
Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal
48/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: In MCI reverters, abnormal biomarkers for AD pathology are associated with subsequent decline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-07
Blindness and Visual Impairment in the Medicare Population: Disparities and Association with Hip Fracture and Neuropsychiatric Outcomes
49/100 ✓ Peer-reviewed Digital health tools Ophthalmic epidemiology
Key finding: The prevalence of low vision in the Medicare population was 994/100,000 and increased significantly with age, Black (1,854/100,000) or Hispanic (2,862/100,000) race/ethnicity, female gender (1,181/100,000), and Medicaid eligibility (2,975/100,000). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-07
Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection
57/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: Recently, we showed that inducing gamma oscillations with visual stimulation (gamma entrainment using sensory stimuli, or GENUS) reduced amyloid plaques and phosphorylated tau in multiple mouse models. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-07
Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses
48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Frontiers in neuroscience
Key finding: We place these findings in the context of the selective, but by no means unique, involvement of BFCNs and their trophic dependence on NGF signaling and speculate as to how pathogenesis in these neurons is initiated, amplified and ultimately results in their dysfunction and death. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-07
A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia
55/100 ✓ Peer-reviewed Digital health tools Brain and language
Key finding: All patient groups declined significantly on measures of both speech fluency and grammar, although patients with nonfluent/agrammatic PPA (naPPA) declined to a greater extent than patients with the semantic variant, the logopenic variant, and bvFTD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-07
Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway
64/100 ✓ Peer-reviewed How common it is mBio
Key finding: Alzheimer's disease (AD), the most common cause of dementia, has long been associated with bacterial infections and inflammation-causing immunosenescence. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-06
Palliative care for people with dementia living at home: A systematic review of interventions
69/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: The review highlights the paucity of high-quality dementia-specific research in this area and recommends key areas for future work, for example, the need for process evaluation to identify facilitators and barriers to implementing interventions.
Full summary, score breakdown and related studies → Original source
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2019-05-04
Transcriptomic analysis of probable asymptomatic and symptomatic alzheimer brains
45/100 ✓ Peer-reviewed Brain scans and imaging Brain, behavior, and immunity
Key finding: Differential expression analysis identified a significant increase of transcriptomic activity in the frontal cortex of AsymAD subjects, suggesting fundamental changes in AD may initially begin within the frontal cortex region prior to AD diagnosis.
Full summary, score breakdown and related studies → Original source
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2019-05-04
Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort
62/100 ✓ Peer-reviewed Getting a diagnosis Brain, behavior, and immunity
Key finding: Recently, several animal studies indicated that the 'gut-brain' axis might contribute to the amyloid deposition of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-03
Advances in cerebral amyloid angiopathy imaging
39/100 ✓ Peer-reviewed Vascular contributions Therapeutic advances in neurological disorders
Key finding: The vascular injuries of CAA result in both hemorrhagic and ischemic manifestations and related structural changes on MRI, including cerebral microbleeds, cortical superficial siderosis, white matter hyperintensity, MRI-visible perivascular spaces, and cortical microinfarcts.
Full summary, score breakdown and related studies → Original source
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2019-05-03
Comparative Effectiveness of Behavioral Interventions on Quality of Life for Older Adults With Mild Cognitive Impairment: A Randomized Clinical Trial
84/100 ✓ Peer-reviewed Cognitive tests and assessment JAMA network open
Key finding: These results provide further support for behavioral interventions for persons with MCI. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-03
Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment
68/100 ✓ Peer-reviewed Brain scans and imaging JAMA network open
Key finding: In this study, lower AD signature region volumes, brain microhemorrhages, higher WMH volumes, and infarcts were risk factors associated with dementia in older community-based residents. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-02
Galantamine plasma concentration and cognitive response in Alzheimer's disease
63/100 ✓ Peer-reviewed Treatments PeerJ
Key finding: The total sample consisted of 33 clinically diagnosed AD patients taking galantamine 8 mg/d for 6 months. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-01
Targeting Apolipoprotein E for Alzheimer's Disease: An Industry Perspective
39/100 ✓ Peer-reviewed Genetics International journal of molecular sciences
Key finding: Carriers of an ε4 allele have an increased risk of developing AD, while those with an ε2 allele are protected. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-01
Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Direct measurements of lysosomal pH uncovered a significant elevation (0.6 units) as a basis for slowed LC3 turnover and the inactivation of cathepsin D and other lysosomal hydrolases known to be unstable or less active when lysosomal pH is persistently elevated. +1 more finding
Full summary, score breakdown and related studies → Original source
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